{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:07Z","timestamp":1791272287427,"version":"4.1.0"},"reference-count":136,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["210879364"],"award-info":[{"award-number":["210879364"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Modern medical advances have contributed to a growing population of immunocompromised individuals, increasing susceptibility to human fungal pathogens. The leading species for invasive fungal diseases are Candida albicans and Aspergillus fumigatus. While C. albicans is a common colonizer of mucosal sites that can cause endogenous infections, A. fumigatus is an environmental fungus that typically infects individuals through the inhalation of spores. As a first point of contact, the epithelial cell layers serve both as a physical barrier and a sentinel to alert the immune system. Numerous fungal and host-derived mediators have been described that facilitate fungal adherence, invasion into epithelial cells, and subsequent host tissue damage. In cases of systemic infection, this can lead to fungal dissemination. This review focusses on the early interactions\u2014specifically adhesion and invasion\u2014between epithelial cells and the fungal pathogens C. albicans and A. fumigatus.<\/jats:p>","DOI":"10.1093\/femsml\/uqag001","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:46:28Z","timestamp":1770813988000},"source":"Crossref","is-referenced-by-count":3,"title":["Critical parameters of fungal pathogenicity at the epithelial interphase"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2741-2714","authenticated-orcid":false,"given":"Anna","family":"M\u00f6slinger","sequence":"first","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute Department of Microbial Pathogenicity Mechanisms, , 07745 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Allert","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute Department of Microbial Pathogenicity Mechanisms, , 07745 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavena","family":"Vylkova","sequence":"additional","affiliation":[{"name":"The Benioff Center for Microbiome Medicine, University of California San Francisco , CA 94143 San Francisco, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-0425","authenticated-orcid":false,"given":"Bernhard","family":"Hube","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute Department of Microbial Pathogenicity Mechanisms, , 07745 Jena ,","place":["Germany"]},{"name":"Faculty of Biological Sciences, Institute of Microbiology, Friedrich Schiller University Jena , 07743 Jena ,","place":["Germany"]},{"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena , 07743 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"2026021917114019200_bib1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.alit.2023.08.004","article-title":"Relationship between aspergillus and asthma","volume":"72","author":"Agarwal","year":"2023","journal-title":"Allergol Int"},{"key":"2026021917114019200_bib2","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/bjh.12896","article-title":"Current status of antifungal resistance and its impact on clinical practice","volume":"166","author":"Alcazar-Fuoli","year":"2014","journal-title":"Br J Haematol"},{"key":"2026021917114019200_bib3","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00915-18","article-title":"Candida albicans-induced epithelial damage mediates translocation through intestinal barriers","volume":"9","author":"Allert","year":"2018","journal-title":"mBio"},{"key":"2026021917114019200_bib4","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ijmm.2014.04.009","article-title":"Melanin dependent survival of Apergillus fumigatus conidia in lung epithelial cells","volume":"304","author":"Amin","year":"2014","journal-title":"Int J Med Microbiol"},{"key":"2026021917114019200_bib5","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.4103\/jfmpc.jfmpc_1582_24","article-title":"Invasive fungal infections and the management in immunocompromised conditions","volume":"14","author":"Anandani","year":"2025","journal-title":"J Family Med Prim Care"},{"key":"2026021917114019200_bib6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mib.2020.05.007","article-title":"I want to break free\u2014macrophage strategies to recognize and kill candida albicans, and fungal counter-strategies to escape","volume":"58","author":"Austermeier","year":"2020","journal-title":"Curr Opin Microbiol"},{"key":"2026021917114019200_bib7","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12866-015-0500-y","article-title":"Evidence for the involvement of cofilin in Aspergillus fumigatus internalization into type ii alveolar epithelial cells","volume":"15","author":"Bao","year":"2015","journal-title":"BMC Microbiol"},{"key":"2026021917114019200_bib8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1093\/femsre\/fuy045","article-title":"Microbial uptake by the respiratory epithelium: outcomes for host and pathogen","volume":"43","author":"Bertuzzi","year":"2019","journal-title":"FEMS Microbiol Rev"},{"key":"2026021917114019200_bib9","doi-asserted-by":"publisher","first-page":"109939","DOI":"10.1016\/j.isci.2024.109939","article-title":"Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells","volume":"27","author":"Bertuzzi","year":"2024","journal-title":"iScience"},{"key":"2026021917114019200_bib10","doi-asserted-by":"publisher","first-page":"e1004413","DOI":"10.1371\/journal.ppat.1004413","article-title":"The