{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:26:02Z","timestamp":1784280362518,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100018883","name":"Maurice Wilkins Centre for Molecular Biodiscovery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018883","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart Foundation"},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI50666"],"award-info":[{"award-number":["AI50666"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI083683"],"award-info":[{"award-number":["AI083683"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Acute rheumatic fever (ARF) is a serious post-infectious immune sequelae of Group A streptococcus (GAS). Pathogenesis remains poorly understood, including the events associated with collagen autoantibody generation. GAS express streptococcal collagen-like proteins (Scl) that contain a collagenous domain resembling human collagen. Here, the relationship between antibody reactivity to GAS Scl proteins and human collagen in ARF was investigated. Serum IgG specific for a representative Scl protein (Scl1.1) together with collagen-I and collagen-IV mimetic peptides were quantified in ARF patients (n\u00a0=\u00a036) and healthy matched controls (n\u00a0=\u00a036). Reactivity to Scl1.1 was significantly elevated in ARF compared to controls (P &amp;lt; 0.0001) and this was mapped to the collagen-like region of the protein, rather than the N-terminal non-collagenous region. Reactivity to collagen-1 and collagen-IV peptides was also significantly elevated in ARF cases (P &amp;lt; 0.001). However, there was no correlation between Scl1.1 and collagen peptide antibody binding, and hierarchical clustering of ARF cases by IgG reactivity showed two distinct clusters, with Scl1.1 antigens in one and collagen peptides in the other, demonstrating that collagen autoantibodies are not immunologically related to those targeting Scl1.1. Thus, anti-collagen antibodies in ARF appear to be generated as part of the autoreactivity process, independent of any mimicry with GAS collagen-like proteins.<\/jats:p>","DOI":"10.1093\/femspd\/ftab033","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T11:10:26Z","timestamp":1624705826000},"source":"Crossref","is-referenced-by-count":13,"title":["Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients"],"prefix":"10.1093","volume":"79","author":[{"given":"Devaki H","family":"Pilapitiya","sequence":"first","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W R","family":"Harris","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"},{"name":"School of Biological Sciences, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Hanson-Manful","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"McGregor","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M","family":"Raynes","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren H","family":"Carlton","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwick C J","family":"Dobson","sequence":"additional","affiliation":[{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"},{"name":"Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand"},{"name":"Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G","family":"Baker","sequence":"additional","affiliation":[{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"},{"name":"Department of Public Health, University of Otago, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Brimble","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Lukomski","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-637X","authenticated-orcid":false,"given":"Nicole J","family":"Moreland","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Auckland, Auckland, New Zealand"},{"name":"Maurice Wilkins Centre for Biodiscovery, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"2021111806040572300_bib1","first-page":"59","article-title":"Rheumatic fever diagnosis, management, and secondary prevention: a New Zealand guideline","volume":"121","author":"Atatoa-Carr","year":"2008","journal-title":"N Z Med J"},{"key":"2021111806040572300_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16224515","article-title":"Risk factors for acute rheumatic fever: literature review and protocol for a case-control study in New 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