{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:01:23Z","timestamp":1789084883417,"version":"build-2803163510"},"reference-count":161,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bacterial vaginosis, a type of vaginal inflammation, can be considered the main reason for abnormal discharges of the vagina and vaginal dysbiosis during reproductive years. Epidemiological investigations of females suffering from vaginitis demonstrated that at least 30% to 50% of all women had Bacterial vaginosis (BV). One of the fields of treatment is the use of probiotics, probiotics are commonly defined as viable microorganisms (yeasts or bacteria) that can positively affect the health of their hosts. They are used in foods, notably fermented milk products, and medicine-related products. The development of new probiotic strains is aimed at more active advantageous organisms. Lactobacillus species are the dominant bacteria in a normal vagina that can decrease the pH of the vagina by the production of lactic acid. A number of lactobacilli types can produce hydrogen peroxide as well. The presence of hydrogen peroxide-induced low pH can prevent the growth of several other microorganisms. The vaginal flora of BV cases can modify by replacing the Lactobacillus species with a high density of anaerobic bacteria (i.e. Mobiluncus sp. Bacteroides sp.), Mycoplasma hominis, and Gardnerella vaginalis. More vaginal infections are treated with medications, while there is a possibility of recurrence and chronic infection because of the adverse effects on the indigenous lactobacilli. Probiotics and prebiotics have shown capacities for optimizing, maintaining, and restoring the vaginal microflora. Therefore, biotherapeutics can offer alternative approaches to reduce infections of the vagina and thus promote consumers' health.<\/jats:p>","DOI":"10.1093\/femspd\/ftad012","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:11:46Z","timestamp":1686193906000},"source":"Crossref","is-referenced-by-count":22,"title":["Probiotics in vaginal health"],"prefix":"10.1093","volume":"81","author":[{"given":"Noushin","family":"Mashatan","sequence":"first","affiliation":[{"name":"Graduated, School of Applied Sciences, University of Brighton , Brighton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-9838","authenticated-orcid":false,"given":"Reza","family":"Heidari","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences , Shiraz 71348-14336 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Altafi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biological Science and Technology, Shiraz Pardis Branch, Islamic Azad University , Shiraz , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Amiri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences , Shiraz 71348-14336 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Ommati","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Environmental and Animal Products Safety, College of Animal Science and Technology , Luoyang, Henan , 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