{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:32:50Z","timestamp":1784233970800,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Council of Scientific and Industrial Research Emeritus Scheme","award":["21(1088)\/19\/EMR-II"],"award-info":[{"award-number":["21(1088)\/19\/EMR-II"]}]},{"name":"J.C. 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In our laboratory, the transcriptomes and miRnomes of AGS cells infected with H. pylori have been profiled, and an miRNA\u2013mRNA network has been constructed. MicroRNA 671-5p is upregulated during H. pylori infection of AGS cells or of mice. In this study, the role of miR-671-5p during infection has been investigated. It has been validated that miR-671-5p targets the transcriptional repressor CDCA7L, which is downregulated during infection (in vitro and in vivo) concomitant with miR-671-5p upregulation. Further, it has been established that the expression of monoamine oxidase A (MAO-A) is repressed by CDCA7L, and that MAO-A triggers the generation of reactive oxygen species (ROS). Consequently, miR-671-5p\/CDCA7L signaling is linked to the generation of ROS during H. pylori infection. Finally, it has been demonstrated that ROS-mediated caspase 3 activation and apoptosis that occurs during H. pylori infection, is dependent on the miR-671-5p\/CDCA7L\/MAO-A axis. Based on the above reports, it is suggested that targeting miR-671-5p could offer a means of regulating the course and consequences of H. pylori infection.<\/jats:p>","DOI":"10.1093\/femspd\/ftad006","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:14:28Z","timestamp":1682507668000},"source":"Crossref","is-referenced-by-count":3,"title":["Uncovering the role of microRNA671-5p\/CDCA7L\/monoamine oxidase-A signaling in <i>Helicobacter pylori<\/i> mediated apoptosis in gastric epithelial cells"],"prefix":"10.1093","volume":"81","author":[{"given":"Thurbu Tshering","family":"Lepcha","sequence":"first","affiliation":[{"name":"Department of Chemistry, Bose Institute , 93\/1 Acharya Prafulla Chandra Road Kolkata 700009 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , 93\/1 Acharya Prafulla Chandra Road Kolkata 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