{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:33:27Z","timestamp":1787945607333,"version":"build-2784847793"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 108-2813-C-038-035-B"],"award-info":[{"award-number":["MOST 108-2813-C-038-035-B"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Proton pump inhibitors (PPIs) and histamine-2 receptor (H2) antagonists change the gastric pH and reduce the intestinal absorption of nonheme iron. Case reports and case-control studies have demonstrated that absorption of iron is affected by gastric acidity, but the clinical importance of these drug-drug interactions has remained uncertain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The present case-control study employed 2 million longitudinal claims in 2011\u20132018 in the Taiwan National Health Insurance Research Database to investigate the impact of PPIs\/H2 antagonists on the occurrence of iron-deficiency anaemia (IDA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The present study retrospectively compared exposure to PPIs\/H2 antagonists for 1 year among 5,326 cases with IDA and 21,304 matched controls. The postdiagnosis prescribing pattern was also calculated to understand current practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Long-term (\u22652 month) use of PPIs\/H2 antagonists resulted in a higher risk of developing IDA than noncontinuous use\/nonuse of those drugs (adjusted odds ratio [aOR]\u2005=\u20052.36, 95% confidence interval [CI]\u2005=\u20051.94\u20132.86, P\u2005&amp;lt;\u20050.001). There were significant changes in the postdiagnosis prescribing patterns of PPIs\/H2 antagonists. The risk of developing IDA remained significant in the female subgroup (aOR\u2005=\u20052.16, 95% CI\u2005=\u20051.73\u20132.70, P\u2005&amp;lt;\u20050.001) and was even more prominent in those aged\u2005\u2265\u200550 years (aOR\u2005=\u20052.68, 95% CI\u2005=\u20051.94\u20133.70, P\u2005&amp;lt;\u20050.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study found that long-term use of PPIs\/H2 antagonists increased the risk of developing IDA, and there was strong evidence of prescription pattern adjustments postdiagnosis. Physicians and pharmacists should be aware of this risk when patients are expected to take or have been taking PPIs\/H2 antagonists for the long term.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/fampra\/cmad090","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T19:51:08Z","timestamp":1695844268000},"source":"Crossref","is-referenced-by-count":3,"title":["Is use of a long-term proton pump inhibitor or histamine-2 receptor antagonist a risk factor for iron-deficiency anaemia in Taiwan? A neglected clinical drug-drug interaction"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2642-1204","authenticated-orcid":false,"given":"Yi-Ting","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5206-8021","authenticated-orcid":false,"given":"Ya-Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-5760","authenticated-orcid":false,"given":"Chao-Yu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-6946","authenticated-orcid":false,"given":"Horng-Jiun","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-4262","authenticated-orcid":false,"given":"Li-Na","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Pharmacy, Taipei Municipal Wan-Fang Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-5834","authenticated-orcid":false,"given":"Kuei-Ju","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Pharmacy, Taipei Municipal Wan-Fang Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-7152","authenticated-orcid":false,"given":"Hsiang-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Pharmacy, Taipei Municipal Wan-Fang Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"issue":"7","key":"2025032923403701600_CIT0001","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1440-1746.2011.06750.x","article-title":"Prevalence of gastroesophageal reflux disease in a general population in Taiwan","volume":"26","author":"Hung","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"issue":"10270","key":"2025032923403701600_CIT0002","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"key":"2025032923403701600_CIT0003","author":"Department of Statistics. 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