{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:01:48Z","timestamp":1764061308866,"version":"3.41.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004725","name":"Ministry of Economic Affairs","doi-asserted-by":"publisher","award":["LSHM20085"],"award-info":[{"award-number":["LSHM20085"]}],"id":[{"id":"10.13039\/501100004725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inflammatory diseases of the human gastrointestinal tract are affected by the microbes that reside in the mucosal surfaces. Patients with inflammatory bowel diseases (IBD) have altered bacterial and fungal intestinal compositions, including higher levels of fecal Candida yeasts. Ongoing research indicates that genetic and phenotypic diversity of Candida albicans may be linked with disease severity. Here, we set out to investigate feces-derived C. albicans strains from individuals with IBD and healthy volunteers through microsatellite-based genotyping and phenotypic assays. A seven-locus microsatellite panel was applied, of which six loci were newly developed. It appears that there is no specific lineage of C. albicans that is associated with IBD, but rather that the three study populations (Crohn's disease, ulcerative colitis, healthy volunteers) do have distinguishable distributions of genotypes. In addition, phenotypic characterization by means of enzyme release assays revealed trends between genotypes, virulence-related enzyme activity, and clinical biomarkers. We thus show that microsatellite typing can describe genetic diversity of feces-derived C. albicans strains, and that phenotypic diversity of these strains may indeed correlate with fungal genotype or disease. This study opens further possibilities to investigate fecal fungi in relation to severity of inflammation in IBD or in other (intestinal) diseases.<\/jats:p>","DOI":"10.1093\/femspd\/ftaf001","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T03:27:42Z","timestamp":1736566062000},"source":"Crossref","is-referenced-by-count":1,"title":["Typing of feces-derived <i>Candida albicans<\/i> strains using a novel seven-locus microsatellite panel reveals associations with yeast phenotype in individuals with inflammatory bowel disease"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-9048","authenticated-orcid":false,"given":"Isabelle A M","family":"van\u00a0Thiel","sequence":"first","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Royal Dutch Academy of Arts and Sciences, Uppsalalaan 8 , 3584 CT Utrecht ,","place":["The Netherlands"]},{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Meibergdreef 69-71 , 1105 BK Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam , Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, 1105 AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-8055","authenticated-orcid":false,"given":"Irini A M","family":"Kreulen","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Meibergdreef 69-71 , 1105 BK Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam , Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, 1105 AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-044X","authenticated-orcid":false,"given":"M\u00e8lanie V","family":"B\u00e9nard","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam , Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, 1105 AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC). Meibergdreef 9 , 1105 AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-1852","authenticated-orcid":false,"given":"Marcus C","family":"de\u00a0Goffau","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Meibergdreef 69-71 , 1105 BK Amsterdam ,","place":["The Netherlands"]},{"name":"Wellcome Sanger Institute , Hinxton, Saffron Walden CB10 1RQ ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-2058","authenticated-orcid":false,"given":"Bart","family":"Theelen","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Royal Dutch Academy of Arts and Sciences, Uppsalalaan 8 , 3584 CT Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0971-8599","authenticated-orcid":false,"given":"Sigrid E M","family":"Heinsbroek","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Meibergdreef 69-71 , 1105 BK Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam , Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, 1105 AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC). Meibergdreef 9 , 1105 AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja K","family":"Zylka","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Royal Dutch Academy of Arts and Sciences, Uppsalalaan 8 , 3584 CT Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-0453","authenticated-orcid":false,"given":"Cyriel Y","family":"Ponsioen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC). Meibergdreef 9 , 1105 AZ Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-3609","authenticated-orcid":false,"given":"Teun","family":"Boekhout","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Royal Dutch Academy of Arts and Sciences, Uppsalalaan 8 , 3584 CT Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-1547","authenticated-orcid":false,"given":"Wouter J","family":"de\u00a0Jonge","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Meibergdreef 69-71 , 1105 BK Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam , Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, 1105 AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC). Meibergdreef 9 , 1105 AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, Venusberg-Campus 1 , 53127 Bonn ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-6585","authenticated-orcid":false,"given":"S\u00f8ren","family":"Rosendahl","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Copenhagen , Universitetsparken 15, DK-2100 Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-356X","authenticated-orcid":false,"given":"Ren\u00e9 M","family":"van\u00a0den\u00a0Wijngaard","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center (AMC), Meibergdreef 69-71 , 1105 BK Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC, University of Amsterdam , Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, 1105 AZ Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Location Academic Medical Center (AMC). 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