{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:19Z","timestamp":1787836699241,"version":"build-2784847793"},"reference-count":60,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003768","name":"University of Strasbourg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE44-0024-01"],"award-info":[{"award-number":["ANR-22-CE44-0024-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012681","name":"CNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pseudomonas aeruginosa relies on the redox cofactor pyrroloquinoline quinone (PQQ) for efficient glucose and ethanol metabolism via periplasmic dehydrogenases (Gcd and ExaA). While PQQ biosynthesis is well-characterized, its uptake mechanisms remain unclear. Here, we identify PA2289 (PqqU), a TonB-dependent transporter, as the primary PQQ importer in P. aeruginosa. Growth assays with PQQ-deficient mutants (\u0394pqqABCDEH) demonstrated that PqqU is the primary uptake system for exogenous PQQ, rescuing growth on glucose and ethanol. Genomic analysis across 210 P. aeruginosa and 263 Pseudomonas strains revealed high conservation of PQQ biosynthesis and utilization genes, while PqqU showed lower prevalence (47.7%) in the genus. Transcriptional analyses using fluorescent reporters and quantitative reverse transcription PCR demonstrated that PqqU expression remains unchanged in response to PQQ, varying carbon sources, or iron availability, suggesting constitutive regulation. Comparative proteomics between wild-type and \u0394pqqABCDEH strains, cultured on glucose or ethanol, uncovered extensive proteomic shifts, underscoring P. aeruginosa\u2019s metabolic adaptability. Additionally, PQQ-dependent metabolic pathways appear to indirectly influence iron homeostasis, most likely through environmental acidification. Together, these results emphasize the critical role of PqqU in PQQ uptake and its broader significance in shaping the metabolic and environmental versatility of Pseudomonas.<\/jats:p>","DOI":"10.1093\/femsle\/fnag084","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:22:45Z","timestamp":1787754165000},"source":"Crossref","is-referenced-by-count":0,"title":["PqqU (PA2289) is the primary PQQ transporter in\n                    <i>Pseudomonas aeruginosa<\/i>\n                    and links carbon metabolism to iron homeostasis"],"prefix":"10.1093","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4734-0248","authenticated-orcid":false,"given":"Christos","family":"Paschalidis","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, UMR 7242 \u2013 Biotechnologie et Signalisation Cellulaire , Strasbourg, 67412 Illkirch 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Prot\u00e9omique Strasbourg-Esplanade, Institut de Biologie Mol\u00e9culaire et Cellulaire, UAR1589 du CNRS, Universit\u00e9 de Strasbourg , Strasbourg, 67084 Cedex ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6303-9892","authenticated-orcid":false,"given":"Emmanuel","family":"Boutant","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, UMR 7242 \u2013 Biotechnologie et Signalisation Cellulaire , Strasbourg, 67412 Illkirch ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-1679","authenticated-orcid":false,"given":"Isabelle J","family":"Schalk","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, UMR 7242 \u2013 Biotechnologie et Signalisation Cellulaire , Strasbourg, 67412 Illkirch 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