{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:44:36Z","timestamp":1788201876907,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Mahidol-Liverpool Chamlong Harinasuta"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>This study investigated the genetic basis of multidrug resistance in two strains of Achromobacter xylosoxidans isolated from patients attending a hospital in Thailand in 2012. These isolates were highly resistant to cephalosporins, aminoglycosides, fluoroquinolones, co-trimoxazole and carbapenems. Whole genome sequencing revealed that the two isolates were not clonally related and identified a carbapenem resistance gene-habouring integron (In687), residing in a novel genomic island, AcGI1. This In687 shares 100% identical nucleotide sequence with ones found in Acinetobacter baumannii Aci 16, isolated from the same hospital in 2007. We report the first analysis of multidrug-resistant A. xylosoxidans isolated in Thailand, and the first example of this island in A. xylosoxidans. Our data support the idea that resistance has spread in Thailand via horizontal gene transfer between species and suggest the possibility of A. xylosoxidans may serve as a reservoir of antibiotic resistance, especially in hospital setting.<\/jats:p>","DOI":"10.1093\/femsle\/fnaa109","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T03:29:24Z","timestamp":1593142164000},"source":"Crossref","is-referenced-by-count":8,"title":["AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant <i>Achromobacter xylosoxidans<\/i> in a teaching hospital in Thailand"],"prefix":"10.1093","volume":"367","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8757-3554","authenticated-orcid":false,"given":"Pisut","family":"Pongchaikul","sequence":"first","affiliation":[{"name":"Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakan 10540, Thailand"},{"name":"Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pitak","family":"Santanirand","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Antonyuk","sequence":"additional","affiliation":[{"name":"Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-8053","authenticated-orcid":false,"given":"Craig","family":"Winstanley","sequence":"additional","affiliation":[{"name":"Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair 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