{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:50:31Z","timestamp":1789390231037,"version":"build-2803163510"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG SCHU 2394\/3-1"],"award-info":[{"award-number":["DFG SCHU 2394\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,31]]},"DOI":"10.1093\/femspd\/ftx038","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T11:31:13Z","timestamp":1490787073000},"source":"Crossref","is-referenced-by-count":12,"title":["Comparison of the inflammatory response of brain microvascular and peripheral endothelial cells following infection with Neisseria meningitidis"],"prefix":"10.1093","volume":"75","author":[{"given":"Julia","family":"Dick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Hebling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Becam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamed-Kheir","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Schubert-Unkmeir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,1]]},"reference":[{"key":"key\n\t\t\t\t20170622025532_bib1","first-page":"97","article-title":"Interleukin-8 and related chemotactic cytokines\u2013CXC and CC chemokines","volume":"55","year":"1994","journal-title":"Adv Immunol"},{"key":"key\n\t\t\t\t20170622025532_bib2","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.pgen.0030023","article-title":"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18","volume":"3","year":"2007","journal-title":"PLos Genet"},{"key":"key\n\t\t\t\t20170622025532_bib3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm.3563","article-title":"Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization","volume":"20","year":"2014","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170622025532_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1012259529167","article-title":"Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research","volume":"4","year":"2001","journal-title":"Angiogenesis"},{"key":"key\n\t\t\t\t20170622025532_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1574-6976.2006.00056.x","article-title":"Multilocus sequence typing for global surveillance of meningococcal disease","volume":"31","year":"2007","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20170622025532_bib6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1473-3099(11)70027-5","article-title":"From tailor-made to ready-to-wear meningococcal B vaccines: longitudinal study of a clonal meningococcal B outbreak","volume":"11","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20170622025532_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1365-2958.2000.01694.x","article-title":"Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein","volume":"35","year":"2000","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib8","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1128\/IAI.70.8.4035-4044.2002","article-title":"Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines","volume":"70","year":"2002","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib9","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2010.11.035","article-title":"Meningococcus hijacks a \u03b22-adrenoceptor\/\u03b2-Arrestin pathway to cross brain microvasculature endothelium","volume":"143","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170622025532_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1086\/653583","article-title":"Emergence of new virulent Neisseria meningitidis serogroup C sequence type 11 isolates in France","volume":"202","year":"2010","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170622025532_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","year":"2009","journal-title":"J Interf Cytok Res"},{"key":"key\n\t\t\t\t20170622025532_bib12","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1128\/IAI.69.7.4351-4357.2001","article-title":"Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria","volume":"69","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib13","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/BF02623694","article-title":"Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926","volume":"26","year":"1990","journal-title":"In Vitro Cell Dev B"},{"key":"key\n\t\t\t\t20170622025532_bib14","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1073\/pnas.80.12.3734","article-title":"Permanent cell line expressing human factor VIII-related antigen established by hybridization","volume":"80","year":"1983","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170622025532_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/cyto.1999.0521","article-title":"Production of cytokines by monocytes, epithelial and endothelial cells activated by Streptococcus bovis","volume":"12","year":"2000","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20170622025532_bib16","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1128\/IAI.00644-06","article-title":"Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis","volume":"74","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1099\/0022-1317-50-10-847","article-title":"Cytokines, chemokines and other effector molecules involved in meningococcal disease","volume":"50","year":"2001","journal-title":"J Med Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/infdis\/167.2.471","article-title":"Interleukin-8 in serum and cerebrospinal fluid from patients with meningococcal disease","volume":"167","year":"1993","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170622025532_bib19","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/SHK.0000000000000441","article-title":"Massive organ inflammation in experimental and in clinical meningococcal septic shock","volume":"44","year":"2015","journal-title":"Shock"},{"key":"key\n\t\t\t\t20170622025532_bib20","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3390\/biology2031054","article-title":"The biology of Neisseria adhesins","volume":"2","year":"2013","journal-title":"Biology"},{"key":"key\n\t\t\t\t20170622025532_bib21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0140-6736(91)91297-8","article-title":"Point mutation in meningococcal por A gene associated with increased endemic disease","volume":"337","year":"1991","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170622025532_bib22","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1128\/IAI.00601-07","article-title":"Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression","volume":"75","year":"2007","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1086\/427514","article-title":"Chemokine patterns in meningococcal