{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:40:35Z","timestamp":1791841235237,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"14","funder":[{"name":"Cooperative Research Program for Agriculture Science and Technology Development","award":["PJ00897001"],"award-info":[{"award-number":["PJ00897001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1093\/femsle\/fnx129","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T23:11:17Z","timestamp":1497481877000},"source":"Crossref","is-referenced-by-count":28,"title":["Occurrence of aminoglycoside-modifying enzymes among isolates of Escherichia coli exhibiting high levels of aminoglycoside resistance isolated from Korean cattle farms"],"prefix":"10.1093","volume":"364","author":[{"given":"Kuastros Mekonnen","family":"Belaynehe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Won","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Park","family":"Hong-Tae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Sang","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"key\n\t\t\t\t20180215000759_bib1","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1128\/AAC.00572-10","article-title":"Synthesis and spectrum of the neoglycoside ACHN-490","volume":"54","author":"Aggen","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib2","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1128\/AAC.00099-14","article-title":"Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents","volume":"58","author":"Almaghrabi","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib3","first-page":"1","article-title":"Antimicrobial use in livestock and monitoring report of antimicrobial resistance in animal","author":"APQA","year":"2012"},{"key":"key\n\t\t\t\t20180215000759_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/cb3005116","article-title":"Aminoglycoside antibiotics in the 21st century","volume":"8","author":"Becker","year":"2013","journal-title":"ACS Chem Biol"},{"key":"key\n\t\t\t\t20180215000759_bib5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1089\/mdr.2013.0224","article-title":"IncI1 plasmids carrying bla CTX-M-1 or bla CMY-2 genes in Escherichia coli from healthy humans and animals in Tunisia","volume":"20","author":"Ben Sallem","year":"2014","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20180215000759_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijmm.2013.02.001","article-title":"Plasmids and the spread of resistance","volume":"303","author":"Carattoli","year":"2013","journal-title":"Int J Med Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/AAC.05116-11","article-title":"Evolution of IncA\/C blaCMY-2 carrying plasmids by acquisition of the blaNDM-1 carbapenemase gene","volume":"56","author":"Carattoli","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/fpd.2010.0641","article-title":"Apramycin and gentamicin resistances in indicator and clinical Escherichia coli isolates from farm animals in Korea","volume":"8","author":"Choi","year":"2011","journal-title":"Foodborne Pathog Dis"},{"key":"key\n\t\t\t\t20180215000759_bib9","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1128\/AEM.66.10.4555-4558.2000","article-title":"Rapid and simple determination of the Escherichia coli phylogenetic group","volume":"66","author":"Clermont","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib10","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1128\/AAC.01743-09","article-title":"Discovery of a gene conferring multiple-aminoglycoside resistance in Escherichia coli","volume":"54","author":"Davis","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib11","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1099\/00221287-147-6-1671","article-title":"Commensal Escherichia coli isolates are phylogenetically distributed among geographically distinct human populations","volume":"147","author":"Duriez","year":"2001","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180215000759_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijantimicag.2015.03.008","article-title":"Molecular identification of aminoglycoside-modifying enzymes in clinical isolates of Escherichia coli resistant to amoxicillin\/clavulanic acid isolated in Spain","volume":"46","author":"Fern\u00e1ndez-Mart\u00ednez","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180215000759_bib13","doi-asserted-by":"crossref","first-page":"17224","DOI":"10.1371\/journal.pone.0017224","article-title":"Aminoglycoside resistance rates, phenotypes, and mechanisms of Gram-negative bacteria from infected patients in Upper Egypt","volume":"6","author":"Gad","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180215000759_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1179\/1973947812Y.0000000015","article-title":"Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece","volume":"24","author":"Galani","year":"2012","journal-title":"J Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/C5MD00344J","article-title":"Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives","volume":"7","author":"Garneau-Tsodikova","year":"2016","journal-title":"MedChemComm"},{"key":"key\n\t\t\t\t20180215000759_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijfoodmicro.2010.10.024","article-title":"The occurrence of virulence traits among high-level aminoglycosides resistant Enterococcus isolates obtained from feces of humans, animals, and birds in South Korea","volume":"144","author":"Han","year":"2011","journal-title":"Int J Food Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/emmm.201202413","article-title":"Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC","volume":"5","author":"Harrison","year":"2013","journal-title":"EMBO Mol Med"},{"key":"key\n\t\t\t\t20180215000759_bib18","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1128\/AEM.02171-06","article-title":"Plasmid replicon typing of commensal and pathogenic Escherichia coli isolates","volume":"73","author":"Johnson","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib19","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1128\/AEM.00601-11","article-title":"Molecular characterization of multidrug-resistant Escherichia coli isolates from Irish cattle farms","volume":"77","author":"Karczmarczyk","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance\u2014the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180215000759_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1600-0463.2011.02856.x","article-title":"Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway","volume":"120","author":"Lindemann","year":"2012","journal-title":"APMIS"},{"key":"key\n\t\t\t\t20180215000759_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jac\/dkq408","article-title":"Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates","volume":"66","author":"Livermore","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1744-8603-9-48","article-title":"Restrictions on antimicrobial use in food animal production: an international regulatory and economic survey","volume":"9","author":"Maron","year":"2013","journal-title":"Global Health"},{"key":"key\n\t\t\t\t20180215000759_bib24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/CMR.00002-11","article-title":"Food animals and antimicrobials: impacts on human health","volume":"24","author":"Marshall","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180215000759_bib25","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1093\/clinids\/24.Supplement_1.S46","article-title":"The most frequent aminoglycoside resistance mechanisms\u2014changes with time and geographic area: a reflection of aminoglycoside usage