{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:44:11Z","timestamp":1775522651030,"version":"3.50.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["VIR\/Fellowship\/40\/2019\/ECD-I"],"award-info":[{"award-number":["VIR\/Fellowship\/40\/2019\/ECD-I"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Hyperendemic circulation of all four Dengue virus (DENV) serotypes is a severe global public health problem, so any vaccine or therapeutics should be able to target all four of them. Cells of hemopoietic origin are believed to be primary sites of DENV replication. This study aimed to identify potential host miRNAs that target 3' UTR of all four DENV serotypes, thereby directly regulating viral gene expression or indirectly modulating the host system at different virus infection steps. We used four prediction algorithms viz. miRanda, RNA22, RNAhybrid and StarMir for predicting miRNA, targeting 3'UTR of all four DENV serotypes. Statistically, the most significant miRNA targets were screened based on their Log10 P-value (&amp;gt; 0.0001) of Gene Ontology (GO) term and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analysis.<\/jats:p>\n               <jats:p>The intersection test of at least three prediction tools identified a total of 30 miRNAs, which could bind to 3'UTR of all four DENV serotypes. Of the 30, eight miRNAs were of hematopoietic cell origin. GO term enrichment and KEGG analysis showed four hemopoietic origin miRNAs target genes of the biological processes mainly involved in the innate immune response, mRNA 3'-end processing, antigen processing and presentation and nuclear-transcribed mRNA catabolic process.<\/jats:p>","DOI":"10.1093\/femspd\/ftab050","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T11:48:50Z","timestamp":1633088930000},"source":"Crossref","is-referenced-by-count":9,"title":["A bioinformatics approach to investigate serum and hematopoietic cell-specific therapeutic microRNAs targeting the 3' UTRs of all four Dengue virus serotypes"],"prefix":"10.1093","volume":"79","author":[{"given":"Mirza Sarwar","family":"Baig","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, School of Interdisciplinary Sciences & Technology, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-2044","authenticated-orcid":false,"given":"Anuja","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Interdisciplinary Sciences & Technology, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"2021101901533413700_bib1","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"2021101901533413700_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jinf.2014.10.017","article-title":"Differences in serum microRNA profiles in hepatitis B and C virus infection","volume":"70","author":"Akamatsu","year":"2015","journal-title":"J Infect"},{"key":"2021101901533413700_bib3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"2021101901533413700_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek","year":"2008","journal-title":"Nature"},{"key":"2021101901533413700_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2021101901533413700_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"2021101901533413700_bib7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"2021101901533413700_bib8","doi-asserted-by":"crossref","first-page":"e00364","DOI":"10.1128\/JVI.00364-19","article-title":"Interferon-inducible microRNA miR-128 modulates HIV-1 replication by targeting TNPO3 mRNA","volume":"93","author":"Bochnakian","year":"2019","journal-title":"J Virol"},{"key":"2021101901533413700_bib9","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1371\/journal.pbio.0030085","article-title":"Principles of microRNA-target recognition","volume":"3","author":"Brennecke","year":"2005","journal-title":"PLoS Biol"},{"key":"2021101901533413700_bib10","doi-asserted-by":"crossref","first-page":"e110782","DOI":"10.1371\/journal.pone.0110782","article-title":"A serum microRNA signature is associated with the immune control of chronic hepatitis B virus infection","volume":"9","author":"Brunetto","year":"2014","journal-title":"PLoS ONE"},{"key":"2021101901533413700_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12879-016-1364-y","article-title":"Complex interaction between dengue virus replication and expression of miRNA-133a","volume":"16","author":"Castillo","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2021101901533413700_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/0074-02760160404","article-title":"Overexpression of miR-484 and miR-744 in Vero cells alters dengue virus replication","volume":"112","author":"Castrill\u00f3n-Betancur","year":"2017","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"2021101901533413700_bib13","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1056\/NEJMp058190","article-title":"MicroRNAs as oncogenes and tumor suppressors","volume":"353","author":"Chen","year":"2005","journal-title":"N Engl J Med"},{"key":"2021101901533413700_bib14","first-page":"366","article-title":"Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever","volume":"69","author":"Chen","year":"2014","journal-title":"J