{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:43:26Z","timestamp":1758357806310,"version":"3.44.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["43009053"],"award-info":[{"award-number":["43009053"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Arthrospira platensis (Spirulina) is one of the highly valuable cyanobacteria in the food and pharmaceutical industries. The intracellular and extracellular polysaccharide (PS) extracts of A. platensis have been exhibited different biological functions. Here, the antibacterial and antifungal activity of PS extract from Arthrospira platensis PCST5 was studied. Arthrospira platensis PCST5 was cultured in Zarouk medium for 25 days. Then, the polysaccharide content of biomass and excreted metabolites was extracted. The antibacterial and antifungal activity of samples was assessed. The yield of PS extraction was around 8.5% and 11.5% from biomass and excreted metabolites, respectively. The most potent antibacterial activity was for sulfuric acid-treated insoluble polysaccharide fraction, against Staphylococcus aureus (MIC\u00a0=\u00a04.25\u00a0\u00b5g ml\u22121). In addition, the highest antifungal activity was observed for crude excreted metabolites against Aspergillus niger (MIC\u00a0=\u00a015.625\u00a0\u00b5g ml\u22121) and for PS extract and sulfuric acid treated insoluble polysaccharide fraction against Candida albicans (MIC\u00a0=\u00a015.625 and 0.531\u00a0\u00b5g ml\u22121, respectively). This antimicrobial activity of polysaccharide extract against S. aureus can be valued in the development of topical products for wound healing. Further studies should be performed to determine the exact structure of active component and to evaluate other potential pharmacological activities in this regard.<\/jats:p>","DOI":"10.1093\/femsle\/fnaf082","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:39:49Z","timestamp":1757515189000},"source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial activity of partially purified polysaccharide extract of <i>Arthrospira platensis<\/i> PCST5"],"prefix":"10.1093","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-0233","authenticated-orcid":false,"given":"Tahereh","family":"Hosseinabadi","sequence":"first","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences Department of Pharmacognosy, School of Pharmacy, , Tehran 19968\u201335113 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra Zare","family":"Mehrjardy","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences Department of Pharmacognosy, School of Pharmacy, , Tehran 19968\u201335113 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Mahboubi","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences Department of Pharmaceutics, School of Pharmacy, , Tehran 19968\u201335113 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-0639","authenticated-orcid":false,"given":"Maryam","family":"Tabarzad","sequence":"additional","affiliation":[{"name":"Protein Technology Research Center, Shahid Beheshti University of Medical Sciences , Tehran 19968\u201335113 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