ph-responsive PACC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis","volume":"10","author":"Bertuzzi","year":"2014","journal-title":"PLoS Pathog"},{"key":"2026021917114019200_bib11","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1128\/IAI.00032-13","article-title":"Role of ficolin-a and lectin complement pathway in the innate defense against pathogenic Aspergillus species","volume":"81","author":"Bidula","year":"2013","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/imm.12501","article-title":"H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses","volume":"146","author":"Bidula","year":"2015","journal-title":"Immunology"},{"key":"2026021917114019200_bib13","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.3390\/ijms25094775","article-title":"Secreted aspartic proteinases: key factors in candida infections and host-pathogen interactions","volume":"25","author":"Bras","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026021917114019200_bib14","doi-asserted-by":"publisher","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"2026021917114019200_bib15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/35092620","article-title":"Immune recognition. A new receptor for beta-glucans","volume":"413","author":"Brown","year":"2001","journal-title":"Nature"},{"key":"2026021917114019200_bib16","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 mediates the biological effects of beta-glucans","volume":"197","author":"Brown","year":"2003","journal-title":"J Exp Med"},{"key":"2026021917114019200_bib17","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.3390\/ijms21072576","article-title":"Lysosomal exocytosis, exosome release and secretory autophagy: the autophagic- and endo-lysosomal systems go extracellular","volume":"21","author":"Buratta","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026021917114019200_bib18","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1086\/526500","article-title":"Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis","volume":"197","author":"Carvalho","year":"2008","journal-title":"J Infect Dis"},{"key":"2026021917114019200_bib19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1164\/rccm.201106-1027OC","article-title":"Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to aspergillus and resultant pulmonary inflammation","volume":"185","author":"Chaudhary","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026021917114019200_bib20","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00663-18","article-title":"Endocytic markers associated with the internalization and processing of Aspergillus fumigatus conidia by beas-2b cells","volume":"4","author":"Clark","year":"2019","journal-title":"mSphere"},{"key":"2026021917114019200_bib21","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1128\/iai.64.11.4514-4519.1996","article-title":"Evidence for degradation of gastrointestinal mucin by candida albicans secretory aspartyl proteinase","volume":"64","author":"Colina","year":"1996","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib22","doi-asserted-by":"publisher","first-page":"7060","DOI":"10.1111\/febs.15731","article-title":"The role of goblet cells in viral pathogenesis","volume":"288","author":"Cortez","year":"2021","journal-title":"FEBS J"},{"key":"2026021917114019200_bib23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1462-5822.2009.01394.x","article-title":"Cellular interactions of candida albicans with human oral epithelial cells and enterocytes","volume":"12","author":"Dalle","year":"2010","journal-title":"Cell Microbiol"},{"key":"2026021917114019200_bib24","doi-asserted-by":"publisher","first-page":"3172","DOI":"10.1128\/IAI.68.6.3172-3179.2000","article-title":"Characterization of binding of candida albicans to small intestinal mucin and its role in adherence to mucosal epithelial cells","volume":"68","author":"de\u00a0Repentigny","year":"2000","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/infdis\/175.1.146","article-title":"Binding and germination of aspergillus fumigatus conidia on cultured a549 pneumocytes","volume":"175","author":"DeHart","year":"1997","journal-title":"J Infect Dis"},{"key":"2026021917114019200_bib26","doi-asserted-by":"publisher","first-page":"2287618","DOI":"10.1080\/19490976.2023.2287618","article-title":"Unveiling candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response","volume":"15","author":"Delavy","year":"2023","journal-title":"Gut Microbes"},{"key":"2026021917114019200_bib27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/1471-2334-14-166","article-title":"Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series","volume":"14","author":"Delsing","year":"2014","journal-title":"BMC Infect Dis"},{"key":"2026021917114019200_bib28","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2026021917114019200_bib29","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1099\/00221287-148-2-497","article-title":"In vitro reconstructed human epithelia reveal contributions of candida albicans efg1 and cph1 to adhesion and invasion","volume":"148","author":"Dieterich","year":"2002","journal-title":"Microbiology"},{"key":"2026021917114019200_bib30","doi-asserted-by":"publisher","first-page":"e54379","DOI":"10.1371\/journal.pone.0054379","article-title":"Characterization