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Membrane contact sites (MCS) have been studied in far less detail, but are crucial for \u2018short range\u2019 (10\u201330\u00a0nm) communication between organelles, as well as between pathogen vacuoles and organelles. MCS are specialized in the non-vesicular trafficking of small molecules such as calcium and lipids. Pivotal MCS components important for lipid transfer are the VAP receptor\/tether protein, oxysterol binding proteins (OSBPs), the ceramide transport protein CERT, the phosphoinositide phosphatase Sac1, and the lipid phosphatidylinositol 4-phosphate (PtdIns(4)P). In this review, we discuss how these MCS components are subverted by bacterial pathogens and their secreted effector proteins to promote intracellular survival and replication.<\/jats:p>","DOI":"10.1093\/femsml\/uqad018","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T01:31:02Z","timestamp":1680917462000},"source":"Crossref","is-referenced-by-count":24,"title":["Pathogen vacuole membrane contact sites \u2013 close encounters of the fifth kind"],"prefix":"10.1093","volume":"4","author":[{"given":"Simone","family":"Vormittag","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Z\u00fcrich , Gloriastrasse 30, 8006 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J","family":"Ende","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Cancer Biology, University of Virginia , 1340 Jefferson Park Ave, Charlottesville, VA 22908, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Derr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Cancer Biology, University of Virginia , 1340 Jefferson Park Ave, Charlottesville, VA 22908, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-9301","authenticated-orcid":false,"given":"Hubert","family":"Hilbi","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Z\u00fcrich , Gloriastrasse 30, 8006 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"2023041817403333100_bib1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.femsre.2005.03.002","article-title":"The chlamydial developmental 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