{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T23:48:55Z","timestamp":1773532135868,"version":"3.50.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Neisseria meningitis (Nm) is a human-specific bacterial pathogen that can cause sepsis and meningitis. To cause meningitis Nm must enter the central nervous system (CNS) across one of the barriers between the blood and the brain. We have previously shown that a capsule-depleted Serogroup B strain of Nm displays enhanced invasion into human choroid plexus (CP) epithelial papilloma (HIBCPP) cells, which represent an in vitro model of the blood\u2013cerebrospinal fluid barrier (BCSFB). Still, the processes involved during CNS invasion by Nm, especially the role of host cell actin cytoskeleton remodeling, are not investigated in detail. Here, we demonstrate that invasion into CP epithelial cells by encapsulated and capsule-depleted Nm is mediated by distinct host cell pathways. Whereas a Serogroup B wild-type strain enters HIBCPP cells by a possibly dynamin-independent, but actin related protein 2\/3 (Arp2\/3)-dependent mechanism, invasion by a capsule-depleted mutant is reduced by the dynamin inhibitor dynasore and Arp2\/3-independent. Both wild-type and mutant bacteria require Src kinase activity for entry into HIBCPP cells. Our data show that Nm can employ different mechanisms for invasion into the CP epithelium dependent on the presence of a capsule.<\/jats:p>","DOI":"10.1093\/femspd\/ftab042","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T11:19:24Z","timestamp":1629199164000},"source":"Crossref","is-referenced-by-count":12,"title":["Invasion of the choroid plexus epithelium by<i>Neisseria meningitidis<\/i>is differently mediated by Arp2\/3 signaling and possibly by dynamin dependent on the presence of the capsule"],"prefix":"10.1093","volume":"79","author":[{"given":"Rosanna","family":"Herold","sequence":"first","affiliation":[{"name":"Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"S\u00fcnwoldt","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Stump-Guthier","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Weiss","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Department of Medical Statistics and Biomathematics, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Laboratory of Clinical Regenerative Medicine, Department of Neurosurgery, University of Tsukuba, 1-1-1Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Schroten","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Adam","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-0259","authenticated-orcid":false,"given":"Christian","family":"Schwerk","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, Department of Pediatrics and Infectious Diseases, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, 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