{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:18:13Z","timestamp":1789402693260,"version":"build-2803163510"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-AI109275"],"award-info":[{"award-number":["R21-AI109275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Following an episode of cholera, a rapidly dehydrating, watery diarrhea caused by the Gram-negative bacterium, Vibrio cholerae O1, humans mount a robust anti-lipopolysaccharide (LPS) antibody response that is associated with immunity to subsequent re-infection. In neonatal mouse and rabbit models of cholera, passively administered anti-LPS polyclonal and monoclonal (MAb) antibodies reduce V. cholerae colonization of the intestinal epithelia by inhibiting bacterial motility and promoting vibrio agglutination. Here we demonstrate that human anti-LPS IgG MAbs also arrest V. cholerae motility and induce bacterial paralysis. A subset of those MAbs also triggered V. cholerae to secrete an extracellular matrix (ECM). To identify changes in gene expression that accompany antibody exposure and that may account for motility arrest and ECM production, we subjected V. cholerae O1 El Tor to RNA-seq analysis after treatment with ZAC-3 IgG, a high affinity MAb directed against the core\/lipid A region of LPS. We identified &amp;gt;\u00a0160 genes whose expression was altered following ZAC-3 IgG treatment, although canonical outer membrane stress regulons were not among them. ompS (VCA1028), a porin associated with virulence and indirectly regulated by ToxT, and norR (VCA0182), a \u03c354-dependent transcription factor involved in late stages of infection, were two upregulated genes worth noting.<\/jats:p>","DOI":"10.1093\/femspd\/ftaa029","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T03:25:51Z","timestamp":1592882751000},"source":"Crossref","is-referenced-by-count":5,"title":["Transcriptional profiling of <i>Vibrio cholerae<\/i> O1 following exposure to human anti- lipopolysaccharide monoclonal antibodies"],"prefix":"10.1093","volume":"78","author":[{"given":"Danielle E","family":"Baranova","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University at Albany, 1400 Washington Ave, Albany NY 12222"},{"name":"Division of Infectious Diseases, Wadsworth Center, NYS Department of Health, 120 New Scotland Ave, Albany NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G","family":"Willsey","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wadsworth Center, NYS Department of Health, 120 New Scotland Ave, Albany NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara J","family":"Levinson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University at Albany, 1400 Washington Ave, Albany NY 12222"},{"name":"Division of Infectious Diseases, Wadsworth Center, NYS Department of Health, 120 New Scotland Ave, Albany NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Wadsworth Center, NYS Department of Health, 120 New Scotland Ave, Albany NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University at Albany, 1400 Washington Ave, Albany NY 12222"},{"name":"Division of Molecular Genetics, Wadsworth Center, NYS Department of Health, 120 New Scotland Ave, Albany NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-8640","authenticated-orcid":false,"given":"Nicholas J","family":"Mantis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University at Albany, 1400 Washington Ave, Albany NY 12222"},{"name":"Division of Infectious Diseases, Wadsworth Center, NYS Department of Health, 120 New Scotland Ave, Albany NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"2021052204105470900_bib1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/JB.01957-14","article-title":"The Vibrio cholerae Cpx envelope stress response senses and mediates adaptation to low iron","volume":"197","author":"Acosta","year":"2015","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/CVI.00647-15","article-title":"O-Specific Polysaccharide-Specific memory B cell responses in young children, older children, and adults infected with Vibrio cholerae O1 Ogawa in Bangladesh","volume":"23","author":"Aktar","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"2021052204105470900_bib3","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1128\/IAI.61.12.5279-5285.1993","article-title":"Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo","volume":"61","author":"Apter","year":"1993","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/mmi.13884","article-title":"Molecular basis for the differential expression of the global regulator VieA in Vibrio cholerae biotypes directed by H-NS, leuo and quorum sensing","volume":"107","author":"Ayala","year":"2018","journal-title":"Mol