Inf Secur"},{"key":"2021101901533413700_bib15","doi-asserted-by":"crossref","first-page":"D296","DOI":"10.1093\/nar\/gkx1067","article-title":"miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions","volume":"46","author":"Chou","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib72_1634011226823","doi-asserted-by":"crossref","first-page":"e0005981","DOI":"10.1371\/journal.pntd.0005981","article-title":"MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression. PLoS Negl","volume":"11","author":"Diosa-Toro","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2021101901533413700_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1101\/gad.1064703","article-title":"siRNAs can function as miRNAs","volume":"17","author":"Doench","year":"2003","journal-title":"Genes Dev"},{"key":"2021101901533413700_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12879-016-1656-2","article-title":"Patterns and causes of liver involvement in acute dengue infection","volume":"16","author":"Fernando","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2021101901533413700_bib19","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1101\/gad.1444206","article-title":"A 5\u2019 RNA element promotes dengue virus RNA synthesis on a circular genome","volume":"20","author":"Filomatori","year":"2006","journal-title":"Genes Dev"},{"key":"2021101901533413700_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2105-8-69","article-title":"Inference of miRNA targets using evolutionary conservation and pathway analysis","volume":"8","author":"Gaidatzis","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"2021101901533413700_bib22","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3390\/v3091739","article-title":"Functional RNA elements in the dengue virus genome","volume":"3","author":"Gebhard","year":"2011","journal-title":"Viruses"},{"key":"2021101901533413700_bib23","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","article-title":"Serum microRNAs are promising novel biomarkers","volume":"3","author":"Gilad","year":"2008","journal-title":"PLoS ONE"},{"key":"2021101901533413700_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing","volume":"27","author":"Grimson","year":"2007","journal-title":"Mol Cell"},{"key":"2021101901533413700_bib25","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"2021101901533413700_bib26","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1128\/JVI.02386-12","article-title":"Increasing expression of microRNA 181 inhibits porcine reproductive and respiratory syndrome virus replication and has implications for controlling virus infection","volume":"87","author":"Guo","year":"2013","journal-title":"J Virol"},{"key":"2021101901533413700_bib27","first-page":"421","article-title":"Neutralization and antibody-dependent enhancement of dengue viruses","volume-title":"The Flaviviruses: Pathogenesis and Immunity","author":"Halstead","year":"2003"},{"key":"2021101901533413700_bib28","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human microRNA targets","volume":"2","author":"John","year":"2004","journal-title":"PLoS Biol"},{"key":"2021101901533413700_bib29","doi-asserted-by":"crossref","first-page":"9290","DOI":"10.1093\/nar\/gkx706","article-title":"A comprehensive, cell specific microRNA catalogue of human peripheral blood","volume":"45","author":"Juzenas","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.antiviral.2017.03.020","article-title":"miR-21 promotes dengue virus serotype 2 replication in HepG2 cells","volume":"142","author":"Kanokudom","year":"2017","journal-title":"Antiviral Res"},{"key":"2021101901533413700_bib31","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-6433-8_6","article-title":"STarMir tools for prediction of microRNA binding sites","volume-title":"RNA Structure Determination Methods in Molecular Biology","author":"Kanoria","year":"2016"},{"key":"2021101901533413700_bib32","doi-asserted-by":"crossref","first-page":"D239","DOI":"10.1093\/nar\/gkx1141","article-title":"DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA-gene interactions","volume":"46","author":"Karagkouni","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib33","doi-asserted-by":"crossref","first-page":"144300","DOI":"10.1016\/j.gene.2019.144300","article-title":"Vector derived artificial miRNA mediated inhibition of West Nile virus replication and protein expression","volume":"729","author":"Karothia","year":"2020","journal-title":"Gene"},{"key":"2021101901533413700_bib34","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"Kertesz","year":"2007","journal-title":"Nat Genet"},{"key":"2021101901533413700_bib36","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1101\/gad.1184704","article-title":"A combined computational-experimental approach predicts human microRNA targets","volume":"18","author":"Kiriakidou","year":"2004","journal-title":"Genes