{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:32:39Z","timestamp":1785529959352,"version":"3.56.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR300650"],"award-info":[{"award-number":["NIHR300650"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","award":["IS-BRC-1215-20007"],"award-info":[{"award-number":["IS-BRC-1215-20007"]}],"id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Effective and targeted endometrial cancer prevention strategies could reduce diagnoses by 60%. Whether this approach is acceptable to individuals and general practitioners (GPs) is currently unknown. This study sought to determine attitudes towards the provision of personalised endometrial cancer risk assessments and the acceptability of potential prevention strategies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Specific online questionnaires were developed for individuals aged 45\u201360 years with a uterus and UK-practising GPs, with social media, charity websites, and email used to advertise the study. Individuals completed the questionnaires between February and April 2022.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 660 lay questionnaire respondents, 90.3% (n\u2005=\u2005596) thought that undergoing an endometrial cancer risk assessment was a good or very good idea and 95.6% (n\u2005=\u2005631) would be willing to undergo such an assessment. The commonest reasons for wanting to participate were \u201cto try and reduce my risk\u201d (n\u2005=\u2005442, 67.0%), \u201cto be informed\u201d (n\u2005=\u2005354, 53.6%), and \u201cit could save my life\u2019 (n\u2005=\u2005315, 47.7%). Over 80% of respondents would make lifestyle changes to reduce their endometrial cancer risk (n\u2005=\u2005550), with half accepting a pill, Mirena, or hysterectomy for primary prevention. GPs were similarly engaged, with 93.0% (n\u2005=\u2005106) willing to offer an endometrial cancer risk assessment if a tool were available, potentially during a Well Woman screen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Personalised endometrial cancer risk assessments are acceptable to potentially eligible individuals and GPs and could be accommodated within routine practice. Clinical trials to determine the effectiveness of lifestyle modification and Mirena for endometrial protection are urgently required and should be targeted at those at greatest disease risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/fampra\/cmad076","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T18:40:16Z","timestamp":1690569616000},"page":"949-955","source":"Crossref","is-referenced-by-count":2,"title":["Lay and general practitioner attitudes towards endometrial cancer prevention: a cross-sectional study"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2763-7370","authenticated-orcid":false,"given":"Sarah J","family":"Kitson","sequence":"first","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urwaa","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-8630","authenticated-orcid":false,"given":"Emma J","family":"Crosbie","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester , Manchester ,","place":["UK"]},{"name":"Department of Obstetrics and Gynaecology, St Mary\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"2024121216244247500_CIT0001","author":"Cancer Research UK","year":"2022"},{"issue":"10333","key":"2024121216244247500_CIT0002","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0140-6736(22)00323-3","article-title":"Endometrial cancer","volume":"399","author":"Crosbie","year":"2022","journal-title":"Lancet"},{"issue":"9","key":"2024121216244247500_CIT0003","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/bjc.2016.304","article-title":"Cancer incidence and mortality projections in the UK until 2035","volume":"115","author":"Smittenaar","year":"2016","journal-title":"Br J Cancer"},{"key":"2024121216244247500_CIT0004","author":"Office for National Statistics","year":"2016"},{"issue":"11","key":"2024121216244247500_CIT0005","doi-asserted-by":"crossref","first-page":"e0165539","DOI":"10.1371\/journal.pone.0165539","article-title":"Long-term secondary care costs of endometrial cancer: a prospective cohort study nested within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)","volume":"11","author":"Pennington","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"2024121216244247500_CIT0006","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3945\/ajcn.114.094854","article-title":"Adherence to cancer prevention guidelines and cancer incidence, cancer mortality, and total mortality: a prospective cohort study","volume":"101","author":"Kabat","year":"2015","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"2024121216244247500_CIT0007","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/1940-6207.CAPR-22-0129","article-title":"Quantifying the effect of physical activity on endometrial cancer risk","volume":"15","author":"Kitson","year":"2022","journal-title":"Cancer Prev Res (Phila)"},{"issue":"1","key":"2024121216244247500_CIT0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/1940-6207.CAPR-16-0224","article-title":"Identifying high-risk women for endometrial cancer prevention strategies: proposal of an endometrial cancer risk prediction model","volume":"10","author":"Kitson","year":"2017","journal-title":"Cancer Prev Res (Phila)"},{"issue":"1","key":"2024121216244247500_CIT0009","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ygyno.2018.02.006","article-title":"Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. 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