Microbiol"},{"key":"2021052204105470900_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.20411\/pai.v5i1.370","article-title":"Passive immunity to Vibrio cholerae O1 afforded by a human monoclonal IgA1 antibody expressed in milk","volume":"5","author":"Baranova","year":"2020","journal-title":"Pathog Immun"},{"key":"2021052204105470900_bib6","doi-asserted-by":"crossref","first-page":"e0190026","DOI":"10.1371\/journal.pone.0190026","article-title":"Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination","volume":"13","author":"Baranova","year":"2018","journal-title":"PLoS One"},{"key":"2021052204105470900_bib7","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1128\/IAI.00398-10","article-title":"Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility","volume":"78","author":"Bishop","year":"2010","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.femsle.2004.08.039","article-title":"Chemotaxis in Vibrio cholerae","volume":"239","author":"Boin","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"2021052204105470900_bib9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0168-9525(00)02086-2","article-title":"Learning new tricks from an old Dog: MalT of the Escherichia coli maltose system is part of a complex regulatory network","volume":"16","author":"Boos","year":"2000","journal-title":"Trends Genet"},{"key":"2021052204105470900_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3389\/fmicb.2020.00739","article-title":"Adaptation of Vibrio cholerae to hypoxic environments","volume":"11","author":"Bueno","year":"2020","journal-title":"Front Microbiol"},{"key":"2021052204105470900_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbadis.2003.08.004","article-title":"Lipopolysaccharides of Vibrio cholerae. I. Physical and chemical characterization","volume":"1639","author":"Chatterjee","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"2021052204105470900_bib12","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0140-6736(17)30559-7","article-title":"Cholera","volume":"390","author":"Clemens","year":"2017","journal-title":"Lancet"},{"key":"2021052204105470900_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/infdis\/145.4.465","article-title":"Magnitude, kinetics, and duration of vibriocidal antibody responses in North Americans after ingestion of Vibrio cholerae","volume":"145","author":"Clements","year":"1982","journal-title":"J Infect Dis"},{"key":"2021052204105470900_bib14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1365-2958.2000.01745.x","article-title":"Phosphorylation of the flagellar regulatory protein FlrC is necessary for Vibrio cholerae motility and enhanced colonization","volume":"35","author":"Correa","year":"2000","journal-title":"Mol Microbiol"},{"key":"2021052204105470900_bib15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2012.01.053","article-title":"Coordinated regulation of accessory genetic elements produces cyclic Di-Nucleotides for V. cholerae virulence","volume":"149","author":"Davies","year":"2012","journal-title":"Cell"},{"key":"2021052204105470900_bib16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1365-2958.1998.00694.x","article-title":"Negative transcriptional regulation of a positive regulator: the expression of MalT, encoding the transcriptional activator of the maltose regulon of Escherichia Coli, is negatively controlled by Mlc","volume":"27","author":"Decker","year":"1998","journal-title":"Mol Microbiol"},{"key":"2021052204105470900_bib17","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1073\/pnas.88.12.5403","article-title":"Regulatory cascade controls virulence in Vibrio cholerae","volume":"88","author":"DiRita","year":"1991","journal-title":"Proc Natl Acad Sci"},{"key":"2021052204105470900_bib1_673_1594478228320","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1128\/IAI.59.12.4310-4317.1991","article-title":"Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector","volume":"59","author":"Donnenberg","year":"1991","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib18","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1128\/JB.00315-08","article-title":"Switching control of expression of PtsG from the Mlc regulon to the NagC regulon","volume":"190","author":"El\u00a0Qaidi","year":"2008","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib19","doi-asserted-by":"crossref","first-page":"e1004649","DOI":"10.1371\/journal.pgen.1004649","article-title":"Comprehensive mapping of the Escherichia Coli flagellar regulatory network","volume":"10","author":"Fitzgerald","year":"2014","journal-title":"PLos