{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:06:57Z","timestamp":1789690017589,"version":"4.0.1"},"reference-count":84,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["KMU.AC.IR.400000652"],"award-info":[{"award-number":["KMU.AC.IR.400000652"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acinetobacter baumannii is a major cause of nosocomial infections globally. The increasing prevalence of multidrug-resistant (MDR) A. baumannii has become an important public health concern. To combat drug resistance, alternative methods such as phage therapy have been suggested. In total, 30 MDR A. baumannii strains were isolated from clinical specimens, and their antibiotic susceptibilities were determined. The Acinetobacter phage vB_AbaS_SA1, isolated from hospital sewage, was characterized. In addition to its plaque size, particle morphology, and host range, its genome sequence was determined and annotated. Finally, the antibacterial effects of phage alone, antibiotics alone, and phage\/antibiotic combinations were assessed against the A. baumannii strains. Phage vB_AbaS_SA1 had siphovirus morphology, showed a latent period of 20 min, and a 250 PFU\/cell (plaque forming unit\/cell) burst size. When combined with antibiotics, vB_AbaS_SA1 (SA1) showed a significant phage-antibiotic synergy effect and reduced the overall effective concentration of antibiotics in time-kill assessments. The genome of SA1 is a linear double-stranded DNA of 50\u2009108\u00a0bp in size with a guanine-cytosine (GC) content of 39.15%. Despite the potent antibacterial effect of SA1, it is necessary to perform additional research to completely elucidate the mechanisms of action and potential constraints associated with utilizing this bacteriophage.<\/jats:p>","DOI":"10.1093\/femspd\/ftae028","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T09:57:07Z","timestamp":1729591027000},"source":"Crossref","is-referenced-by-count":22,"title":["Characterization of bacteriophage vB_AbaS_SA1 and its synergistic effects with antibiotics against clinical multidrug-resistant <i>Acinetobacter baumannii<\/i> isolates"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-0092","authenticated-orcid":false,"given":"Sanaz","family":"Rastegar","sequence":"first","affiliation":[{"name":"Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]},{"name":"Department of Medical Microbiology (Bacteriology and Virology), Afzalipour School of Medicine , Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salehe","family":"Sabouri","sequence":"additional","affiliation":[{"name":"Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]},{"name":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Tadjrobehkar","sequence":"additional","affiliation":[{"name":"Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]},{"name":"Department of Medical Microbiology (Bacteriology and Virology), Afzalipour School of Medicine , Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Samareh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Niaz","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Human Microbiome Research Program, Faculty of Medicine, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafise","family":"Sanjari","sequence":"additional","affiliation":[{"name":"Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hosseini-Nave","sequence":"additional","affiliation":[{"name":"Medical Mycology and Bacteriology 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