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In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it can lead to Guillain\u2012Barr\u00e9 syndrome (GBS). Due to the lack of specific therapeutic methods against ZIKV, the development of a safe and effective vaccine is extremely important. Several potential ZIKV vaccines, such as live attenuated, inactivated, nucleic acid, viral vector, and recombinant subunit vaccines, have demonstrated promising outcomes in clinical trials involving human participants. Therefore, in this review, the recent developmental progress, advantages and disadvantages of these five vaccine types are examined, and practical recommendations for future development are provided.<\/jats:p>","DOI":"10.1093\/femspd\/ftad036","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T05:55:49Z","timestamp":1704779749000},"source":"Crossref","is-referenced-by-count":38,"title":["A review on Zika vaccine development"],"prefix":"10.1093","volume":"82","author":[{"given":"Zhe-Yu","family":"Peng","sequence":"first","affiliation":[{"name":"The Key Laboratory of Microbiology and Parasitology of Anhui Province, the Key Laboratory of Zoon-oses of High Institutions in Anhui, Department of Pathogen Biology, School of Basic Medical Sciences, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Agro-products Processing, Anhui Academy of Agricultural Sciences , Hefei 230031, Anhui, \u00a0","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zheng","family":"Lu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Microbiology and Parasitology of Anhui Province, the Key Laboratory of Zoon-oses of High Institutions in Anhui, Department of Pathogen Biology, School of Basic Medical Sciences, Anhui Medical University , Hefei 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Microbiology and Parasitology of Anhui Province, the Key Laboratory of Zoon-oses of High Institutions in Anhui, Department of Pathogen Biology, School of Basic Medical Sciences, Anhui Medical University , Hefei 230032 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