of the vaginal micro- and mycobiome in asymptomatic reproductive-age estonian women","volume":"8","author":"Drell","year":"2013","journal-title":"PLoS One"},{"key":"2026021917114019200_bib31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1128\/IAI.73.1.622-626.2005","article-title":"Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in candida albicans-infected human gingival epithelial cells","volume":"73","author":"Egusa","year":"2005","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib32","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/nrmicro1004","article-title":"Antimicrobial reactive oxygen and nitrogen species: concepts and controversies","volume":"2","author":"Fang","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"2026021917114019200_bib33","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1128\/IAI.70.7.3689-3700.2002","article-title":"Candida albicans hyphal formation and the expression of the efg1-regulated proteinases sap4 to sap6 are required for the invasion of parenchymal organs","volume":"70","author":"Felk","year":"2002","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib34","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1093\/infdis\/jiy298","article-title":"Penetration of the human pulmonary epithelium by Aspergillus fumigatus hyphae","volume":"218","author":"Fernandes","year":"2018","journal-title":"J Infect Dis"},{"key":"2026021917114019200_bib35","doi-asserted-by":"publisher","first-page":"3835","DOI":"10.1038\/s41467-018-06148-7","article-title":"Lung colonization by Aspergillus fumigatus is controlled by znf77","volume":"9","author":"Gago","year":"2018","journal-title":"Nat Commun"},{"key":"2026021917114019200_bib36","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/resp.12542","article-title":"Bronchial epithelial cells: the key effector cells in the pathogenesis of chronic obstructive pulmonary disease?","volume":"20","author":"Gao","year":"2015","journal-title":"Respirology"},{"key":"2026021917114019200_bib37","doi-asserted-by":"publisher","first-page":"e1000713","DOI":"10.1371\/journal.ppat.1000713","article-title":"Characterization of the oral fungal microbiome (mycobiome) in healthy individuals","volume":"6","author":"Ghannoum","year":"2010","journal-title":"PLoS Pathog"},{"key":"2026021917114019200_bib38","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/1471-2164-11-358","article-title":"Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus","volume":"11","author":"Gomez","year":"2010","journal-title":"BMC Genomics"},{"key":"2026021917114019200_bib39","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.mib.2012.04.005","article-title":"Importance of the Candida albicans cell wall during commensalism and infection","volume":"15","author":"Gow","year":"2012","journal-title":"Curr Opin Microbiol"},{"key":"2026021917114019200_bib40","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.FUNK-0035-2016","article-title":"The fungal cell wall: structure, biosynthesis, and function","volume":"5","author":"Gow","year":"2017","journal-title":"Microbiol Spectr"},{"key":"2026021917114019200_bib41","doi-asserted-by":"publisher","first-page":"e0149159","DOI":"10.1371\/journal.pone.0149159","article-title":"Intestinal cell tight junctions limit invasion of candida albicans through active penetration and endocytosis in the early stages of the interaction of the fungus with the intestinal barrier","volume":"11","author":"Goyer","year":"2016","journal-title":"PLOS ONE"},{"key":"2026021917114019200_bib42","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.2741\/4281","article-title":"Role of ifn-gamma in immune responses to candida albicans infections","volume":"19","author":"Gozalbo","year":"2014","journal-title":"Front Biosci"},{"key":"2026021917114019200_bib43","doi-asserted-by":"publisher","first-page":"e1003575","DOI":"10.1371\/journal.ppat.1003575","article-title":"Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal beta-glucan from the immune system","volume":"9","author":"Gravelat","year":"2013","journal-title":"PLoS Pathog"},{"key":"2026021917114019200_bib44","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1462-5822.2009.01408.x","article-title":"Aspergillus fumigatus meda governs adherence, host cell interactions and virulence","volume":"12","author":"Gravelat","year":"2010","journal-title":"Cell Microbiol"},{"key":"2026021917114019200_bib45","doi-asserted-by":"publisher","first-page":"e21468","DOI":"10.1371\/journal.pone.0021468","article-title":"Beta-1,3-glucan-induced host phospholipase d activation is involved in Aspergillus fumigatus internalization into type ii human pneumocyte a549 cells","volume":"6","author":"Han","year":"2011","journal-title":"PLoS One"},{"key":"2026021917114019200_bib46","doi-asserted-by":"publisher","first-page":"109392","DOI":"10.1016\/j.celrep.2021.109392","article-title":"Lysmd3: a mammalian pattern recognition receptor for chitin","volume":"36","author":"He","year":"2021","journal-title":"Cell Rep"},{"key":"2026021917114019200_bib47","doi-asserted-by":"publisher","first-page":"913028","DOI":"10.3389\/fimmu.2022.913028","article-title":"Neutrophil extracellular traps in Candida albicans infection","volume":"13","author":"He","year":"2022","journal-title":"Front