{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:50:57Z","timestamp":1769925057257,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"name":"KAKENHI","award":["26450127"],"award-info":[{"award-number":["26450127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1093\/femsle\/fnx255","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T12:10:01Z","timestamp":1512994201000},"source":"Crossref","is-referenced-by-count":17,"title":["Overexpression of PDR16 confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in yeast Saccharomyces cerevisiae"],"prefix":"10.1093","volume":"365","author":[{"given":"Yuka","family":"Katsuki","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819\u20133905, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819\u20133905, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819\u20133905, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"key\n\t\t\t\t20180317043245_bib1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.plipres.2006.03.004","article-title":"Functions and metabolism of sphingolipids in Saccharomyces cerevisiae","volume":"45","author":"Dickson","year":"2006","journal-title":"Prog Lipid Res"},{"key":"key\n\t\t\t\t20180317043245_bib2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1365-2958.2012.08087.x","article-title":"An essential function of sphingolipids in yeast cell division","volume":"84","author":"Epstein","year":"2012","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180317043245_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-2275(20)39810-2","article-title":"The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa","volume":"21","author":"Hanson","year":"1980","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180317043245_bib4","first-page":"236","article-title":"AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells","volume":"251","author":"Hashida-Okado","year":"1996","journal-title":"Mol Gen Genet"},{"key":"key\n\t\t\t\t20180317043245_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-5793(98)00211-7","article-title":"Transformation system for prototrophic industrial yeasts using the AUR1 gene as a dominant selection marker","volume":"425","author":"Hashida-Okado","year":"1998","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20180317043245_bib6","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1128\/AAC.39.12.2765","article-title":"The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337)","volume":"39","author":"Heidler","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180317043245_bib7","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.bbalip.2014.07.014","article-title":"Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals","volume":"1842","author":"Holic","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180317043245_bib8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/yea.1142","article-title":"A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes","volume":"21","author":"Janke","year":"2004","journal-title":"Yeast"},{"key":"key\n\t\t\t\t20180317043245_bib9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/EC.00021-15","article-title":"Control of plasma membrane permeability by ABC transporters","volume":"14","author":"Khakhina","year":"2015","journal-title":"Eukaryot Cell"},{"key":"key\n\t\t\t\t20180317043245_bib10","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1091\/mbc.11.6.1989","article-title":"Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth","volume":"11","author":"Li","year":"2000","journal-title":"Mol Biol Cell"},{"key":"key\n\t\t\t\t20180317043245_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03779","article-title":"TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids","volume":"3","author":"Muir","year":"2014","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180317043245_bib12","doi-asserted-by":"crossref","first-page":"9809","DOI":"10.1074\/jbc.272.15.9809","article-title":"Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene","volume":"272","author":"Nagiec","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180317043245_bib13","doi-asserted-by":"crossref","first-page":"17376","DOI":"10.1074\/jbc.272.28.17376","article-title":"ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation","volume":"272","author":"Oh","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180317043245_bib14","doi-asserted-by":"crossref","first-page":"19222","DOI":"10.1073\/pnas.1116948108","article-title":"Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae","volume":"108","author":"Roelants","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180317043245_bib15","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/j.1365-2958.2006.05196.x","article-title":"PDR16-mediated azole resistance in Candida albicans","volume":"60","author":"Saidane","year":"2006","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180317043245_bib16","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1091\/mbc.12.11.3417","article-title":"Lag1p and Lac1p are essential for the acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae","volume":"12","author":"Schorling","year":"2001","journal-title":"Mol Biol Cell"},{"key":"key\n\t\t\t\t20180317043245_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/yea.2956","article-title":"The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals","volume":"30","author":"Simova","year":"2013","journal-title":"Yeast"},{"key":"key\n\t\t\t\t20180317043245_bib18","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.7164\/antibiotics.46.1414","article-title":"Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic","volume":"46","author":"Takesako","year":"1993","journal-title":"J Antibiot (Tokyo)"},{"key":"key\n\t\t\t\t20180317043245_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2958.2010.07340.x","article-title":"Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids","volume":"78","author":"Tani","year":"2010","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180317043245_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jb\/mvq090","article-title":"Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae","volume":"148","author":"Tani","year":"2010","journal-title":"J Biochem"},{"key":"key\n\t\t\t\t20180317043245_bib21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbrc.2011.11.138","article-title":"Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae","volume":"417","author":"Tani","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20180317043245_bib22","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1099\/mic.0.000187","article-title":"Alteration of complex sphingolipid composition and its physiological significance in yeast Saccharomyces cerevisiae lacking vacuolar ATPase","volume":"161","author":"Tani","year":"2015","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180317043245_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1574-6968.12535","article-title":"Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae","volume":"358","author":"Toume","year":"2014","journal-title":"FEMS Microbiol Lett"},{"key":"key\n\t\t\t\t20180317043245_bib24","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1194\/jlr.M048637","article-title":"Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae","volume":"55","author":"Uemura","year":"2014","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180317043245_bib25","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1074\/jbc.274.4.1934","article-title":"PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs","volume":"274","author":"van den Hazel","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180317043245_bib26","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1128\/EC.00117-15","article-title":"Saccharomyces cerevisiae is dependent on vesicular traffic between the Golgi apparatus and the vacuole when inositolphosphorylceramide synthase Aur1 is inactivated","volume":"14","author":"Voynova","year":"2015","journal-title":"Eukaryot Cell"},{"key":"key\n\t\t\t\t20180317043245_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1128\/AAC.44.3.651-653.2000","article-title":"Inhibition of inositol phosphorylceramide synthase by aureobasidin A in Candida and Aspergillus species","volume":"44","author":"Zhong","year":"2000","journal-title":"Antimicrob Agents Chemother"}],"container-title":["FEMS Microbiology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsle\/article-pdf\/365\/3\/fnx255\/24395501\/fnx255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T05:02:50Z","timestamp":1660107770000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsle\/article\/doi\/10.1093\/femsle\/fnx255\/4733270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,12,12]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femsle\/fnx255","relation":{},"ISSN":["1574-6968"],"issn-type":[{"value":"1574-6968","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,12,12]]}}}