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This compound is synthesized as the condensation of a p-substituted benzoic acid and a polyisoprenic moiety catalyzed by the enzyme 4-hydroxybenzoate polyprenyltransferase (EC 2.5.1.39). In Plasmodium spp., this enzyme is still uncharacterized. In this work, we expressed the sequence of the Plasmodium falciparum PF3D7_0607500 gene (abbreviated as PfCOQ2) in a coq2\u0394 mutant strain of Saccharomyces cerevisiae, and studied the functionality of its gene product. This open reading frame could complement S. cerevisiae coq2\u0394 mutant growth defect on media with glycerol as a carbon source. Further, UQ was unequivocally identified in lipid extracts from this coq2\u0394 mutant when expressing PfCOQ2. Remarkably, UQ was detected under those conditions when S. cerevisiae cells were metabolically labeled with either [ring-14C(U)]-p-aminobenzoic acid or [ring-14C(U)]-4-hydroxybenzoic acid. However, no UQ was detected in P. falciparum if labeled with p-aminobenzoic acid. These results indicate that PfCOQ2 is a 4-hydroxybenzoate polyprenyltransferase. Further, its substrate profile seems not dissimilar to that of S. cerevisiae, but, as in other organisms, p-aminobenzoic acid does not act as an aromatic precursor in UQ biosynthesis in P. falciparum. The reason for this last feature remains to be established, but may lie upstream of PfCOQ2.<\/jats:p>","DOI":"10.1093\/femsle\/fnad050","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T23:49:21Z","timestamp":1686268161000},"source":"Crossref","is-referenced-by-count":4,"title":["<i>Plasmodium falciparum COQ2<\/i>\n                    gene encodes a functional 4-hydroxybenzoate polyprenyltransferase"],"prefix":"10.1093","volume":"370","author":[{"given":"Camila Andrea","family":"Zafra","sequence":"first","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Avenida Professor Lineu Prestes, 1374, Butant\u00e3, 05008-000, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcell","family":"Crispim","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Avenida Professor Lineu Prestes, 1374, Butant\u00e3, 05008-000, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignasi Bofill","family":"Verdaguer","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Avenida Professor Lineu Prestes, 1374, Butant\u00e3, 05008-000, S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro Garc\u00eda","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Environmental Bioinorganic Chemistry and Metallodrugs, Institute of Chemistry at the University of S\u00e3o Paulo , Avenida Professor Lineu Prestes, 748, Butant\u00e3, 05008-000, S\u00e3o Paulo ,","place":["Brazil"]},{"name":"Chemistry Program, University of Quind\u00edo , Carrera 15 #12N, Armenia, Quind\u00edo 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