Immunol"},{"key":"2026021917114019200_bib48","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.tim.2018.01.007","article-title":"Dynamic fungal cell wall architecture in stress adaptation and immune evasion","volume":"26","author":"Hopke","year":"2018","journal-title":"Trends Microbiol"},{"key":"2026021917114019200_bib49","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.chom.2023.02.002","article-title":"Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway","volume":"31","author":"Jia","year":"2023","journal-title":"Cell Host Microbe"},{"key":"2026021917114019200_bib50","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.micinf.2014.03.001","article-title":"Gliotoxin promotes Aspergillus fumigatus internalization into type ii human pneumocyte a549 cells by inducing host phospholipase d activation","volume":"16","author":"Jia","year":"2014","journal-title":"Microbes Infect"},{"key":"2026021917114019200_bib51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1128\/EC.00290-12","article-title":"Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species","volume":"12","author":"Jimenez-Lopez","year":"2013","journal-title":"Eukaryot Cell"},{"key":"2026021917114019200_bib52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11046-022-00631-y","article-title":"Occurrence of cystic fibrosis transmembrane conductance regulator gene mutations in patients with allergic bronchopulmonary aspergillosis complicating asthma","volume":"187","author":"Kanaujia","year":"2022","journal-title":"Mycopathologia"},{"key":"2026021917114019200_bib53","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s11046-024-00834-5","article-title":"Polymorphisms in innate and adaptive immune genes in subjects with allergic bronchopulmonary aspergillosis complicating asthma","volume":"189","author":"Kanaujia","year":"2024","journal-title":"Mycopathologia"},{"key":"2026021917114019200_bib54","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1038\/s41467-018-06607-1","article-title":"The fungal peptide toxin candidalysin activates the nlrp3 inflammasome and causes cytolysis in mononuclear phagocytes","volume":"9","author":"Kasper","year":"2018","journal-title":"Nat Commun"},{"key":"2026021917114019200_bib55","doi-asserted-by":"publisher","first-page":"e0002123","DOI":"10.1128\/mmbr.00021-23","article-title":"Candida albicans and Candida glabrata: global priority pathogens","volume":"88","author":"Katsipoulaki","year":"2024","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026021917114019200_bib56","doi-asserted-by":"publisher","first-page":"e01911","DOI":"10.1128\/mBio.01911-14","article-title":"Mucins suppress virulence traits of Candida albicans","volume":"5","author":"Kavanaugh","year":"2014","journal-title":"mBio"},{"key":"2026021917114019200_bib57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1476-7961-4-3","article-title":"Il-4 alpha chain receptor (il-4ralpha) polymorphisms in allergic bronchopulmonary sspergillosis","volume":"4","author":"Knutsen","year":"2006","journal-title":"Clin Mol Allergy"},{"key":"2026021917114019200_bib58","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1086\/420850","article-title":"Involvement of secreted Aspergillus fumigatus proteases in disruption of the actin fiber cytoskeleton and loss of focal adhesion sites in infected a549 lung pneumocytes","volume":"189","author":"Kogan","year":"2004","journal-title":"J Infect Dis"},{"key":"2026021917114019200_bib59","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/thoraxjnl-2014-206291","article-title":"The clinical spectrum of pulmonary aspergillosis","volume":"70","author":"Kosmidis","year":"2015","journal-title":"Thorax"},{"key":"2026021917114019200_bib60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.912748","article-title":"Candida albicans sap6 initiates oral mucosal inflammation via the protease activated receptor par2","volume":"13","author":"Kumar","year":"2022","journal-title":"Front Immunol"},{"key":"2026021917114019200_bib61","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.FUNK-0014-2016","article-title":"Fungi that infect humans","volume":"5","author":"K\u00f6hler","year":"2017","journal-title":"Microbiol Spectr"},{"key":"2026021917114019200_bib62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31237-z","article-title":"Trans-cellular tunnels induced by the fungal pathogen candida albicans facilitate invasion through successive epithelial cells without host damage","volume":"13","author":"Lachat","year":"2022","journal-title":"Nat Commun"},{"key":"2026021917114019200_bib63","doi-asserted-by":"publisher","first-page":"2004798","DOI":"10.1080\/19490976.2021.2004798","article-title":"Membrane protective role of autophagic machinery during infection of epithelial cells by Candida albicans","volume":"14","author":"Lapaquette","year":"2022","journal-title":"Gut Microbes"},{"key":"2026021917114019200_bib64","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-micro-030117-020406","article-title":"The cell wall of the human fungal pathogen Aspergillus fumigatus: biosynthesis, organization, immune response, and virulence","volume":"71","author":"Latg\u00e9","year":"2017","journal-title":"Annu Rev Microbiol"},{"key":"2026021917114019200_bib65","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18","article-title":"Aspergillus fumigatus and aspergillosis in 