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However, the precise mechanisms of antiapoptotic activity of C. trachomatis still need to be clarified. Pgp3, one of eight plasmid proteins of C. trachomatis, has been identified to be closely associated with chlamydial virulence. In this study, we attempted to explore the effects and the mechanisms of Pgp3 protein on apoptosis in HeLa cells; the results showed that Pgp3 increased Bcl-2\/Bax ratio and prevented caspase-3 activation to suppress apoptosis induced by TNF-\u03b1 and cycloheximide (CHX) through ERK1\/2 pathway activation. Downregulation of DJ-1 with siRNA-DJ-1(si-DJ-1) reduced ERK1\/2 phosphorylation and elevated apoptotic rate significantly in Pgp3-HeLa cells. However, inhibition of ERK1\/2 signal pathway with ERK inhibitor PD98059 had little effect on DJ-1 expression. These findings confirm that plasmid protein Pgp3 contributes to apoptosis resistance through ERK1\/2 signal pathway mediated by upregulation of DJ-1 expression. Therefore, the present study provided novel insights into the role of Pgp3 in apoptosis and suggested that manipulation of the host apoptosis response could be a new approach for the prevention and treatment of C. trachomatis infection.<\/jats:p>","DOI":"10.1093\/femspd\/ftaa003","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T20:09:39Z","timestamp":1579723779000},"source":"Crossref","is-referenced-by-count":18,"title":["Antiapoptotic activity of <i>Chlamydia trachomatis<\/i> Pgp3 protein involves activation of the ERK1\/2 pathway mediated by upregulation of DJ-1 protein"],"prefix":"10.1093","volume":"77","author":[{"given":"Fangzhen","family":"Luo","sequence":"first","affiliation":[{"name":"Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P. 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