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To investigate the connection between methane production and endoparasites, this study evaluated the effect of mixed infection with Haemonchus contortus and Trichostrongylus colubriformis on methanogenic and methanotrophic community in rumen microbiota of lambs using shotgun metagenomic and real-time quantitative PCR (qPCR). The rumen content was collected from six Santa In\u00eas lambs, (7 months old) before and after 42 days infection by esophageal tube. The metagenomic analysis showed that the infection affected the microbial community structure leading to decreased abundance of methanotrophs bacteria, i.e. \u03b1-proteobacteria and \u03b2-proteobacteria, anaerobic methanotrophic archaea (ANME), protozoa, sulfate-reducing bacteria, syntrophic bacteria with methanogens, geobacter, and genes related to pyruvate, fatty acid, nitrogen, and sulfur metabolisms, ribulose monophosphate cycle, and Entner\u2013Doudoroff Pathway. Additionally, the abundance of methanogenic archaea and the mcrA gene did not change. The co-occurrence networks enabled us to identify the interactions between each taxon in microbial communities and to determine the reshaping of rumen microbiome associations by gastrointestinal nematode infection. Besides, the correlation between ANMEs was lower in the animal\u2019s postinfection. Our findings suggest that gastrointestinal parasites potentially lead to decreased methanotrophic metabolism-related microorganisms and genes.<\/jats:p>","DOI":"10.1093\/femsec\/fiae083","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T15:00:29Z","timestamp":1717081229000},"source":"Crossref","is-referenced-by-count":4,"title":["Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs"],"prefix":"10.1093","volume":"100","author":[{"given":"Patricia Spoto","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Laboratory of Animal Nutrition, Center for Nuclear Energy in Agriculture, University of Sa\u0303o Paulo , 303 Centenario Avenue, Piracicaba, SP 13416-000 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo Antonio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Nutrition, Center for Nuclear Energy in 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