2019","volume":"33","author":"Latg\u00e9","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"2026021917114019200_bib66","doi-asserted-by":"publisher","first-page":"100047","DOI":"10.1016\/j.tcsw.2020.100047","article-title":"Scalar nanostructure of the Candida albicans cell wall; a molecular, cellular and ultrastructural analysis and interpretation","volume":"6","author":"Lenardon","year":"2020","journal-title":"Cell Surf"},{"key":"2026021917114019200_bib67","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1128\/EC.2.6.1266-1273.2003","article-title":"Eap1, a Candida albicans gene involved in binding human epithelial cells","volume":"2","author":"Li","year":"2003","journal-title":"Eukaryotic Cell"},{"key":"2026021917114019200_bib68","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1038\/s41564-024-01794-8","article-title":"Sulfated glycosaminoglycans are host epithelial cell targets of the candida albicans toxin candidalysin","volume":"9","author":"Lin","year":"2024","journal-title":"Nat Microbiol"},{"key":"2026021917114019200_bib69","doi-asserted-by":"publisher","first-page":"16211","DOI":"10.1038\/nmicrobiol.2016.211","article-title":"Aspergillus fumigatus cala binds to integrin alpha(5)beta(1) and mediates host cell invasion","volume":"2","author":"Liu","year":"2016","journal-title":"Nat Microbiol"},{"key":"2026021917114019200_bib70","doi-asserted-by":"publisher","first-page":"e1002305","DOI":"10.1371\/journal.ppat.1002305","article-title":"Mechanisms of Candida albicans trafficking to the brain","volume":"7","author":"Liu","year":"2011","journal-title":"PLoS Path"},{"key":"2026021917114019200_bib71","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1101\/gr.187427.114","article-title":"New signaling pathways govern the host response to C. albicans infection in various niches","volume":"25","author":"Liu","year":"2015","journal-title":"Genome Res"},{"key":"2026021917114019200_bib72","doi-asserted-by":"publisher","first-page":"e18394","DOI":"10.1371\/journal.pone.0018394","article-title":"The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension","volume":"6","author":"Martin","year":"2011","journal-title":"PLoS One"},{"key":"2026021917114019200_bib73","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/01443615.2017.1343810","article-title":"High glucose-mediated overexpression of ICAM-1 in human vaginal epithelial cells increases adhesion of Candida albicans","volume":"38","author":"Mikamo","year":"2018","journal-title":"J Obstetrics Gynaecol"},{"key":"2026021917114019200_bib74","doi-asserted-by":"publisher","first-page":"102508","DOI":"10.1016\/j.mib.2024.102508","article-title":"Epithelial responses to fungal pathogens","volume":"80","author":"Mills","year":"2024","journal-title":"Curr Opin Microbiol"},{"key":"2026021917114019200_bib75","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13378","article-title":"Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans","volume":"23","author":"Mogavero","year":"2021","journal-title":"Cell Microbiol"},{"key":"2026021917114019200_bib76","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/toxins17020089","article-title":"Breaking barriers: candidalysin disrupts epithelial integrity and induces inflammation in a gut-on-chip model","volume":"17","author":"Morelli","year":"2025","journal-title":"Toxins"},{"key":"2026021917114019200_bib77","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1574-6968.1997.tb12595.x","article-title":"Degradation of human subendothelial extracellular matrix by proteinase-secreting candida albicans","volume":"153","author":"Morschh\u00e4user","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"2026021917114019200_bib78","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"2026021917114019200_bib79","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41564-024-01606-z","article-title":"Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences","volume":"9","author":"M\u00fcller","year":"2024","journal-title":"Nat Microbiol"},{"key":"2026021917114019200_bib80","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1177\/0022034511399285","article-title":"Epithelial cell innate response to Candida albicans","volume":"23","author":"Naglik","year":"2011","journal-title":"Adv Dent Res"},{"key":"2026021917114019200_bib81","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","article-title":"Candida albicans secreted aspartyl proteinases in virulence and pathogenesis","volume":"67","author":"Naglik","year":"2003","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026021917114019200_bib82","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s40168-017-0373-4","article-title":"The gut mycobiome of the human microbiome project healthy cohort","volume":"5","author":"Nash","year":"2017","journal-title":"Microbiome"},{"key":"2026021917114019200_bib83","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00333-22","article-title":"Aspergillus fumigatus drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis","volume":"91","author":"Okaa","year":"2023","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib84","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.molimm.2018.12.003","article-title":"Antifungal activities of surfactant protein d in an environment closely mimicking the lung lining","volume":"105","author":"Ordonez","year":"2019","journal-title":"Mol