patterns?","volume":"24","author":"Miller","year":"1997","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180215000759_bib26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1089\/mdr.2012.0125","article-title":"Characterization of aminoglycoside-modifying enzymes in Enterobacteriaceae clinical strains and characterization of the plasmids implicated in their diffusion","volume":"19","author":"Mir\u00f3","year":"2013","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20180215000759_bib27","article-title":"Monitoring of antimicrobial resistance on the food-animals and meats","author":"[NARMP] National Antimicrobial Resistance Management Program","year":"2004\u20132008"},{"key":"key\n\t\t\t\t20180215000759_bib28","volume-title":"Escherichia coli and Salmonella: Cellular and Molecular Biology","author":"Neidhardt","year":"1996"},{"key":"key\n\t\t\t\t20180215000759_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S0950268800056934","article-title":"Replicon typing characterization of plasmids encoding resistance to gentamicin and apramycin in Escherichia coli and Salmonella typhimurium isolated from human and animal sources in Belgium","volume":"111","author":"Pohl","year":"1993","journal-title":"Epidemiol Infect"},{"key":"key\n\t\t\t\t20180215000759_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fmicb.2013.00044","article-title":"Broad-host-range IncP-1 plasmids and their resistance potential","volume":"4","author":"Popowska","year":"2013","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside modifying enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist Updat"},{"key":"key\n\t\t\t\t20180215000759_bib32","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1086\/315418","article-title":"Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC","volume":"181","author":"Russo","year":"2000","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180215000759_bib33","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1128\/AEM.66.2.844-849.2000","article-title":"Selective and sensitive method for PCR amplification of Escherichia coli 16S rRNA genes in soil","volume":"66","author":"Sabat","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1128\/AEM.71.3.1394-1404.2005","article-title":"Patterns of antimicrobial resistance observed in Escherichia coli isolates obtained from domestic- and wild-animal fecal samples, human septage, and surface water","volume":"71","author":"Sayah","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib35","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/molbev\/mss210","article-title":"Inferring the evolutionary history of IncP-1 plasmids despite incongruence among backbone gene trees","volume":"30","author":"Sen","year":"2012","journal-title":"Mol Biol Evol"},{"key":"key\n\t\t\t\t20180215000759_bib36","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s12275-014-4166-1","article-title":"Antimicrobial resistance, virulence genes and PFGE-profiling of Escherichia coli isolates from South Korean cattle farms","volume":"52","author":"Shin","year":"2014","journal-title":"J Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib37","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1128\/AEM.01511-15","article-title":"Prevalence of antimicrobial resistance and transfer of tetracycline resistance genes in Escherichia coli isolated from beef cattle","volume":"81","author":"Shin","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180215000759_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijantimicag.2014.04.016","article-title":"Expansive spread of IncI1 plasmids carrying bla CMY-2 amongst Escherichia coli","volume":"44","author":"Sidjabat","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180215000759_bib39","first-page":"928","article-title":"The antimicrobial resistance containment and surveillance approach\u2014a public health tool","volume":"82","author":"Simonsen","year":"2004","journal-title":"Bull World Health Organ"},{"key":"key\n\t\t\t\t20180215000759_bib40","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/molbev\/msv280","article-title":"Emergence of antimicrobial-resistant Escherichia coli of animal origin spreading in humans","volume":"33","author":"Skurnik","year":"2016","journal-title":"Mol Biol Evol"},{"key":"key\n\t\t\t\t20180215000759_bib41","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/j.1469-0691.2010.03127.x","article-title":"High prevalence of blaCTX-M extended-spectrum \u03b2-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China","volume":"16","author":"Sun","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180215000759_bib42","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3201\/eid1805.111153","article-title":"Antimicrobial drug resistance in Escherichia coli from humans and food animals, United States, 1950\u20132002","volume":"18","author":"Tadesse","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180215000759_bib43","doi-asserted-by":"crossref","first-page":"e1000344","DOI":"10.1371\/journal.pgen.1000344","article-title":"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths","volume":"5","author":"Touchon","year":"2009","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180215000759_bib44","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CMR.16.3.430-450.2003","article-title":"Versatility of aminoglycosides and prospects for their future","volume":"16","author":"Vakulenko","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180215000759_bib45","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/jac\/dkq347","article-title":"Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants","volume":"65","author":"Villa","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.drup.2012.05.001","article-title":"Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram negative bacteria: an update","volume":"15","author":"Wachino","year":"2012","journal-title":"Drug Resist Updat"},{"key":"key\n\t\t\t\t20180215000759_bib47","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1128\/AAC.47.7.2242-2248.2003","article-title":"Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China","volume":"47","author":"Wang","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib48","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/AAC.45.10.2716-2722.2001","article-title":"Evidence for transfer of CMY-2 AmpC \u03b2-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans","volume":"45","author":"Winokur","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/jac\/8.suppl_A.71","article-title":"Epidemiological aspects of aminoglycoside resistance in France","volume":"8","author":"Witchitz","year":"1981","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180215000759_bib50","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fmicb.2015.00442","article-title":"Involvement of aph(3\u0384)-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments","volume":"6","author":"Woegerbauer","year":"2015","journal-title":"Front Microbiol"}],"container-title":["FEMS Microbiology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsle\/article-pdf\/364\/14\/fnx129\/23929514\/fnx129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:10:14Z","timestamp":1518653414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsle\/article\/doi\/10.1093\/femsle\/fnx129\/3868375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":50,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2017,6,15]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femsle\/fnx129","relation":{},"ISSN":["1574-6968"],"issn-type":[{"value":"1574-6968","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,6,15]]}}}