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These permeable blood vessels aid mycobacterial growth, as antiangiogenic or vascular normalizing therapies are beneficial host-directed therapies in preclinical models of tuberculosis across host-mycobacterial pairings. Using the zebrafish\u2013Mycobacterium marinum infection model, we demonstrate that vascular normalization by inhibition of vascular endothelial protein tyrosine phosphatase (VE-PTP) decreases granuloma hypoxia, the opposite effect of hypoxia-inducing antiangiogenic therapy. Inhibition of VE-PTP decreased neutrophil recruitment to granulomas in adult and larval zebrafish, and decreased the proportion of neutrophils that extravasated distal to granulomas. Furthermore, VE-PTP inhibition increased the accumulation of T cells at M. marinum granulomas. Our study provides evidence that, similar to the effect in solid tumors, vascular normalization during mycobacterial infection increases the T cell:neutrophil ratio in lesions which may be correlates of protective immunity.<\/jats:p>","DOI":"10.1093\/femspd\/ftac009","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T07:14:04Z","timestamp":1649920444000},"source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to\n                    <i>Mycobacterium marinum<\/i>\n                    granulomas in zebrafish"],"prefix":"10.1093","volume":"80","author":[{"given":"Julia Y","family":"Kam","sequence":"first","affiliation":[{"name":"Tuberculosis Research Program at the Centenary Institute, The University of Sydney, Camperdown, NSW 2050, 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M","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-672X","authenticated-orcid":false,"given":"Stefan H","family":"Oehlers","sequence":"additional","affiliation":[{"name":"Tuberculosis Research Program at the Centenary Institute, The University of Sydney, Camperdown, NSW 2050, Australia"},{"name":"The University of Sydney, Sydney Institute for Infectious Diseases, Camperdown, NSW 2050, Australia"},{"name":"A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science Technology and Research (A*STAR), Singapore, 138648, 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