Immunol"},{"key":"2026021917114019200_bib85","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13223-016-0152-y","article-title":"Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study","volume":"12","author":"Overton","year":"2016","journal-title":"Allergy Asthma Clin Immunol"},{"key":"2026021917114019200_bib86","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1128\/iai.65.4.1510-1514.1997","article-title":"Internalization of Aspergillus fumigatus conidia by epithelial and endothelial cells","volume":"65","author":"Paris","year":"1997","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib87","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1462-5822.2004.00476.x","article-title":"Role of the fungal ras-protein kinase a pathway in governing epithelial cell interactions during oropharyngeal candidiasis","volume":"7","author":"Park","year":"2005","journal-title":"Cell Microbiol"},{"key":"2026021917114019200_bib88","doi-asserted-by":"publisher","first-page":"230106","DOI":"10.1183\/16000617.0106-2023","article-title":"Airway ciliated cells in adult lung homeostasis and COPD","volume":"32","author":"Petit","year":"2023","journal-title":"Eur Respir Rev"},{"key":"2026021917114019200_bib89","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1371\/journal.pbio.0050064","article-title":"Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells","volume":"5","author":"Phan","year":"2007","journal-title":"PLoS Biol"},{"key":"2026021917114019200_bib90","doi-asserted-by":"publisher","first-page":"e1011579","DOI":"10.1371\/journal.ppat.1011579","article-title":"Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection","volume":"19","author":"Phan","year":"2023","journal-title":"PLoS Pathog"},{"key":"2026021917114019200_bib91","doi-asserted-by":"publisher","first-page":"1182914","DOI":"10.3389\/fmicb.2023.1182914","article-title":"Ssa1-targeted antibody prevents host invasion by Candida albicans","volume":"14","author":"Qiu","year":"2023","journal-title":"Front Microbiol"},{"key":"2026021917114019200_bib92","doi-asserted-by":"publisher","first-page":"907519","DOI":"10.3389\/fcimb.2022.907519","article-title":"Distinct cohorts of Aspergillus fumigatus transcription factors are required for epithelial damage occurring via contact- or soluble effector-mediated mechanisms","volume":"12","author":"Rahman","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2026021917114019200_bib93","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10096-013-2009-3","article-title":"Candida glabrata: a review of its features and resistance","volume":"33","author":"Rodrigues","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2026021917114019200_bib94","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3390\/jof7060468","article-title":"Differential proinflammatory responses to Aspergillus fumigatus by airway epithelial cells in vitro are protease dependent","volume":"7","author":"Rowley","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"2026021917114019200_bib95","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75490","article-title":"The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells","volume":"11","author":"Russell","year":"2022","journal-title":"Elife"},{"key":"2026021917114019200_bib96","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1067\/mai.2003.1395","article-title":"Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis","volume":"111","author":"Saxena","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"2026021917114019200_bib97","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41579-025-01174-x","article-title":"Commensalism and pathogenesis of Candida albicans at the mucosal interface","volume":"23","author":"Schille","year":"2025","journal-title":"Nat Rev Microbiol"},{"key":"2026021917114019200_bib98","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.3389\/fmicb.2020.01955","article-title":"Phagolysosomal survival enables non-lytic hyphal escape and ramification through lung epithelium during Aspergillus fumigatus infection","volume":"11","author":"Seidel","year":"2020","journal-title":"Front Microbiol"},{"key":"2026021917114019200_bib99","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1091\/mbc.e05-07-0617","article-title":"The Aspergillus fumigatus StuA protein governs the up-regulation of a discrete transcriptional program during the acquisition of developmental competence","volume":"16","author":"Sheppard","year":"2005","journal-title":"Mol Biol Cell"},{"key":"2026021917114019200_bib100","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1126\/science.aan0365","article-title":"Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death","volume":"357","author":"Shlezinger","year":"2017","journal-title":"Science"},{"key":"2026021917114019200_bib101","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00025-17","article-title":"The aryl hydrocarbon receptor governs epithelial cell invasion during oropharyngeal candidiasis","volume":"8","author":"Solis","year":"2017","journal-title":"mBio"},{"key":"2026021917114019200_bib102","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1126\/science.283.5407.1535","article-title":"Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1","volume":"283","author":"Staab","year":"1999","journal-title":"Science"},{"key":"2026021917114019200_bib103","doi-asserted-by":"publisher","first-page":"e80842","DOI":"10.1371\/journal.pone.0080842","article-title":"Niche-specific