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In the present study, Caenorhabditis elegans was used as the model host to evaluate M. furfur pathogenicity. Additionally, effects of lactic acid bacteria against M. furfur pathogenicity were evaluated. Compared to Escherichia coli OP50 (OP, control), both live and heat-killed M. furfur reduced the lifespan and body size of C. elegans, although heat-killed M. furfur was less effective than live M. furfur in lifespan shortening. Furthermore, unlike heat-killed M. furfur, live M. furfur disrupted the nematode intestinal barrier. Loss-of-function mutants of nsy-1 and sek-1, which encode components of the MAPK signaling pathway, were susceptible to M. furfur, suggesting their involvement in the defense against M. furfur infection. Expression of genes involved in host defense and of those coding for C-type lectin domain-containing proteins and antimicrobial peptides was upregulated in M. furfur-infected C. elegans. Lacticaseibacillus rhamnosus (LR) significantly ameliorated lifespan shortening and body size reduction in M. furfur-infected C. elegans and protected against intestinal barrier disruption, suggesting that LR protects nematodes from M. furfur virulence. This study highlights M. furfur pathogenicity and intestinal barrier disruptive ability in C. elegans and suggests that the M. furfur virulence is partially attenuated by LR.<\/jats:p>","DOI":"10.1093\/femsmc\/xtag049","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:39:10Z","timestamp":1788867550000},"source":"Crossref","is-referenced-by-count":0,"title":["Pathogenicity and intestinal barrier disruptive ability of\n                    <i>Malassezia furfur<\/i>\n                    in an alternative model host\n                    <i>Caenorhabditis elegans<\/i>\n                    is partially alleviated by\n                    <i>Lacticaseibacillus rhamnosus<\/i>"],"prefix":"10.1093","volume":"7","author":[{"given":"Chiho","family":"Kishida","sequence":"first","affiliation":[{"name":"Graduate School of Human Life and Ecology, Osaka Metropolitan University , Osaka 558-8585 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