{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:15:16Z","timestamp":1786554916937,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Fonds NutsOhra","award":["0802-099"],"award-info":[{"award-number":["0802-099"]}]},{"name":"University Medical Centre Groningen Doelmatigheidsonderzoek","award":["689 302"],"award-info":[{"award-number":["689 302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder in children. However, in primary care, it is still unknown whether there are differences in the prognosis of children with IBS compared to other diagnostic subgroups. Therefore, our aim was to describe the course of symptoms and health-related quality of life (HRQoL) for children with chronic gastrointestinal symptoms who either do or do not fulfil the Rome criteria for IBS in primary care. Second, we compared the diagnosis of the general practitioner (GP) with the Rome criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective cohort study with 1-year follow-up, including children aged 4\u201318 years with chronic diarrhoea and\/or chronic abdominal pain in primary care. During follow-up, the Rome III questionnaire, Child Health Questionnaire, and symptom questionnaires were completed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 60\/104 children (57.7%) fulfilled the Rome criteria for IBS at baseline. Compared to children without IBS, children with IBS were more commonly referred to secondary care, used more laxatives, and more often developed chronic diarrhoea and low physical HRQoL during 1 year. The diagnosis \u201cIBS\u201d from the GP matched the Rome criteria for only 10% of children, as most were diagnosed with \u201cConstipation.\u201d<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There seems to be a difference in the treatment and prognosis of symptoms and HRQoL between children with and without IBS in primary care. This suggests that it is relevant to differentiate between these groups. The evaluation and use of feasible criteria to define IBS in different healthcare settings remains subject for further studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/fampra\/cmad070","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T07:16:26Z","timestamp":1688195786000},"page":"292-298","source":"Crossref","is-referenced-by-count":3,"title":["Irritable bowel syndrome in children with chronic gastrointestinal symptoms in primary care"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-4493","authenticated-orcid":false,"given":"Esmee M","family":"Hogervorst","sequence":"first","affiliation":[{"name":"Department of General Practice, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-7827","authenticated-orcid":false,"given":"Ilse N","family":"Ganzevoort","sequence":"additional","affiliation":[{"name":"Department of General Practice, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-3666","authenticated-orcid":false,"given":"Marjolein Y","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of General Practice, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-767X","authenticated-orcid":false,"given":"Gea A","family":"Holtman","sequence":"additional","affiliation":[{"name":"Department of General Practice, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"issue":"4","key":"2024061213164527900_CIT0001","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1370\/afm.1268","article-title":"Childhood nonspecific abdominal pain in family practice: incidence, associated factors, and management","volume":"9","author":"Gieteling","year":"2011","journal-title":"Ann Fam Med"},{"issue":"3","key":"2024061213164527900_CIT0002","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1370\/afm.1490","article-title":"Prognosis of abdominal pain in children in primary care\u2014a prospective cohort study","volume":"11","author":"Lisman-van Leeuwen","year":"2013","journal-title":"Ann Fam Med"},{"issue":"4","key":"2024061213164527900_CIT0003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/02813432.2013.844405","article-title":"Prevalence, characteristics, and management of childhood functional abdominal pain in general practice","volume":"31","author":"Spee","year":"2013","journal-title":"Scand J Prim Health Care"},{"issue":"1","key":"2024061213164527900_CIT0004","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jpeds.2014.08.022","article-title":"Health-related quality of life in pediatric patients with functional and organic gastrointestinal diseases","volume":"166","author":"Varni","year":"2015","journal-title":"J Pediatr"},{"issue":"1","key":"2024061213164527900_CIT0005","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1542\/peds.2005-0114","article-title":"Quality of life for children with functional abdominal pain: a comparison study of patients\u2019 and parents\u2019 