requirement for hyphal wall protein 1 in virulence of Candida albicans","volume":"8","author":"Staab","year":"2013","journal-title":"PLoS ONE"},{"key":"2026021917114019200_bib104","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nature25974","article-title":"Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus","volume":"555","author":"Stappers","year":"2018","journal-title":"Nature"},{"key":"2026021917114019200_bib105","doi-asserted-by":"publisher","first-page":"e1001181","DOI":"10.1371\/journal.ppat.1001181","article-title":"Host cell invasion and virulence mediated by Candida albicans Ssa1","volume":"6","author":"Sun","year":"2010","journal-title":"PLoS Pathog"},{"key":"2026021917114019200_bib106","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1007\/s10096-012-1624-8","article-title":"Dectin-1 is inducible and plays a crucial role in aspergillus-induced innate immune responses in human bronchial epithelial cells","volume":"31","author":"Sun","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2026021917114019200_bib107","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41564-017-0059-5","article-title":"Epha2 is an epithelial cell pattern recognition receptor for fungal \u03b2-glucans","volume":"3","author":"Swidergall","year":"2017","journal-title":"Nat Microbiol"},{"key":"2026021917114019200_bib108","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41589-022-01035-1","article-title":"Mucin o-glycans are natural inhibitors of candida albicans pathogenicity","volume":"18","author":"Takagi","year":"2022","journal-title":"Nat Chem Biol"},{"key":"2026021917114019200_bib109","doi-asserted-by":"publisher","first-page":"e12802","DOI":"10.1111\/cmi.12802","article-title":"Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses","volume":"20","author":"Takahashi-Nakaguchi","year":"2018","journal-title":"Cell Microbiol"},{"key":"2026021917114019200_bib110","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fmicb.2011.00096","article-title":"Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway","volume":"2","author":"Thywissen","year":"2011","journal-title":"Front Microbiol"},{"key":"2026021917114019200_bib111","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1600-065X.2007.00548.x","article-title":"Collaboration between the innate immune receptors dectin-1, tlrs, and nods","volume":"219","author":"Underhill","year":"2007","journal-title":"Immunol Rev"},{"key":"2026021917114019200_bib112","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1099\/jmm.0.005991-0","article-title":"Identification and characterization of a laminin-binding protein of Aspergillus fumigatus: extracellular thaumatin domain protein (AFCALAP)","volume":"58","author":"Upadhyay","year":"2009","journal-title":"J Med Microbiol"},{"key":"2026021917114019200_bib113","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1515\/CCLM.2007.033","article-title":"Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins a (SP-a) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis","volume":"45","author":"Vaid","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"2026021917114019200_bib114","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaf013","article-title":"Vaginal Candida albicans infections: host-pathogen-microbiome interactions","volume":"49","author":"Valentine","year":"2025","journal-title":"FEMS Microbiol Rev"},{"key":"2026021917114019200_bib115","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1093\/femsre\/fuaa027","article-title":"Interactions of microorganisms with host mucins: a focus on candida albicans","volume":"44","author":"Valle","year":"2020","journal-title":"FEMS Microbiol Rev"},{"key":"2026021917114019200_bib116","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/eji.201243168","article-title":"E-cadherin: from epithelial glue to immunological regulator","volume":"43","author":"Van\u00a0den\u00a0Bossche","year":"2013","journal-title":"Eur J Immunol"},{"key":"2026021917114019200_bib117","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1128\/IAI.00054-07","article-title":"Mucosal tissue invasion by Candida albicans is associated with e-cadherin degradation, mediated by transcription factor rim101p and protease sap5p","volume":"75","author":"Villar","year":"2007","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib118","doi-asserted-by":"publisher","first-page":"e1004050","DOI":"10.1371\/journal.ppat.1004050","article-title":"Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation","volume":"10","author":"Wagener","year":"2014","journal-title":"PLoS Pathog"},{"key":"2026021917114019200_bib119","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1080\/13693780400029247","article-title":"Intracellular and extracellular growth of Aspergillus fumigatus","volume":"43 Suppl 1","author":"Wasylnka","year":"2005","journal-title":"Med Mycol"},{"key":"2026021917114019200_bib120","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1128\/IAI.70.6.3156-3163.2002","article-title":"Uptake of Aspergillus fumigatus conidia by phagocytic and nonphagocytic cells in vitro: quantitation using strains expressing green fluorescent protein","volume":"70","author":"Wasylnka","year":"2002","journal-title":"Infect Immun"},{"key":"2026021917114019200_bib121","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1242\/jcs.00329","article-title":"Aspergillus