Genet"},{"key":"2021052204105470900_bib20","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/S0140-6736(12)60436-X","article-title":"Cholera","volume":"379","author":"Harris","year":"2012","journal-title":"Lancet"},{"key":"2021052204105470900_bib22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/35020000","article-title":"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae","volume":"406","author":"Heidelberg","year":"2000","journal-title":"Nature"},{"key":"2021052204105470900_bib21","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1073\/pnas.95.2.730","article-title":"TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae","volume":"95","author":"H\u00e4se","year":"1998","journal-title":"Proc Natl Acad Sci"},{"key":"2021052204105470900_bib23","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1348-0421.1986.tb03037.x","article-title":"Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor","volume":"30","author":"Iwanaga","year":"1986","journal-title":"Microbiol Immunol"},{"key":"2021052204105470900_bib24","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1128\/CVI.00321-12","article-title":"Comparison of immune responses to the O-Specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera","volume":"19","author":"Johnson","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"2021052204105470900_bib25","doi-asserted-by":"crossref","first-page":"e02021","DOI":"10.1128\/mBio.02021-16","article-title":"Single-cell analysis of the plasmablast response to Vibrio cholerae demonstrates expansion of cross-reactive memory B cells","volume":"7","author":"Kauffman","year":"2016","journal-title":"MBio"},{"key":"2021052204105470900_bib26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0008-6215(00)81047-2","article-title":"Structural studies of the Vibrio cholerae O-Antigen","volume":"100","author":"Kenne","year":"1982","journal-title":"Carbohydr Res"},{"key":"2021052204105470900_bib27","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1099\/mic.0.27649-0","article-title":"Shifts from glucose to certain secondary carbon-sources result in activation of the extracytoplasmic function sigma factor SigmaE in Salmonella entericaserovar typhimurium","volume":"151","author":"Kenyon","year":"2005","journal-title":"Microbiology"},{"key":"2021052204105470900_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0966-842X(00)01721-2","article-title":"The suckling mouse model of cholera","volume":"8","author":"Klose","year":"2000","journal-title":"Trends Microbiol"},{"key":"2021052204105470900_bib29","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1128\/JB.00378-11","article-title":"Protection and attachment of Vibrio cholerae mediated by the toxin-coregulated pilus in the infant mouse model","volume":"193","author":"Krebs","year":"2011","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib33","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1016\/j.vaccine.2016.10.023","article-title":"A monoclonal antibody that targets the conserved Core\/Lipid a region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El tor Vibrio cholerae biotypes","volume":"34","author":"Levinson","year":"2016","journal-title":"Vaccine"},{"key":"2021052204105470900_bib34","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1128\/IAI.02856-14","article-title":"Rapid effects of a protective O-Polysaccharide-Specific monoclonal IgA on Vibrio cholerae agglutination, motility, and surface morphology","volume":"83","author":"Levinson","year":"2015","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jim.2015.04.001","article-title":"Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide","volume":"422","author":"Levinson","year":"2015","journal-title":"J Immunol Methods"},{"key":"2021052204105470900_bib30","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1128\/IAI.62.11.4781-4788.1994","article-title":"The maltose regulon of Vibrio cholerae affects production and secretion of virulence factors","volume":"62","author":"L\u00e5ng","year":"1994","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0882-4010(88)90019-8","article-title":"The maltose-Inducible 43\u00a0KDa major outer membrane protein in Vibrio cholerae is immunogenic and common to different isolates","volume":"5","author":"L\u00e5ng","year":"1988","journal-title":"Microb Pathog"},{"key":"2021052204105470900_bib32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0882-4010(87)90072-6","article-title":"A major outer membrane protein in Vibrio cholerae is maltose-inducible","volume":"3","author":"L\u00e5ng","year":"1987","journal-title":"Microb Pathog"},{"key":"2021052204105470900_bib36","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1093\/nar\/gkt444","article-title":"Computational analysis of bacterial RNA-Seq data","volume":"41","author":"McClure","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2021052204105470900_bib37","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature00778","article-title":"Host-Induced