{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:57:13Z","timestamp":1791863833923,"version":"4.3.4"},"reference-count":216,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>There is no effective vaccine against malaria; therefore, chemotherapy is to date the only choice to fight against this infectious disease. However, there is growing evidences of drug-resistance mechanisms in malaria treatments. Therefore, the identification of new drug targets is an urgent need for the clinical management of the disease. Proteomic approaches offer the chance of determining the effects of antimalarial drugs on the proteome of Plasmodium parasites. Accordingly, we reviewed the effects of antimalarial drugs on the Plasmodium falciparum proteome pointing out the relevance of several proteins as possible drug targets in malaria treatment. In addition, some of the P. falciparum stage-specific altered proteins and parasite\u2013host interactions might play important roles in pathogenicity, survival, invasion and metabolic pathways and thus serve as potential sources of drug targets. In this review, we have identified several proteins, including thioredoxin reductase, helicases, peptidyl-prolyl cis\u2013trans isomerase, endoplasmic reticulum-resident calcium-binding protein, choline\/ethanolamine phosphotransferase, purine nucleoside phosphorylase, apical membrane antigen 1, glutamate dehydrogenase, hypoxanthine guanine phosphoribosyl transferase, heat shock protein 70x, knob-associated histidine-rich protein and erythrocyte membrane protein 1, as promising antimalarial drugs targets. Overall, proteomic approaches are able to partially facilitate finding possible drug targets. However, the integration of other \u2018omics\u2019 and specific pharmaceutical techniques with proteomics may increase the therapeutic properties of the critical proteins identified in the P. falciparum proteome.<\/jats:p>","DOI":"10.1093\/femspd\/ftaa071","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T20:11:12Z","timestamp":1605298272000},"source":"Crossref","is-referenced-by-count":11,"title":["A proteomic glimpse into the effect of antimalarial drugs on<i>Plasmodium falciparum<\/i>proteome towards highlighting possible therapeutic targets"],"prefix":"10.1093","volume":"79","author":[{"given":"Majid","family":"Dousti","sequence":"first","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Manzano-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Proteomics Unit, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), 37007, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4675-7274","authenticated-orcid":false,"given":"Sajad","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Barzegar","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar Bavarsad","family":"Ahmadpour","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Komijan Treatment and Health Network, Arak University of Medical Science, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7807-4793","authenticated-orcid":false,"given":"Gholamreza","family":"Hatam","sequence":"additional","affiliation":[{"name":"Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"2021010923441564600_bib1","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/prca.200900090","article-title":"A glimpse into the clinical proteome of human malaria parasites Plasmodium falciparum and Plasmodium 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