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There is however a paucity of data regarding the ability of gut bacteria, in particular those belonging to the Bacillota (previously Firmicutes) phylum, to depolymerise and ferment \u03b2-mannans. In this study, we tested a total of 12 strains, including nine Bacillota, for their ability to metabolise and cross-feed on \u03b2-mannans. Three of the six butyrate-producing Bacillota strains, namely Roseburia intestinalis L1-82, Roseburia faecis M72\/1, and Coprococcus eutactus ART55\/1, were able to metabolise carob galactomannan, konjac glucomannan, and softwood spruce acetylated galactoglucomannan, which corresponded with their carbohydrate active enzyme profiles, whilst Faecalibacterium prausnitzii S3L\/3 only grew well on \u03b2-mannan endo-mannanase digests. To investigate competition and microbial cross-feeding on \u03b2-mannans, growth assays were conducted with co-cultures of up to six strains belonging to both the Bacillota phylum and a Bacteroidetes \u03b2-mannan utilising strain, Bacteroides ovatus V975. All strains in the mixes were able to co-exist, including the non-mannan degrading butyrate producers, with butyrate being formed as one of the major fermentation products. These studies suggest that \u03b2-mannans may offer a notable prebiotic approach to promoting butyrate-producing bacteria and gut health.<\/jats:p>","DOI":"10.1093\/femsec\/fiag063","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:56:50Z","timestamp":1781276210000},"source":"Crossref","is-referenced-by-count":1,"title":["Metabolism of\n                    <i>\u03b2<\/i>\n                    -mannans by representative, understudied Bacillota species from the human colon"],"prefix":"10.1093","volume":"102","author":[{"given":"Galiana","family":"Lo","sequence":"first","affiliation":[{"name":"Gut Health Group, Rowett Institute, University of Aberdeen , Foresterhill, Aberdeen, Scotland AB25 2ZD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3527-8101","authenticated-orcid":false,"given":"Sabina Leanti","family":"La\u00a0Rosa","sequence":"additional","affiliation":[{"name":"Faculty of Biosciences, Norwegian University of Life Sciences , 1432 Aas ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rge","family":"Westereng","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences , 1432 Aas ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-4059","authenticated-orcid":false,"given":"Phillip B","family":"Pope","sequence":"additional","affiliation":[{"name":"Faculty of Biosciences, Norwegian University of Life Sciences , 1432 Aas ,","place":["Norway"]},{"name":"Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences , 1432 Aas ,","place":["Norway"]},{"name":"Centre for Microbiome Research, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Translational Research Institute , Woolloongabba, 4102 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Louis","sequence":"additional","affiliation":[{"name":"Gut Health Group, Rowett Institute, University of Aberdeen , Foresterhill, Aberdeen, Scotland AB25 2ZD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-895X","authenticated-orcid":false,"given":"Carlos","family":"Sabater","sequence":"additional","affiliation":[{"name":"Gut Health Group, Rowett Institute, University of Aberdeen , Foresterhill, Aberdeen, Scotland AB25 2ZD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-0978","authenticated-orcid":false,"given":"Sylvia H","family":"Duncan","sequence":"additional","affiliation":[{"name":"Gut Health Group, Rowett Institute, University of 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