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This is the first study to explore the halotolerant soil microbiome of this region with culture-dependent methods. Forty-nine taxonomically diverse bacterial isolates were obtained from dry soil biocrust, surface soil, and permafrost soil. Nine isolates were selected for whole genome sequencing; these genomes showed adaptations to their cold, saline native environment, such as cold shock proteins and a large number of osmoprotectant transporters. The genomes also contained several biosynthetic gene clusters, including a large variety of clusters putatively involved in the production of antimicrobial compounds. Furthermore, most of the sequenced genomes showed low digital DNA\u2013DNA hybridization to their closest relatives, suggesting that they represent novel species. Overall, this study demonstrates the unexplored potential of High Arctic deserts as a source of novel halotolerant bacteria and their secondary metabolites.<\/jats:p>","DOI":"10.1093\/femsec\/fiag073","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:49:13Z","timestamp":1784116153000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomic adaptations of novel halotolerant bacteria from extreme North Greenland"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4841-4136","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Salinas-Garc\u00eda","sequence":"first","affiliation":[{"name":"Centre for Exolife Sciences (CELS), Niels Bohr Institute, University of Copenhagen , Jagtvej 155A, DK-2200 Copenhagen ,","place":["Denmark"]},{"name":"University of Copenhagen Center for Volatile Interactions (VOLT), Department of Biology, , Universitetsparken 15, DK-2100 Copenhagen 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