{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:09:13Z","timestamp":1790168953513,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":250,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key Biomedicine Research and Development Program of Yunnan Province","award":["202402AA310017"],"award-info":[{"award-number":["202402AA310017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72274192"],"award-info":[{"award-number":["72274192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastric dysbiosis refers to disease-associated alterations in microbial composition and between-individual variability. We postulate that\u00a0Helicobacter pylori (H. pylori or Hp) exerts a context-dependent ecological effect across the Correa cascade\u2014the histopathological progression from chronic gastritis through atrophic gastritis and intestinal metaplasia to gastric cancer\u2014by constraining microbiome variation when acting alone but amplifying disease-associated divergence as pathology advances. We reanalyzed 756 gastric 16S rRNA gene profiles using Hill-number beta diversity and the Anna Karenina principle across three complementary schemes: (1) comparison of H. pylori infection status within each disease stage (Scheme-I); (2) disease progression in the Hp-negative cohorts, from healthy controls to successive disease stages (Scheme-II); and (3) disease progression in the Hp-positive, from healthy controls to successive disease stages (Scheme-III). We find: H. pylori alone consistently reduced microbiome divergence across disease stages, indicating a homogenizing effect rather than direct induction of dysbiosis. In contrast, progression to gastric cancer was the strongest driver of divergent dysbiosis, even in the absence of the bacterium. Most importantly, the presence of H. pylori caused dysbiotic divergence to emerge in multiple precancerous disease stages. These findings identify H. pylori as a context-dependent ecosystem modifier that maintains order in isolation but amplifies disease-associated dysbiosis.<\/jats:p>","DOI":"10.1093\/femsle\/fnag101","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:39:03Z","timestamp":1788867543000},"source":"Crossref","is-referenced-by-count":0,"title":["Decoupling ecological and pathogenic roles:\n                    <i>Helicobacter pylori<\/i>\n                    as a gastric hegemon maintaining order or amplifying dysbiotic chaos"],"prefix":"10.1093","volume":"373","author":[{"given":"Zhanshan (Sam)","family":"Ma","sequence":"first","affiliation":[{"name":"Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming, Yunnan 650201 ,","place":["China"]},{"name":"Faculty of Arts and Sciences, Harvard University , Cambridge, MA 02138 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katee","family":"Li","sequence":"additional","affiliation":[{"name":"St Hugh\u2019s College, University of Oxford , Oxford OX2 6LE ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Qiao","sequence":"additional","affiliation":[{"name":"Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming, Yunnan 650201 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yunnan University Department of Radiology, , Kunming, Yunnan 650021, ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianwei","family":"Li","sequence":"additional","affiliation":[{"name":"Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of 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