{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:58:53Z","timestamp":1773662333644,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"14","funder":[{"DOI":"10.13039\/501100007162","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2013B021800169"],"award-info":[{"award-number":["2013B021800169"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030313895"],"award-info":[{"award-number":["2015A030313895"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1093\/femsle\/fnx145","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T11:19:38Z","timestamp":1499858378000},"source":"Crossref","is-referenced-by-count":29,"title":["An in vitro model of azithromycin-induced persistent Chlamydia trachomatis infection"],"prefix":"10.1093","volume":"364","author":[{"given":"Yaohua","family":"Xue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhida","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"key\n\t\t\t\t20180215000835_bib1","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1073\/pnas.90.9.3998","article-title":"Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro","volume":"90","author":"Beatty","year":"1993","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180215000835_bib2","doi-asserted-by":"crossref","first-page":"15971","DOI":"10.1073\/pnas.2535394100","article-title":"Transcriptome analysis of chlamydial growth during IFN-gamma-mediated persistence and reactivation","volume":"100","author":"Belland","year":"2003","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180215000835_bib3","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1128\/AAC.00962-07","article-title":"Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2","volume":"51","author":"Binet","year":"2007","journal-title":"Antimicrob Agents Ch"},{"key":"key\n\t\t\t\t20180215000835_bib4","first-page":"103","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Centers for Disease Control and Prevention","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"key\n\t\t\t\t20180215000835_bib5","volume-title":"2015 Sexually Transmitted Diseases Surveillance. Division of STD Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Center for Disease Control and Prevention","author":"Centers for Disease Control and Prevention","year":"2016"},{"key":"key\n\t\t\t\t20180215000835_bib7","doi-asserted-by":"crossref","first-page":"e103220","DOI":"10.1371\/journal.pone.0103220","article-title":"Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF","volume":"9","author":"Dille","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180215000835_bib8","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1128\/JB.00780-13","article-title":"Characterization of the interaction between the chlamydial adhesin OmcB and the human host cell","volume":"195","author":"Fechtner","year":"2013","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180215000835_bib9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s004380050538","article-title":"Genes required for assembly and function of the protein synthetic system in Chlamydia trachomatis are expressed early in elementary to reticulate body transformation","volume":"255","author":"G\u00e9rard","year":"1997","journal-title":"Mol Gen Genet"},{"key":"key\n\t\t\t\t20180215000835_bib10","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.72.4.1843-1855.2004","article-title":"Chlamydial persistence: beyond the biphasic paradigm","volume":"72","author":"Hogan","year":"2004","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180215000835_bib11","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1128\/JB.02087-12","article-title":"Chlamydia trachomatis outer membrane complex protein B (OmcB) is processed by the protease CPAF","volume":"195","author":"Hou","year":"2013","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180215000835_bib12","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3892\/etm.2015.2595","article-title":"Differences in 23S ribosomal RNA mutations between wild-type and mutant macrolide-resistant Chlamydia trachomatis isolates","volume":"10","author":"Jiang","year":"2015","journal-title":"Exp Ther Med"},{"key":"key\n\t\t\t\t20180215000835_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fcimb.2014.00044","article-title":"Commonly prescribed \u03b2-lactam antibiotics induce C. trachomatis persistence\/stress in culture at physiologically relevant concentrations","volume":"4","author":"Kintner","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"key\n\t\t\t\t20180215000835_bib15","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/jac\/dku574","article-title":"The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis","volume":"70","author":"Kong","year":"2015","journal-title":"J Antimicrob Chemoth"},{"key":"key\n\t\t\t\t20180215000835_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/cid\/ciu220","article-title":"Azithromycin versus doxycycline for the treatment of genital chlamydia infection: a meta-analysis of randomized controlled trials","volume":"59","author":"Kong","year":"2014","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180215000835_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1258\/ijsa.2010.010302","article-title":"2010 European guideline for the management of Chlamydia trachomatis infections","volume":"21","author":"Lanjouw","year":"2010","journal-title":"Int J STD AIDS"},{"key":"key\n\t\t\t\t20180215000835_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/00007435-200209000-00001","article-title":"Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials","volume":"29","author":"Lau","year":"2002","journal-title":"Sex