epidemic spread of the cholera bacterium","volume":"417","author":"Merrell","year":"2002","journal-title":"Nature"},{"key":"2021052204105470900_bib38","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/JB.170.6.2575-2583.1988","article-title":"A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires ToxR","volume":"170","author":"Miller","year":"1988","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib39","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1128\/JB.00948-09","article-title":"A novel regulatory protein involved in motility of Vibrio cholerae","volume":"191","author":"Moisi","year":"2009","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib40","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1128\/JB.01952-12","article-title":"Characterizing the Hexose-6-Phosphate transport system of Vibrio cholerae, a utilization system for carbon and phosphate sources","volume":"195","author":"Moisi","year":"2013","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib41","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1128\/IAI.01365-15","article-title":"Cytotoxic and inflammatory responses induced by outer membrane vesicle-associated biologically active proteases from Vibrio cholerae","volume":"84","author":"Mondal","year":"2016","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib42","doi-asserted-by":"crossref","first-page":"e101650","DOI":"10.15252\/embj.2019101650","article-title":"A conserved RNA seed-pairing domain directs small RNA-mediated stress resistance in enterobacteria","volume":"38","author":"Peschek","year":"2019","journal-title":"EMBO J"},{"key":"2021052204105470900_bib43","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/JB.01180-09","article-title":"The El tor biotype of Vibrio cholerae exhibits a growth advantage in the stationary phase in mixed cultures with the classical biotype","volume":"192","author":"Pradhan","year":"2010","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib44","doi-asserted-by":"crossref","first-page":"12860","DOI":"10.1074\/jbc.M611593200","article-title":"PilZ domain proteins bind cyclic diguanylate and regulate diverse processes in Vibrio cholerae","volume":"282","author":"Pratt","year":"2007","journal-title":"J Biol Chem"},{"key":"2021052204105470900_bib45","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1046\/j.1365-2958.2001.02348.x","article-title":"The novel Sigma54- and Sigma28-dependent flagellar gene transcription hierarchy of Vibrio cholerae","volume":"39","author":"Prouty","year":"2001","journal-title":"Mol Microbiol"},{"key":"2021052204105470900_bib46","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1128\/JB.01004-10","article-title":"Constitutive expression of the maltoporin LamB in the absence of OmpR damages the cell envelope","volume":"193","author":"Reimann","year":"2011","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib47","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2958.1994.tb00492.x","article-title":"TcpA pilin sequences and colonization requirements for O1 and O139 Vibrio cholerae","volume":"13","author":"Rhine","year":"1994","journal-title":"Mol Microbiol"},{"key":"2021052204105470900_bib48","doi-asserted-by":"crossref","first-page":"e0007803","DOI":"10.1371\/journal.pntd.0007803","article-title":"Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies","volume":"14","author":"Richards","year":"2020","journal-title":"PLoS NeglTrop Dis"},{"key":"2021052204105470900_bib49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/mi.2014.55","article-title":"Antibody blocks acquisition of bacterial colonization through agglutination","volume":"8","author":"Roche","year":"2015","journal-title":"Mucosal Immunol"},{"key":"2021052204105470900_bib50","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"2021052204105470900_bib51","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.chom.2007.09.004","article-title":"Genes induced late in infection increase fitness of Vibrio cholerae after release into the environment","volume":"2","author":"Schild","year":"2007","journal-title":"Cell Host Microbe"},{"key":"2021052204105470900_bib52","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-Image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"2021052204105470900_bib53","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1128\/JB.00092-09","article-title":"Cell envelope perturbation induces oxidative stress and changes in iron homeostasis in Vibrio