perceptions","volume":"117","author":"Youssef","year":"2006","journal-title":"Pediatrics"},{"issue":"6","key":"2024061213164527900_CIT0006","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00004703-200612000-00001","article-title":"Health-related quality of life in pediatric patients with irritable bowel syndrome: a comparative analysis","volume":"27","author":"Varni","year":"2006","journal-title":"J Dev Behav Pediatr"},{"issue":"5","key":"2024061213164527900_CIT0007","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"130","author":"Rasquin","year":"2006","journal-title":"Gastroenterology"},{"issue":"5","key":"2024061213164527900_CIT0008","doi-asserted-by":"crossref","first-page":"e0126982","DOI":"10.1371\/journal.pone.0126982","article-title":"Epidemiology of pediatric functional abdominal pain disorders: a meta-analysis","volume":"10","author":"Korterink","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"2024061213164527900_CIT0009","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/MPG.0000000000000795","article-title":"Symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared with healthy controls","volume":"61","author":"Varni","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"2024061213164527900_CIT0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/1471-2296-14-179","article-title":"Challenges in diagnostic accuracy studies in primary care: the fecal calprotectin example","volume":"14","author":"Holtman","year":"2013","journal-title":"BMC Fam Pract"},{"key":"2024061213164527900_CIT0011","volume-title":"The CHQ Scoring and Interpretation Manual","author":"HealthActCHQ","year":"2008"},{"issue":"3","key":"2024061213164527900_CIT0012","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.mpg.0000172748.64103.33","article-title":"Development and preliminary validation of the questionnaire on pediatric gastrointestinal symptoms to assess functional gastrointestinal disorders in children and adolescents","volume":"41","author":"Caplan","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"2024061213164527900_CIT0013","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5152\/tjg.2016.15148","article-title":"Validity and reliability study of the pediatric Rome III questionnaire for Turkish children and adolescents","volume":"27","author":"\u00d6zgen\u00e7","year":"2016","journal-title":"Turk J Gastroenterol"},{"issue":"1","key":"2024061213164527900_CIT0014","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/fampra\/cmw111","article-title":"Dientamoeba fragilis colonization is not associated with gastrointestinal symptoms in children at primary care level","volume":"34","author":"Holtman","year":"2017","journal-title":"Fam Pract"},{"issue":"2","key":"2024061213164527900_CIT0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1207\/S15326888CHC3102_1","article-title":"Children with recurrent abdominal pain: comparison of community and tertiary care samples","volume":"31","author":"Robins","year":"2002","journal-title":"Children s Health Care"},{"issue":"2","key":"2024061213164527900_CIT0016","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1370\/afm.1736","article-title":"Predictors of chronic abdominal pain affecting the well-being of children in primary care","volume":"13","author":"Spee","year":"2015","journal-title":"Ann Fam Med"},{"issue":"1","key":"2024061213164527900_CIT0017","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajg.2020.02.002","article-title":"Emotional dysregulation in adolescents with functional gastrointestinal disorders","volume":"21","author":"G\u00fcven","year":"2020","journal-title":"Arab J Gastroenterol"},{"issue":"1","key":"2024061213164527900_CIT0018","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12876-018-0769-z","article-title":"Classification of pediatric functional gastrointestinal disorders related to abdominal pain using Rome III vs. Rome IV criterions","volume":"18","author":"Edwards","year":"2018","journal-title":"BMC Gastroenterol"},{"issue":"9","key":"2024061213164527900_CIT0019","first-page":"404","article-title":"NHG-Standaard Buikpijn bij kinderen","volume":"55","author":"Gieteling","year":"2012","journal-title":"Huisarts Wet"}],"container-title":["Family Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/fampra\/article-pdf\/41\/3\/292\/58207695\/cmad070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/fampra\/article-pdf\/41\/3\/292\/58207695\/cmad070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:29:11Z","timestamp":1718198951000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/fampra\/article\/41\/3\/292\/7216527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,7,1]]},"published-print":{"date-parts":[[2024,6,12]]}},"URL":"https:\/\/doi.org\/10.1093\/fampra\/cmad070","relation":{},"ISSN":["1460-2229"],"issn-type":[{"value":"1460-2229","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,1]]},"published":{"date-parts":[[2023,7,1]]}}}