{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:56:35Z","timestamp":1765529795560,"version":"3.48.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antimicrobial resistance is a global health threat driven by mechanisms like biofilm formation and efflux pumps. This study evaluated the antibacterial activity, antibiotic-modulating potential, and pharmacokinetic properties of 3-methoxycinnamic acid (3MCA) using in vitro and in silico methods. Although 3MCA showed no direct antibacterial effect (MIC &amp;gt; 512\u00a0\u03bcg\/ml), it enhanced the efficacy of gentamicin against multidrug-resistant (MDR) Escherichia coli (60.3% MIC reduction) and ampicillin against MDR Staphylococcus aureus (37% reduction). ADMET analysis revealed good drug-like properties, low intestinal absorption, no interaction with P-glycoprotein, and effective blood\u2013brain barrier penetration, but potential toxicological risks such as hepatotoxicity. Molecular docking showed moderate binding affinities to target proteins through stable hydrogen bonds and aromatic interactions. These results suggest that 3MCA may act as an antibiotic resistance modulator, although further in vivo studies are necessary to confirm its safety and therapeutic potential.<\/jats:p>","DOI":"10.1093\/femsle\/fnaf134","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:57:49Z","timestamp":1764075469000},"source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial and potentiating activity of 3-methoxycinnamic acid on antibiotics: an\n                    <i>in vitro<\/i>\n                    and\n                    <i>in silico<\/i>\n                    approach"],"prefix":"10.1093","volume":"372","author":[{"given":"Jos\u00e9 Thy\u00e1lisson da Costa","family":"Silva","sequence":"first","affiliation":[{"name":"Regional University of Cariri \u2013 URCA Department of Biological Sciences, , 63105-000 Crato \u2013 CE ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Pereira","family":"da 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