Transm Dis"},{"key":"key\n\t\t\t\t20180215000835_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fcimb.2014.00071","article-title":"Morphologic and molecular evaluation of Chlamydia trachomatis growth in human endocervix reveals distinct growth patterns","volume":"4","author":"Lewis","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"key\n\t\t\t\t20180215000835_bib21","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/CMR.00035-15","article-title":"Human and pathogen factors associated with Chlamydia trachomatis-related infertility in women","volume":"28","author":"Menon","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180215000835_bib22","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1128\/AAC.48.4.1347-1349.2004","article-title":"Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides","volume":"48","author":"Misyurina","year":"2004","journal-title":"Antimicrob Agents Ch"},{"key":"key\n\t\t\t\t20180215000835_bib23","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1128\/JB.180.21.5784-5787.1998","article-title":"Topological analysis of Chlamydia trachomatis L2 outer membrane protein 2","volume":"180","author":"Mygind","year":"1998","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180215000835_bib24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fcimb.2013.00100","article-title":"The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence","volume":"3","author":"Ong","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"key\n\t\t\t\t20180215000835_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/0956462414531243","article-title":"Risk for HIV following a diagnosis of syphilis, gonorrhoea or chlamydia: 328,456 women in Florida, 2000\u20132011","volume":"26","author":"Peterman","year":"2015","journal-title":"Int J STD AIDS"},{"key":"key\n\t\t\t\t20180215000835_bib26","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1128\/AAC.49.5.1787-1793.2005","article-title":"Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis","volume":"49","author":"Reveneau","year":"2005","journal-title":"Antimicrob Agents Ch"},{"key":"key\n\t\t\t\t20180215000835_bib27","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/mmi.12804","article-title":"The transcriptional repressor EUO regulates both subsets of Chlamydia late genes","volume":"94","author":"Rosario","year":"2014","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180215000835_bib28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1365-2958.2012.08077.x","article-title":"The early gene product EUO is a transcriptional repressor that selectively regulates promoters of Chlamydia late genes","volume":"84","author":"Rosario","year":"2012","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180215000835_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1128\/JB.00859-15","article-title":"Regulation of Chlamydia gene expression by tandem promoters with different temporal patterns","volume":"198","author":"Rosario","year":"2016","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180215000835_bib30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.micinf.2011.03.004","article-title":"Chlamydia persistence\u2013a tool to dissect Chlamydia-host interations","volume":"13","author":"Schoborg","year":"2011","journal-title":"Microbes Infec"},{"key":"key\n\t\t\t\t20180215000835_bib31","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1128\/AAC.02211-12","article-title":"Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia","volume":"57","author":"Shima","year":"2013","journal-title":"Antimicrob Agents Ch"},{"key":"key\n\t\t\t\t20180215000835_bib32","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1128\/AAC.49.3.1120-1126.2005","article-title":"Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil","volume":"49","author":"Suchland","year":"2005","journal-title":"Antimicrob Agents Ch"},{"key":"key\n\t\t\t\t20180215000835_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fmicb.2011.00020","article-title":"An optimal method of iron starvation of the obligate intracellular pathogen, Chlamydia trachomatis","volume":"2","author":"Thompson","year":"2011","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20180215000835_bib34","volume-title":"Global Incidence and Prevalence of Selected Curable Sexually Transmitted Infections-2008","author":"World Health Organization","year":"2012"},{"key":"key\n\t\t\t\t20180215000835_bib35","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1086\/652394","article-title":"Chlamydia trachomatis persistence in vitro: an overview","volume":"201","author":"Wyrick","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180215000835_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/OLQ.0000000000000241","article-title":"Association of the in vitro susceptibility of clinical isolates of Chlamydia trachomatis with serovar and duration of antibiotic exposure","volume":"42","author":"Zheng","year":"2015","journal-title":"Sex Transm Dis"}],"container-title":["FEMS Microbiology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsle\/article-pdf\/364\/14\/fnx145\/23929857\/fnx145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T03:17:28Z","timestamp":1602472648000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsle\/article\/doi\/10.1093\/femsle\/fnx145\/3958793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":33,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2017,7,13]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femsle\/fnx145","relation":{},"ISSN":["1574-6968"],"issn-type":[{"value":"1574-6968","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,7]]}}}