{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:23:22Z","timestamp":1789431802801,"version":"build-2803163510"},"reference-count":132,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003345","name":"CAMS","doi-asserted-by":"publisher","award":["2017-I2M-1-017"],"award-info":[{"award-number":["2017-I2M-1-017"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773338"],"award-info":[{"award-number":["81773338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nanjing Incubation Program for National Clinical Research Center","award":["2019060001"],"award-info":[{"award-number":["2019060001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida albicans (C. albicans) is a prevalent opportunistic pathogen that causes mucocutaneous and systemic infections, particularly in immunocompromised individuals. Macrophages play a crucial role in eliminating C. albicans in local and bloodstream contexts, while also regulating antifungal immune responses. However, C. albicans can induce macrophage lysis through pyroptosis, a type of regulated cell death. This process can enable C. albicans to escape from immune cells and trigger the release of IL-1\u03b2 and IL-18, which can impact both the host and the pathogen. Nevertheless, the mechanisms by which C. albicans triggers pyroptosis in macrophages and the key factors involved in this process remain unclear. In this review, we will explore various factors that may influence or trigger pyroptosis in macrophages induced by C. albicans, such as hypha, ergosterol, cell wall remodeling, and other virulence factors. We will also examine the possible immune response following macrophage pyroptosis.<\/jats:p>","DOI":"10.1093\/femspd\/ftae003","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T05:25:45Z","timestamp":1710825945000},"source":"Crossref","is-referenced-by-count":8,"title":["Macrophage pyroptosis induced by <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"82","author":[{"given":"Feng-yuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology,Chinese Academy of Medical Sciences & Peking Union Medical College , 12th. JiangWangmiao street, Nanjing, 210042 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Lian","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology,Chinese Academy of Medical Sciences & Peking Union Medical College , 12th. JiangWangmiao street, Nanjing, 210042 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-2326","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology,Chinese Academy of Medical Sciences & Peking Union Medical College , 12th. JiangWangmiao street, Nanjing, 210042 ,","place":["China"]},{"name":"Center for Global Health, School of Public Health, Nanjing Medical University , 101st. 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