{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:58:22Z","timestamp":1753876702451,"version":"3.41.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":346,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15AI174169-01A1"],"award-info":[{"award-number":["1R15AI174169-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield State University","award":["P20GM103434"],"award-info":[{"award-number":["P20GM103434"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chlamydia genital infection caused by Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. A mouse model has been developed in our laboratory to better understand the effect of cold-induced stress on chlamydia genital infection and immune response. However, the stress mechanism affecting the host response to Chlamydia muridarum genital infection remains unclear. Here, we demonstrate a role for the beta2-adrenergic receptor (\u03b22-AR), which binds noradrenaline and modulates the immune response against chlamydia genital infection in a mouse model. A successful \u03b22-AR homozygous knockout (KO) mouse model was used to study the infection and analyze the immune response. Our data show that stressed mice lacking the \u03b22-AR are less susceptible to C. muridarum genital infection than controls. A correlation was obtained between lower organ load and higher interferon-gamma production by CD4+\u00a0and CD8+\u00a0cells of the KO mice. Furthermore, exposure of CD4+\u00a0T cells to noradrenaline alters the production of cytokines in mice during C. muridarum genital infection. This study suggests that the blockade of \u03b22-AR signaling could be used to increase resistance to chlamydia genital infection. We value the \u03b22-AR KO as a viable model that can provide reproducible results in investigating medical research, including chlamydia genital infection.<\/jats:p>","DOI":"10.1093\/femspd\/ftae029","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T03:56:13Z","timestamp":1733975773000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterization of beta2-adrenergic receptor knockout mouse model during <i>Chlamydia muridarum<\/i> genital infection"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9055-3749","authenticated-orcid":false,"given":"Tesfaye","family":"Belay","sequence":"first","affiliation":[{"name":"Department of Applied Sciences and Mathematics, College of STEM, Bluefield State University , Bluefield, WV 24701 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-2946","authenticated-orcid":false,"given":"Rajnish","family":"Sahu","sequence":"additional","affiliation":[{"name":"Center for NanoBiotechnology Research, Department of Biological Sciences, Alabama State University , 1627 Harris Way, Montgomery, AL 36104 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vida","family":"Dennis","sequence":"additional","affiliation":[{"name":"Center for NanoBiotechnology Research, Department of Biological Sciences, Alabama State University , 1627 Harris Way, Montgomery, AL 36104 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences and Mathematics, College of STEM, Bluefield State University , Bluefield, WV 24701 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences and Mathematics, College of STEM, Bluefield State University , Bluefield, WV 24701 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences and Mathematics, College of STEM, Bluefield State University , Bluefield, WV 24701 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlei","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences and Mathematics, College of STEM, Bluefield State University , Bluefield, WV 24701 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathasha","family":"Woart","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences and Mathematics, College of STEM, Bluefield State University , Bluefield, WV 24701 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"2024121400034344600_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1037\/0003-066X.49.1.15","article-title":"Socioeconomic status and health. 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