{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:17:30Z","timestamp":1789139850834,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Government's Investissement d'Avenir program, Laboratoire d'Excellence \u201cIntegrative Biology of Emerging Infectious Diseases\u201d","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]},{"name":"Programa Nacional de Becas de Postgrado en el Exterior \u201cDon Carlos Antonio L\u00f3pez\u201d","award":["205\/2018"],"award-info":[{"award-number":["205\/2018"]}]},{"DOI":"10.13039\/100024180","name":"Collectivit\u00e9 de Corse","doi-asserted-by":"publisher","award":["0300"],"award-info":[{"award-number":["0300"]}],"id":[{"id":"10.13039\/100024180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tick microbiota influences Borrelia colonization, but changes in the microbiota-derived metabolite and how this affects tick physiology and vector competence is unclear. We investigated whether microbiota-induced metabolite modifications influence tick physiology and pathogen transmission. Using an antimicrobiota vaccine (live Escherichia coli) to immunize mice, we generated host antibodies that modulated the tick microbiome, decreasing bacterial abundance and increasing lysine levels in ticks. Elevated lysine correlated with increased tick weight. Lysine supplementation experiments enhanced defensin expression with DefMT6 exhibiting anti-Borrelia activity, reducing pathogen load in ticks. Our findings demonstrate that antimicrobiota vaccines induce metabolite changes, affecting tick physiology, immunity, and vector competence. These insights open new avenues for developing microbiota-targeted strategies to control tick-borne diseases<\/jats:p>","DOI":"10.1093\/femsec\/fiaf082","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:51:31Z","timestamp":1755085891000},"source":"Crossref","is-referenced-by-count":5,"title":["Antimicrobiota vaccine induces lysine-mediated modulation of tick immunity affecting <i>Borrelia<\/i> colonization"],"prefix":"10.1093","volume":"101","author":[{"given":"Lourdes","family":"Mateos-Hernandez","sequence":"first","affiliation":[{"name":"ANSES, INRAE, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, UMR BIPAR, Laboratoire de Sant\u00e9 Animale , Maisons-Alfort F-94700 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianet","family":"Abuin-Denis","sequence":"additional","affiliation":[{"name":"ANSES, INRAE, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, UMR BIPAR, Laboratoire de Sant\u00e9 Animale , 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