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Dysbiosis is one predisposing factor for C. albicans overgrowth, indicating that commensal bacteria limit fungal growth and convey colonization resistance. Phocaeicola vulgatus (formerly classified as Bacteroides) is an abundant gut commensal. We show that P. vulgatus can protect enterocytes in vitro from C. albicans damage. The protective effect is most pronounced if the bacteria pre-colonize host cells 6\u00a0h prior to addition of C. albicans. Colonization of the enterocytes with P. vulgatus leads to reduced adhesion of C. albicans, shorter hyphae, and increased fungal shedding, while the overall fungal burden is not reduced. The protective effect is contact-dependent but can be elicited to some degree by heat-inactivated bacterial cells. Our findings suggest that multiple mechanisms mediate the protective effect, including activation of self-defenses of the host cells to shed the pathogen, as well as a direct antagonistic interaction between the fungi and the bacteria targeting C. albicans filamentation, and thereby hyphae-associated virulence factors.<\/jats:p>","DOI":"10.1093\/femsml\/uqag030","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:16:28Z","timestamp":1786965388000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Phocaeicola vulgatus<\/i>\n                    mpk colonization protects epithelial cells from\n                    <i>Candida albicans<\/i>\n                    infection"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0866-8283","authenticated-orcid":false,"given":"Merle Lisa","family":"Hammer","sequence":"first","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Microbial Immunology , 07745 Jena ,","place":["Germany"]},{"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena , 07745 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Joanna","family":"Niemiec","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Microbial Immunology , 07745 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Baumgarten","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Microbial Immunology , 07745 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Auge","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Natural Product Research and 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