Dev"},{"key":"2021101901533413700_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1261\/rna.5191904","article-title":"Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes","volume":"10","author":"Lai","year":"2004","journal-title":"RNA"},{"key":"2021101901533413700_bib38","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Lewis","year":"2003","journal-title":"Cell"},{"key":"2021101901533413700_bib39","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Lewis","year":"2003","journal-title":"Cell"},{"key":"2021101901533413700_bib40","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1101\/gad.1074403","article-title":"The microRNAs of Caenorhabditis elegans","volume":"17","author":"Lim","year":"2003","journal-title":"Genes Dev"},{"key":"2021101901533413700_bib41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.celrep.2017.09.030","article-title":"Host microRNAs-221 and -222 inhibit HIV-1 entry in macrophages by targeting the CD4 viral receptor","volume":"21","author":"Lodge","year":"2017","journal-title":"Cell Rep"},{"key":"2021101901533413700_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nsmb1226","article-title":"Potent effect of target structure on microRNA function","volume":"14","author":"Long","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"2021101901533413700_bib43","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1093\/nar\/gkw116","article-title":"Distribution of miRNA expression across human tissues","volume":"44","author":"Ludwig","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/1471-2105-10-295","article-title":"Accurate microRNA target prediction correlates with protein repression levels","volume":"10","author":"Maragkakis","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2021101901533413700_bib45","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"2021101901533413700_bib46","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"2021101901533413700_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1067","article-title":"A structural perspective of the flavivirus life cycle","volume":"3","author":"Mukhopadhyay","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"2021101901533413700_bib49","doi-asserted-by":"crossref","first-page":"e95920","DOI":"10.1371\/journal.pone.0095920","article-title":"MicroRNA-150 is a potential biomarker of HIV\/AIDS disease progression and therapy","volume":"9","author":"Munshi","year":"2014","journal-title":"PLoS ONE"},{"key":"2021101901533413700_bib50","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3892\/etm.2016.3121","article-title":"Efficient inhibition of human immunodeficiency virus replication using novel modified microRNA-30a targeting 3'-untranslated region transcripts","volume":"11","author":"Nejati","year":"2016","journal-title":"Exp Therap Med"},{"key":"2021101901533413700_bib51","article-title":"DIANA-TarBase and DIANA suite tools: studying experimentally supported microRNA targets","volume":"55","author":"Paraskevopoulou","year":"2016","journal-title":"CurrProtoc Bioinformatics"},{"key":"2021101901533413700_bib52","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1038\/onc.2010.59","article-title":"Targeting of mRNAs by multiple miRNAs: the next step","volume":"29","author":"Peter","year":"2010","journal-title":"Oncogene"},{"key":"2021101901533413700_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1002465","article-title":"Replication in cells of hematopoietic origin is necessary for dengue virus dissemination","volume":"8","author":"Pham","year":"2012","journal-title":"PLoS Pathog"},{"key":"2021101901533413700_bib54","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/ng1798","article-title":"microRNA target predictions in animals","volume":"38","author":"Rajewsky","year":"2006","journal-title":"Nat Genet"},{"key":"2021101901533413700_bib55","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1261\/rna.5248604","article-title":"Fast and effective prediction of microRNA\/target duplexes","volume":"10","author":"Rehmsmeier","year":"2004","journal-title":"RNA"},{"key":"2021101901533413700_bib56","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/nar\/gkm133","article-title":"Distance constraints between microRNA target sites dictate efficacy and cooperativity","volume":"35","author":"Saetrom","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib57","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.nbt.2010.02.016","article-title":"MicroRNAs\u2013targeting and target prediction","volume":"27","author":"Saito","year":"2010","journal-title":"New Biotechnol"},{"key":"2021101901533413700_bib58","doi-asserted-by":"crossref","DOI":"10.1097\/CM9.0000000000001100","article-title":"Serum microRNA expression profiling revealing potential diagnostic biomarkers for lung adenocarcinoma","volume":"133","author":"Shan","year":"2020","journal-title":"Chin Med J"},{"key":"2021101901533413700_bib71_1634011076856","doi-asserted-by":"crossref","first-page":"e02388","DOI":"10.1128\/JVI.02388-16","article-title":"A MicroRNA screen identifies the Wnt Signaling pathway as a regulator of the interferon response during Flavivirus infection","volume":"91","author":"Smith","year":"2017","journal-title":"J