{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:25Z","timestamp":1753876165202,"version":"3.41.2"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bacterial vaginitis (BV) is a syndrome of increased vaginal discharge, fishy smelling leucorrhea, and itching and burning vulva caused by the microecological imbalance in the vagina induced by mixture of Gardnerella vaginalis (GV) and some anaerobic bacteria. Fenticonazole, an imidazole derivative and antimicrobial compound, has been demonstrated to exert effective therapeutic effects in mixed vaginitis. Accordingly, our study was designed to explore the potential role of fenticonazole in GV-infected BV mouse models. Female C57\/BL6 mice were injected intraperitoneally with \u03b2-estradiol 3 days before and on the day of GV infection to maintain a pseudoestrus state. On the day of infection, mice were intravaginally inoculated with 20\u00a0\u00b5l of a suspension of GV (6\u00a0\u00d7\u00a0106 CFU\/ml). Fenticonazole was administered as 2% vaginal cream (0.2\u00a0mg each mouse) by intravaginal application once a day for 3 days beginning the day of infection. At day 3 postinfection, the mice were sacrificed and vaginal washes were harvested. GV proliferation and Lactobacillus content were calculated in the vaginal lavage. Neutrophil counts in the vaginal lavage were observed through Pap staining. Myeloperoxidase (MPO) activity and proinflammatory cytokine (TNF-\u03b1, IL-1\u03b2, IL-6, iNOS, COX2, and NF-\u03baB) levels in vaginal tissues were measured by ELISA and western blotting. Vaginal tissues were stained by hematoxylin and eosin (H&amp;E) to examine the exfoliation of vaginal epithelial cells. GV infection increased GV proliferation and neutrophil counts but reduced Lactobacillus content in the vaginal lavage, as well as enhanced MPO activity, proinflammatory cytokine levels, and the exfoliation of vaginal epithelial cells in vaginal tissues of BV mouse models. However, administration of fenticonazole significantly ameliorated the above phenomena. Fenticonazole greatly improves the symptoms of GV-induced BV in mouse models.<\/jats:p>","DOI":"10.1093\/femsle\/fnad119","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:47:18Z","timestamp":1699948038000},"source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic effects of fenticonazole on bacterial vaginosis in mice"],"prefix":"10.1093","volume":"370","author":[{"given":"Jinfen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Shiyan Maternal and Child Health Hospital , No. 256, Linyin Avenue, Maojian District, Shiyan 442000, Hubei Province , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiran","family":"Peng","sequence":"additional","affiliation":[{"name":"Clinical Medicine Department of Xinjiang Medical University , No. 152 Longquan Street, Tianshan District, Urumqi 830000, Xinjiang Uygur Autonomous Region , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shiyan Maternal and Child Health Hospital , No. 256, Linyin Avenue, Maojian District, Shiyan 442000, Hubei Province , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shiyan Maternal and Child Health Hospital , No. 256, Linyin Avenue, Maojian District, Shiyan 442000, Hubei Province , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shiyan Maternal and Child Health Hospital , No. 256, Linyin Avenue, Maojian District, Shiyan 442000, Hubei Province , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5322-8124","authenticated-orcid":false,"given":"Ru","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Prenatal Screening, Shiyan Maternal and Child Health Hospital , Shiyan 442000, Hubei province , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"2023120518120166600_bib2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/infdis\/jiu131","article-title":"Gardnerella vaginalis outcompetes 29 other bacterial species isolated from patients with bacterial vaginosis, using in an in vitro biofilm formation model","volume":"210","author":"Alves","year":"2014","journal-title":"J Infect Dis"},{"key":"2023120518120166600_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0002-9343(83)91112-9","article-title":"Nonspecific vaginitis. 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