{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:03:02Z","timestamp":1778605382078,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472012"],"award-info":[{"award-number":["81472012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Elizabethkingia are found to cause severe neonatal meningitis, nosocomial pneumonia, endocarditis and bacteremia. However, there are few studies on Elizabethkingia genus by comparative genomic analysis. In this study, three species of Elizabethkingia were found: E. meningoseptica, E. anophelis and E. miricola. Resistance genes and associated proteins of seven classes of antibiotics including beta-lactams, aminoglycosides, macrolides, tetracyclines, quinolones, sulfonamides and glycopeptides, as well as multidrug resistance efflux pumps were identified from 20 clinical isolates of Elizabethkingia by whole-genome sequence. Genotype and phenotype displayed a good consistency in beta-lactams, aminoglycosides and glycopeptides, while contradictions exhibited in tetracyclines, quinolones and sulfonamides. Virulence factors and associated genes such as hsp60 (htpB), exopolysaccharide (EPS) (galE\/pgi), Mg2+ transport (mgtB\/mgtE) and catalase (katA\/katG) existed in all clinical and reference strains. The functional analysis of the clusters of orthologous groups indicated that \u2018metabolism\u2019 occupied the largest part in core genome, \u2018information storage and processing\u2019 was the largest group in both accessory genome and unique genome. Abundant mobile elements were identified in E. meningoseptica and E. anophelis. The most significant finding in our study was that a single clone of E. anophelis had been circulating within diversities of departments in a clinical setting for nearly 18 months.<\/jats:p>","DOI":"10.1093\/femsle\/fnab018","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T12:13:35Z","timestamp":1614946415000},"source":"Crossref","is-referenced-by-count":11,"title":["Comparison of three species of <i>Elizabethkingia<\/i> genus by whole-genome sequence analysis"],"prefix":"10.1093","volume":"368","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-0795","authenticated-orcid":false,"given":"Chen","family":"Yang","sequence":"first","affiliation":[{"name":"Center of Laboratory Medicine, the First Medical Center of Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine, the First Medical Center of Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Infectious Diseases, Hainan Hospital, PLA General Hospital, 80 Jiang Lin Road, Sanya, Hainan Province 572016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Ye","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine, the First Medical Center of Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine, the First Medical Center of Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, 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