{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:33:56Z","timestamp":1790220836400,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Hangzhou Research Project of 2019-Coronavirus Disease","award":["20202013A01"],"award-info":[{"award-number":["20202013A01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The evidence of long-term clinical dynamic on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA re-positive case are less. We performed a 108 days follow-up on dynamic clinical presentations in a case, who hospitalized three times due to the positive recurrence of SARS-CoV-2 RNA after discharge, to understand the prognosis of the 2019-Coronavirus disease (COVID-19). In this case, positive SARS-CoV-2 recurred even after apparent recovery (normal CT imaging, no clinical symptoms, negative SARS-CoV-2 on stool sample and negative serum IgM test) from COVID-19, viral shedding duration lasted for 65 days, the time from symptom onset to disappearance was up to 95 days. Erythrocyte-associated indicators, liver function and serum lipid metabolism presented abnormal throughout during the observation period. Awareness of atypical presentations such as this one is important to prompt the improvement of the management of COVID-19.<\/jats:p>","DOI":"10.1093\/femspd\/ftaa031","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T15:53:32Z","timestamp":1593186812000},"source":"Crossref","is-referenced-by-count":22,"title":["Positive SARS-CoV-2 RNA recurs repeatedly in a case recovered from COVID-19: dynamic results from 108 days of follow-up"],"prefix":"10.1093","volume":"78","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-bin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-song","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-ying","family":"Niu","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-ming","family":"Sui","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-zhi","family":"Xue","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-fang","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, 2 Hengbu Road, Xihu District, Hangzhou, 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"2021052204105217700_bib1","article-title":"COVID-19: abnormal liver function tests","author":"Cai","year":"2020","journal-title":"J Hepatol"},{"key":"2021052204105217700_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2020.05.003","article-title":"Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China","author":"Chen","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2021052204105217700_bib3","volume-title":"Recovered patient re-hospitalized after positive test: Chinese and Beijing","author":"China Daily Website","year":"2020"},{"key":"2021052204105217700_bib4","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1016\/S0140-6736(02)09291-7","article-title":"Association of a pool of HIV-1 with erythrocytes in vivo: a cohort study","volume":"359","author":"Hess","year":"2002","journal-title":"Lancet"},{"key":"2021052204105217700_bib5","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(20)31042-4","article-title":"Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial","volume":"395","author":"Hung","year":"2020","journal-title":"Lancet"},{"key":"2021052204105217700_bib6","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1001\/jama.2020.2783","article-title":"Positive RT-PCR test results in patients recovered from COVID-19","volume":"323","author":"Lan","year":"2020","journal-title":"JAMA"},{"key":"2021052204105217700_bib7","doi-asserted-by":"crossref","first-page":"758682","DOI":"10.1155\/2013\/758682","article-title":"The role of red blood cells in enhancing or preventing HIV infection and other diseases","volume":"2013","author":"Motswaledi","year":"2013","journal-title":"Biomed Res Int"},{"key":"2021052204105217700_bib8","volume-title":"Diagnosis and treatment protocols of the novel coronavirus pneumonia (trial version 6): Chinese and Beijing","author":"National Health Commission of the People's Republic of China","year":"2020"},{"key":"2021052204105217700_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1423-0127-16-102","article-title":"Blood haemoglobin measurement as a predictive indicator for the progression of HIV\/AIDS in resource-limited setting","volume":"16","author":"Obirikorang","year":"2009","journal-title":"J Biomed Sci"},{"key":"2021052204105217700_bib10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12933-020-01035-2","article-title":"Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19","volume":"19","author":"Ren","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"2021052204105217700_bib11","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cgh.2018.04.023","article-title":"Treatment of dyslipidemia in common liver diseases","volume":"16","author":"Speliotes","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2021052204105217700_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/20014091084227","article-title":"Gamma glutamyl transferase","volume":"38","author":"Whitfield","year":"2001","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2021052204105217700_bib13","first-page":"200343","article-title":"Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing","author":"Xie","year":"2020","journal-title":"Radiology"},{"key":"2021052204105217700_bib14","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41422-020-0318-5","article-title":"Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient","volume":"30","author":"Yao","year":"2020","journal-title":"Cell Res"},{"key":"2021052204105217700_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S2468-1253(20)30057-1","article-title":"Liver injury in COVID-19: management and challenges","volume":"5","author":"Zhang","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2021052204105217700_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/15284336.2018.1514821","article-title":"Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults","volume":"19","author":"Zhang","year":"2018","journal-title":"HIV Clin Trials"},{"key":"2021052204105217700_bib17","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"}],"container-title":["Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/advance-article-pdf\/doi\/10.1093\/femspd\/ftaa031\/33437607\/ftaa031.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/78\/4\/ftaa031\/38097763\/ftaa031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/78\/4\/ftaa031\/38097763\/ftaa031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T04:11:40Z","timestamp":1621656700000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article\/doi\/10.1093\/femspd\/ftaa031\/5863936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femspd\/ftaa031","relation":{},"ISSN":["2049-632X"],"issn-type":[{"value":"2049-632X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,6,1]]},"article-number":"ftaa031"}}