{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:58:07Z","timestamp":1753876687921,"version":"3.41.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to analyze ESBL-producing Escherichia coli prevalence in urine samples collected between 2011\u20132019 in Curitiba, a large city in Brazil, and relating it to antibiotic consumption and sanitary conditions. This is a longitudinal study correlating prevalence of ESBL-producing E. coli isolates from urine samples with district-level antibiotic consumption and sociodemographic data during 2011\u20132019. E. coli isolates were tested for antibiotic susceptibility and ESBL by an automated method. Statistical analysis applied linear regressions, pooled ordinary least squares, and fixed effects models for districts or years. The Chow and Hausman tests indicated that the fixed effects model for individual districts fitted best. Chi-square test was used for qualitative variables (statistical significance was set when P\u00a0&amp;lt;\u00a00.05). Among the 886\u00a0535 urine sample cultures, 9.9% of isolates were ESBL-producing E. coli. Their prevalence increased from 4.7% in 2012 to 19.3% in 2019 (P\u00a0&amp;lt;\u00a00.0001; R2\u00a0=\u00a00.922). This progressive increase correlated with age (P\u00a0=\u00a00.007; R2\u00a0=\u00a00.8725) and male gender (P\u00a0&amp;lt;\u00a00.001) and increased antibiotic consumption (P\u00a0=\u00a00.0386; R2\u00a0=\u00a00.47). The fixed effects model showed that district influences ESBL prevalence and that antibiotic consumption explains 20%\u201330% of this variation, with an increase of one defined daily dose accounting for an increase of 0.02084 percentage points of ESBL. The increasing prevalence of ESBL-producing E. coli can, to a considerable extent, be explained by increasing antibiotic consumption.<\/jats:p>","DOI":"10.1093\/femsle\/fnae038","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T02:23:42Z","timestamp":1717208622000},"source":"Crossref","is-referenced-by-count":0,"title":["Increasing community prevalence of extended-spectrum beta-lactamase-producing <i>Escherichia coli<\/i> in urine is associated with increasing district-level antibiotic consumption"],"prefix":"10.1093","volume":"371","author":[{"given":"Larissa Hermann de Souza","family":"Nunes","sequence":"first","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 , Curitiba, Paran\u00e1 80215-901 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-3598","authenticated-orcid":false,"given":"Victoria Stadler Tasca","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 , Curitiba, Paran\u00e1 80215-901 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Buttini","family":"Salviato","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Applied Social Sciences Sector, Department of Economics , Curitiba, Paran\u00e1 \u00a0 80210-170 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"de\u00a0Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 , Curitiba, Paran\u00e1 80215-901 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Hansen","family":"Suss","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 , Curitiba, Paran\u00e1 80215-901 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Jos\u00e9","family":"Vicenzi","sequence":"additional","affiliation":[{"name":"Municipal Laboratory of Curitiba , Curitiba, Paran\u00e1 81050-290 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Akira Ferreira","family":"Hino","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1. Graduate Program in Health Sciences (PPGCS), School of Medicine, Research Group on Physical Activity and Quality of Life . Curitiba, Paran\u00e1 80215-901 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"Telles","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 , Curitiba, Paran\u00e1 80215-901 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-1786","authenticated-orcid":false,"given":"Felipe Francisco","family":"Tuon","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases (LEID), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 , Curitiba, Paran\u00e1 80215-901 , 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