{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:36:45Z","timestamp":1769729805121,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670085"],"award-info":[{"award-number":["81670085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309702"],"award-info":[{"award-number":["2017YFC1309702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Aspergillus fumigatus is one of the most common fungal infections involved in the pulmonary diseases. Hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) is important for antifungal immunity. Diabetes is a risk factor of pulmonary A. fumigatus infection and could affect the expression of HIF-1\u03b1. The aim of this investigation was to evaluate the role of HIF-1\u03b1 in pulmonary A. fumigatus infection in diabetes. In murine model, we found diabetic mice had aggravated pulmonary A. fumigatus infection and declined expression of HIF-1\u03b1\u00a0following pulmonary A. fumigatus infection. And these changes could be corrected by dimethyloxalylglycine (DMOG), the agonist of HIF-1\u03b1. In cell experiment, after A. fumigatus stimulation, hyperglycemic state was with a decreased HIF-1\u03b1 expression and increased NLRP3\/IL-1\u03b2 signal pathway. The percentages of Th1 and Treg cells decreased, while percentages of Th2 and Th17 increased in hyperglycemic group. DMOG suppressed A. fumigatus-stimulated NLRP3 and IL-1\u03b2 expressions in hyperglycemic group and corrected Th and Treg cells differentiation. These regulatory effects of DMOG could be dampened by activating of NLRP3. These data indicated that hyperglycemia suppressed the regulatory effect of HIF-1\u03b1 in pulmonary A. fumigatus infection, which can affect Th and Treg cells differentiation by regulating the NLRP3\/IL-1\u03b2 signal pathway.<\/jats:p>","DOI":"10.1093\/femspd\/ftaa038","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T11:10:49Z","timestamp":1594897849000},"source":"Crossref","is-referenced-by-count":11,"title":["Hyperglycemia suppresses the regulatory effect of hypoxia-inducible factor-1\u03b1 in pulmonary <i>Aspergillus fumigatus<\/i> infection"],"prefix":"10.1093","volume":"78","author":[{"given":"Yao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, 110000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"2021052302285849000_bib1","doi-asserted-by":"crossref","first-page":"19426","DOI":"10.1073\/pnas.0805230105","article-title":"Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice","volume":"105","author":"Botusan","year":"2008","journal-title":"Proc Natl Acad Sci 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