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To date, RT027 isolates have not conclusively been shown in Brazil, although other clade 2 isolates have been identified. This case report discusses a 60-year-old patient, with medical history of colon adenocarcinoma, who developed a severe Clostridioides difficile infection (CDI) after chemotherapy, but showed a full recovery. The infection was caused by a C. difficile RT027 strain, demonstrating conclusively for the first time that this RT is present in Brazil. 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