{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:07:10Z","timestamp":1783933630071,"version":"3.55.0"},"reference-count":137,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Enterococcus faecium has become a prominent nosocomial pathogen, demonstrating significant multidrug resistance (MDR) and persistence in both hospital and environmental contexts. Genomic analyses indicate a highly adaptable genome characterized by a substantial accessory component enriched in antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs), including plasmids, transposons, integrative conjugative elements, and prophages. The acquisition and dissemination of resistance determinants, such as vancomycin (vanA, vanB), aminoglycoside, macrolide, tetracycline, and novel oxazolidinone resistance genes (optrA, poxtA), are predominantly facilitated by horizontal gene transfer mediated by these MGEs. Virulence factors, stress response regulators, and biofilm-associated genes augment E. faecium\u2019s survival in hospital settings and its colonization potential. Environmental reservoirs, such as wastewater, animal farms, and food products, facilitate interspecies gene exchange, underscoring the pathogen\u2019s significance within the broader One Health AMR network. This review brings together what we know about E. faecium\u2019s genome, focusing on its evolutionary adaptation, mobilome architecture, clinical and epidemiological importance, and spread in the environment. It gives us a complete picture of what we need to do to keep an eye on and control the disease in the future.<\/jats:p>","DOI":"10.1093\/femsle\/fnag077","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:28:50Z","timestamp":1783380530000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomic insights into the emergence, adaptation, and environmental dissemination of\n                    <i>Enterococcus faecium<\/i>\n                    as a multidrug-resistant pathogen: a One Health perspective"],"prefix":"10.1093","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-0575","authenticated-orcid":false,"given":"Nazek","family":"AL-GALLAS","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, University of Hafr Al Batin , PO Box 1803, Hafr Al Batin 31991 , Kingdom of","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"2026071304264438100_bib1","doi-asserted-by":"publisher","first-page":"fiac045","DOI":"10.1093\/femsec\/fiac045","article-title":"Hiding in plain sight-wildlife as a neglected reservoir and pathway for the spread of antimicrobial resistance: a narrative review","volume":"98","author":"Abbassi","year":"2022","journal-title":"FEMS Microbiol Ecol"},{"key":"2026071304264438100_bib2","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.3390\/ijms24032993","article-title":"Prevalence of class 1 integron and in vitro effect of antibiotic combinations of multidrug-resistant Enterococcus species recovered from the aquatic environment in the Eastern Cape Province, South Africa","volume":"24","author":"Adeniji","year":"2023","journal-title":"Int J Mol 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