{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:39:16Z","timestamp":1777430356447,"version":"3.51.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Society of General Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The safety of non-steroids anti-inflammatory drugs (NSAIDs) in the context of pharyngitis is doubtful with contradictory results in the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the risk of peritonsillar abscess (PTA) associated to NSAIDs consumption during a pharyngitis episode observed in primary care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>A retrospective cohort study using Observatory of General Medicine Datalink from 1995 to 2010. All patients consulting a GP from the Datalink network for pharyngitis have been included. The occurrence of a PTA in the 15 days following the consultation for pharyngitis was matched. The association between PTA and prescriptions of NSAIDs was studied via an adjusted logistic regression model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period, 105 802 cases of pharyngitis and 48 cases of PTA following a pharyngitis were reported, concerning respectively 67 765 and 47 patients. In the multivariate analysis, the risk of PTA was associated positively with a NSAIDs prescription (OR = 2.9, 95% CI = 1.6\u20135.2). Other factors associated with PTA occurrence were the prescription of corticosteroids (OR = 3.1, 95% CI = 1.3\u20137.6) and an age between 20 and 40 years (OR = 5.7, 95% CI = 2.5\u201313.0). The prescription of antibiotics was not significantly associated with PTA (P = 0.7).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prescription of NSAIDs in pharyngitis may increase the risk of PTA. This study encourages considering cautiously the balance between benefits and harms before prescription of NSAIDs for pharyngitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/fampra\/cmy111","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T11:11:16Z","timestamp":1539861076000},"page":"425-430","source":"Crossref","is-referenced-by-count":8,"title":["Non-steroids anti-inflammatory drugs and risk of peritonsillar abscess in pharyngitis: a French longitudinal study in primary care\u2020"],"prefix":"10.1093","volume":"36","author":[{"given":"Cedric","family":"Piroulas","sequence":"first","affiliation":[{"name":"D\u00e9partement de m\u00e9decine g\u00e9n\u00e9rale, UFR des sciences de la sant\u00e9 Simone Veil, Universit\u00e9 Versailles-Saint-Quentin-en-Yvelines, Montigny le Bretonneux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Devillers","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine g\u00e9n\u00e9rale, UFR des sciences de la sant\u00e9 Simone Veil, Universit\u00e9 Versailles-Saint-Quentin-en-Yvelines, Montigny le Bretonneux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Souty","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00e9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP UMR-S1136), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sicsic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay, INSERM, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations, Villejuif cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Boisnault","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine G\u00e9n\u00e9rale (SFMG), Issy les Moulineaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine g\u00e9n\u00e9rale, UFR des sciences de la sant\u00e9 Simone Veil, Universit\u00e9 Versailles-Saint-Quentin-en-Yvelines, Montigny le Bretonneux, France"},{"name":"Universit\u00e9 Paris Saclay, INSERM, Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations, Villejuif cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"2019080101004311100_CIT0001","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/cid\/cis847","article-title":"Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America","volume":"55","author":"Shulman","year":"2012","journal-title":"Clin Infect Dis"},{"key":"2019080101004311100_CIT0002","author":"CMIT"},{"key":"2019080101004311100_CIT0003","author":"Schappert","year":"2008"},{"key":"2019080101004311100_CIT0004","first-page":"45","article-title":"Use of antibiotics for sore throat and incidence of quinsy","volume":"57","author":"Dunn","year":"2007","journal-title":"Br J Gen Pract"},{"key":"2019080101004311100_CIT0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.aforl.2014.07.001","article-title":"Recommandation de la SFORL sur les complications locor\u00e9gionales des pharyngites","volume":"131","author":"Paganelli","year":"2014","journal-title":"Annales fran\u00e7aises d\u2019Oto-rhino-laryngologie et de Pathologie Cervico-faciale"},{"key":"2019080101004311100_CIT0006","author":"Pinaud","year":"2008"},{"key":"2019080101004311100_CIT0007","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aorl.2006.08.001","article-title":"[Peritonsillar abscesses (quincy)]","volume":"124","author":"Page","year":"2007","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"2019080101004311100_CIT0008","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10096-016-2770-1","article-title":"Is there an association between prior anti-inflammatory drug exposure and occurrence of peritonsillar abscess (PTA)? 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