Virol"},{"key":"2021101901533413700_bib59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.semcancer.2008.01.005","article-title":"MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation","volume":"18","author":"Sonkoly","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"2021101901533413700_bib62","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib63","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1111\/j.1365-2893.2011.01536.x","article-title":"Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection","volume":"19","author":"Waidmann","year":"2012","journal-title":"J Viral Hepat"},{"key":"2021101901533413700_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12929-018-0482-9","article-title":"The monocyte-macrophage-mast cell axis in dengue pathogenesis","volume":"25","author":"Wan","year":"2018","journal-title":"J Biomed Sci"},{"key":"2021101901533413700_bib65","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1111\/jcmm.13219","article-title":"The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome","volume":"21","author":"Wang","year":"2017","journal-title":"J Cell Mol Med"},{"key":"2021101901533413700_bib73_1634011583744","first-page":"631","article-title":"Cellular microRNA-miR-548g-3p modulates the replication of dengue virus","volume":"70","author":"Weitao","year":"2015","journal-title":"J Inf Secur"},{"key":"2021101901533413700_bib66","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/156652411794859250","article-title":"Practical aspects of microRNA target prediction","volume":"11","author":"Witkos","year":"2011","journal-title":"Curr Mol Med"},{"key":"2021101901533413700_bib67","first-page":"329","article-title":"miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6","volume":"67","author":"Wu","year":"2013","journal-title":"J Inf Secur"},{"key":"2021101901533413700_bib68","doi-asserted-by":"crossref","first-page":"D105","DOI":"10.1093\/nar\/gkn851","article-title":"miRecords: an integrated resource for microRNA-target interactions","volume":"37","author":"Xiao","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2021101901533413700_bib70","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/jmv.23815","article-title":"miR-252 of the Asian tiger mosquito Aedes albopictus regulates dengue virus replication by suppressing the expression of the dengue virus envelope protein","volume":"86","author":"Yan","year":"2014","journal-title":"J Med Virol"},{"key":"2021101901533413700_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12985-016-0562-y","article-title":"miR-124 attenuates Japanese encephalitis virus replication by targeting DNM2","volume":"13","author":"Yang","year":"2016","journal-title":"Virol J"},{"key":"2021101901533413700_bib72","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/cid\/cix766","article-title":"Dependency of vaccine efficacy on preexposure and age: a closer look at a tetravalent dengue vaccine","volume":"66","author":"Yang","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021101901533413700_bib73","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.virol.2007.12.035","article-title":"Specific requirements for elements of the 5' and 3' terminal regions in flavivirus RNA synthesis and viral replication","volume":"374","author":"Yu","year":"2008","journal-title":"Virology"},{"key":"2021101901533413700_bib74","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.1128\/JVI.72.9.7510-7522.1998","article-title":"Identification of specific nucleotide sequences within the conserved 3\u2019-SL in the dengue type 2 virus genome required for replication","volume":"72","author":"Zeng","year":"1998","journal-title":"J Virol"},{"key":"2021101901533413700_bib75","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1099\/jgv.0.001320","article-title":"Cellular microRNA miR-c89 inhibits replication of porcine reproductive and respiratory syndrome virus by targeting the host factor porcine retinoid X receptor \u03b2","volume":"100","author":"Zhang","year":"2019","journal-title":"J Gen Virol"},{"key":"2021101901533413700_bib76","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1128\/JVI.02655-12","article-title":"Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome","volume":"87","author":"Zheng","year":"2013","journal-title":"J Virol"}],"container-title":["Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/advance-article-pdf\/doi\/10.1093\/femspd\/ftab050\/40510646\/ftab050.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/79\/8\/ftab050\/40724660\/ftab050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/79\/8\/ftab050\/40724660\/ftab050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:42:10Z","timestamp":1634769730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article\/doi\/10.1093\/femspd\/ftab050\/6381691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,10,18]]}},"URL":"https:\/\/doi.org\/10.1093\/femspd\/ftab050","relation":{},"ISSN":["2049-632X"],"issn-type":[{"value":"2049-632X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11]]},"published":{"date-parts":[[2021,10,5]]},"article-number":"ftab050"}}