cholerae","volume":"191","author":"Sikora","year":"2009","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib54","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nbt1183-784","article-title":"A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria","volume":"1","author":"Simon","year":"1983","journal-title":"Bio\/Technology"},{"key":"2021052204105470900_bib55","doi-asserted-by":"crossref","first-page":"e00013","DOI":"10.1128\/mBio.00013-12","article-title":"The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines","volume":"3","author":"Stern","year":"2012","journal-title":"MBio"},{"key":"2021052204105470900_bib56","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/JB.01007-13","article-title":"Genome-scale analyses of Escherichia Coli and salmonella enterica AraC reveal noncanonical targets and an expanded core regulon","volume":"196","author":"Stringer","year":"2014","journal-title":"J Bacteriol"},{"key":"2021052204105470900_bib57","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/CVI.00003-14","article-title":"Chimeric plantibody passively protects mice against aerosolized ricin challenge","volume":"21","author":"Sully","year":"2014","journal-title":"Clin Vaccine Immunol"},{"key":"2021052204105470900_bib58","doi-asserted-by":"crossref","first-page":"e13122","DOI":"10.1371\/journal.pone.0013122","article-title":"Studies on a novel serine protease of a \u0394hapA\u0394prtV Vibrio cholerae O1 strain and its role in hemorrhagic response in the rabbit Ileal loop model","volume":"5","author":"Syngkon","year":"2010","journal-title":"PLoS One"},{"key":"2021052204105470900_bib59","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1128\/IAI.72.10.6050-6060.2004","article-title":"A Vibrio cholerae classical TcpA amino acid sequence induces protective antibody that binds an area hypothesized to be important for toxin-coregulated pilus structure","volume":"72","author":"Taylor","year":"2004","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0572-2","article-title":"De novo assembly of bacterial transcriptomes from RNA-Seq data","volume":"16","author":"Tjaden","year":"2015","journal-title":"Genome Biol"},{"key":"2021052204105470900_bib61","first-page":"e00626","article-title":"Immunity provided by an outer membrane vesicle cholera vaccine is due to O-Antigen-Specific antibodies inhibiting bacterial motility","volume":"85","author":"Wang","year":"2016","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib62","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1128\/IAI.01008-08","article-title":"GbdR regulates pseudomonas aeruginosa PlcH and PchP transcription in response to choline catabolites","volume":"77","author":"Wargo","year":"2009","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib63","doi-asserted-by":"crossref","first-page":"e00597","DOI":"10.1128\/mSphere.00597-19","article-title":"Vibrio Cholerae at the intersection of immunity and the microbiome","volume":"4","author":"Weil","year":"2019","journal-title":"MSphere"},{"key":"2021052204105470900_bib64","doi-asserted-by":"crossref","first-page":"e00135","DOI":"10.1128\/IAI.00135-18","article-title":"Pulmonary surfactant promotes virulence gene expression and biofilm formation in Klebsiella pneumoniae","volume":"86","author":"Willsey","year":"2018","journal-title":"Infect Immun"},{"key":"2021052204105470900_bib65","doi-asserted-by":"crossref","first-page":"e0213507","DOI":"10.1371\/journal.pone.0213507","article-title":"IgM specific to lipopolysaccharide of Vibrio cholerae is a surrogate antibody isotype responsible for serum vibriocidal activity","volume":"14","author":"Yang","year":"2019","journal-title":"PLoS One"},{"key":"2021052204105470900_bib66","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00670-19","article-title":"Functional specialization in Vibrio cholerae diguanylate cyclases: distinct modes of motility suppression and c-Di-GMP production","volume":"10","author":"Zamorano-S\u00e1nchez","year":"2019","journal-title":"MBio"},{"key":"2021052204105470900_bib67","doi-asserted-by":"crossref","first-page":"20871","DOI":"10.1038\/srep20871","article-title":"Characterization of a natural Triple-Tandem c-Di-GMP riboswitch and application of the Riboswitch-Based Dual-Fluorescence reporter","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci Rep"}],"container-title":["Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/advance-article-pdf\/doi\/10.1093\/femspd\/ftaa029\/33432282\/ftaa029.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/78\/4\/ftaa029\/38097809\/ftaa029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/78\/4\/ftaa029\/38097809\/ftaa029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T04:12:02Z","timestamp":1621656722000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article\/doi\/10.1093\/femspd\/ftaa029\/5863188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femspd\/ftaa029","relation":{},"ISSN":["2049-632X"],"issn-type":[{"value":"2049-632X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,6,1]]},"article-number":"ftaa029"}}