{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:40:41Z","timestamp":1791852041032,"version":"4.3.4"},"reference-count":110,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":242,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI103197"],"award-info":[{"award-number":["AI103197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection (STI) in the USA. As an STI, C. trachomatis infections can cause inflammatory damage to the female reproductive tract and downstream sequelae including infertility. No vaccine currently exists to C. trachomatis, which evades sterilizing immune responses in its human host. A better understanding of this evasion will greatly benefit the production of anti-Chlamydia therapeutics and vaccination strategies. This minireview will discuss a single branch of the immune system, which activates in response to genital Chlamydia infection: so-called \u201ccell-autonomous immunity\u201d activated by the cytokine interferon-gamma. We will also discuss the mechanisms by which human and mouse-adapted Chlamydia species evade cell-autonomous immune responses in their native hosts. This minireview will examine five pathways of host defense and their evasion: (i) depletion of tryptophan and other nutrients, (ii) immunity-related GTPase-mediated defense, (iii) production of nitric oxide, (iv) IFN\u03b3-induced cell death, and (v) RNF213-mediated destruction of inclusions.<\/jats:p>","DOI":"10.1093\/femspd\/ftae019","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T03:43:36Z","timestamp":1724989416000},"source":"Crossref","is-referenced-by-count":10,"title":["Restriction and evasion: a review of IFN\u03b3-mediated cell-autonomous defense pathways during genital <i>Chlamydia<\/i> infection"],"prefix":"10.1093","volume":"82","author":[{"given":"Jeffrey R","family":"Reitano","sequence":"first","affiliation":[{"name":"Department of Integrative Immunobiology, Duke University Medical School , 207 Research Dr. Box 3010, Durham, NC 27710 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-4608","authenticated-orcid":false,"given":"J\u00f6rn","family":"Coers","sequence":"additional","affiliation":[{"name":"Department of Integrative Immunobiology, Duke University Medical School , 207 Research Dr. Box 3010, Durham, NC 27710 ,","place":["United States"]},{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical School , 213 Research Dr. Box 3054, Durham, NC 27710 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2024121400022887400_bib1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.micinf.2010.04.008","article-title":"Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome","volume":"12","author":"Abdul-Sater","year":"2010","journal-title":"Microbes 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