fumigatus conidia survive and germinate in acidic organelles of a549 epithelial cells","volume":"116","author":"Wasylnka","year":"2003","journal-title":"J Cell Sci"},{"key":"2026021917114019200_bib122","doi-asserted-by":"publisher","first-page":"110187","DOI":"10.1016\/j.celrep.2021.110187","article-title":"Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion","volume":"38","author":"Westman","year":"2022","journal-title":"Cell Reports"},{"key":"2026021917114019200_bib123","doi-asserted-by":"publisher","first-page":"S143","DOI":"10.1513\/AnnalsATS.201802-128AW","article-title":"Airway epithelial differentiation and mucociliary clearance","volume":"15","author":"Whitsett","year":"2018","journal-title":"Ann Am Thorac Soc"},{"key":"2026021917114019200_bib124","article-title":"WHO fungal priority pathogens list to guide research, development and public health action","author":"WHO\u00a0Organization","year":"2022"},{"key":"2026021917114019200_bib125","doi-asserted-by":"publisher","first-page":"100072","DOI":"10.1016\/j.tcsw.2022.100072","article-title":"Surfactant protein d inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of aspergillus fumigatus","volume":"8","author":"Wong","year":"2022","journal-title":"Cell Surf"},{"key":"2026021917114019200_bib126","doi-asserted-by":"publisher","first-page":"e36952","DOI":"10.1371\/journal.pone.0036952","article-title":"Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process","volume":"7","author":"W\u00e4chtler","year":"2012","journal-title":"PLoS One"},{"key":"2026021917114019200_bib127","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1097\/CM9.0000000000002786","article-title":"Heterozygous card9 mutation favors the development of allergic bronchopulmonary aspergillosis","volume":"136","author":"Xu","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"2026021917114019200_bib128","first-page":"2419","article-title":"Important factors mediates the adhesion of Aspergillus fumigatus to alveolar epithelial cells with e-cadherin","volume":"8","author":"Xu","year":"2016","journal-title":"Am J Transl Res"},{"key":"2026021917114019200_bib129","first-page":"617","article-title":"E-cadherin mediates adhesion and endocytosis of Aspergillus fumigatus blastospores in human epithelial cells","volume":"125","author":"Xu","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"2026021917114019200_bib130","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1111\/j.1462-5822.2007.01009.x","article-title":"In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination","volume":"9","author":"Zakikhany","year":"2007","journal-title":"Cell Microbiol"},{"key":"2026021917114019200_bib131","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.3389\/fmicb.2019.01345","article-title":"Gliotoxin induces cofilin phosphorylation to promote actin cytoskeleton dynamics and internalization of Aspergillus fumigatus into type ii human pneumocyte cells","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Microbiol"},{"key":"2026021917114019200_bib132","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.micpath.2018.07.007","article-title":"Gliotoxin destructs the pulmonary epithelium barrier function by reducing cofilin oligomer formation to promote the dissolution of actin stress fibers","volume":"123","author":"Zhang","year":"2018","journal-title":"Microb Pathog"},{"key":"2026021917114019200_bib133","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jinf.2004.12.012","article-title":"Interaction of airway epithelial cells (a549) with spores and mycelium of Aspergillus fumigatus","volume":"51","author":"Zhang","year":"2005","journal-title":"J Infect"},{"key":"2026021917114019200_bib134","doi-asserted-by":"publisher","first-page":"1029966","DOI":"10.3389\/fmicb.2022.1029966","article-title":"The advances in the regulation of immune microenvironment by Candida albicans and macrophage cross-talk","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Microbiol"},{"key":"2026021917114019200_bib135","doi-asserted-by":"publisher","first-page":"106473","DOI":"10.1016\/j.intimp.2020.106473","article-title":"FCN-a mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway","volume":"83","author":"Zhu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"2026021917114019200_bib136","doi-asserted-by":"publisher","first-page":"14194","DOI":"10.1073\/pnas.1117676109","article-title":"EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["microLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/microlife\/advance-article-pdf\/doi\/10.1093\/femsml\/uqag001\/66865273\/uqag001.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/microlife\/article-pdf\/doi\/10.1093\/femsml\/uqag001\/66865273\/uqag001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/microlife\/article-pdf\/doi\/10.1093\/femsml\/uqag001\/66865273\/uqag001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:11:48Z","timestamp":1771539108000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/microlife\/article\/doi\/10.1093\/femsml\/uqag001\/8475372"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Kurzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":136,"URL":"https:\/\/doi.org\/10.1093\/femsml\/uqag001","relation":{},"ISSN":["2633-6693"],"issn-type":[{"value":"2633-6693","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"uqag001"}}