disease","volume":"191","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170622025532_bib24","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2958.1993.tb01615.x","article-title":"Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells","volume":"8","year":"1993","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.186.2.247","article-title":"Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines","volume":"186","year":"1997","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170622025532_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0006-291X(90)91929-M","article-title":"NAP-1\/IL-8 induces up-regulation of CR1 receptors in human neutrophil leukocytes","volume":"166","year":"1990","journal-title":"Biochem Bioph Res Co"},{"key":"key\n\t\t\t\t20170622025532_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/S1679-45082015RB3438","article-title":"Chemokines and immunity","volume":"13","year":"2015","journal-title":"Einstein (S\u00e3o Paulo, Brazil)"},{"key":"key\n\t\t\t\t20170622025532_bib28","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200105033441807","article-title":"Meningococcal disease","volume":"344","year":"2001","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170622025532_bib29","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/gb-2009-10-10-r110","article-title":"NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis","volume":"10","year":"2009","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20170622025532_bib30","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170622025532_bib31","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/IAI.01508-06","article-title":"Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis","volume":"75","year":"2007","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1365-2249.2002.01768.x","article-title":"CD14-dependent and -independent cytokine and chemokine production by human THP-1 monocytes stimulated by Streptococcus suis capsular type 2","volume":"127","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20170622025532_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1574-695X.2006.00067.x","article-title":"Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system","volume":"47","year":"2006","journal-title":"FEMS Immunol Med Mic"},{"key":"key\n\t\t\t\t20170622025532_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1189\/jlb.70.2.283","article-title":"Contributions of Neisseria meningitidis LPS and non-LPS to proinflammatory cytokine response","volume":"70","year":"2001","journal-title":"J Leukocyte Biol"},{"key":"key\n\t\t\t\t20170622025532_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-5728(97)00036-2","article-title":"Selective expression of adhesion molecules on human brain microvascular endothelial cells","volume":"76","year":"1997","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20170622025532_bib36","doi-asserted-by":"crossref","first-page":"21\u2013","DOI":"10.1006\/cyto.1999.0506","article-title":"Neisseria meningitidis induces the expression of the TNF-alpha gene in endothelial cells","volume":"12","year":"2000","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20170622025532_bib37","doi-asserted-by":"crossref","first-page":"e0154047","DOI":"10.1371\/journal.pone.0154047","article-title":"Evolutionary events associated with an outbreak of meningococcal disease in men who have sex with men","volume":"11","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170622025532_bib38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/infdis\/151.3.535","article-title":"The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis","volume":"151","year":"1985","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170622025532_bib39","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1046\/j.1365-2958.2002.03222.x","article-title":"Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells","volume":"46","year":"2002","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.2003.tb00648.x","article-title":"Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2","volume":"35","year":"2003","journal-title":"FEMS Immunol Med Mic"},{"key":"key\n\t\t\t\t20170622025532_bib42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/infdis\/172.2.433","article-title":"Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections","volume":"172","year":"1995","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170622025532_bib43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2958.1993.tb00922.x","article-title":"Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cells","volume":"10","year":"1993","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib44","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2958.1993.tb00972.x","article-title":"Pilus-facilitated adherence of Neisseria meningitidis to human epithelial and endothelial cells: modulation of adherence phenotype occurs concurrently with changes in primary amino acid sequence and the glycosylation status of pilin","volume":"10","year":"1993","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib45","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1128\/JCM.36.9.2465-2470.1998","article-title":"Necessity of molecular techniques to distinguish between Neisseria meningitidis strains isolated from patients with meningococcal disease and from their healthy contacts","volume":"36","year":"1998","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170622025532_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1084\/jem.169.1.333","article-title":"The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome","volume":"169","year":"1989","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170622025532_bib47","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1128\/IAI.69.4.2718-2722.2001","article-title":"Differential gene expression during meningeal-meningococcal interaction: evidence for self-defense and early release of cytokines and chemokines","volume":"69","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib48","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1128\/IAI.00655-06","article-title":"Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice","volume":"74","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170622025532_bib49","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of monocytes and dendritic cells in blood","volume":"116","year":"2010","journal-title":"Blood"}],"container-title":["Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/75\/5\/ftx038\/17829665\/ftx038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:23:56Z","timestamp":1692743036000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article-lookup\/doi\/10.1093\/femspd\/ftx038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,1]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,4,1]]},"published-print":{"date-parts":[[2017,7,31]]}},"URL":"https:\/\/doi.org\/10.1093\/femspd\/ftx038","relation":{},"ISSN":["2049-632X"],"issn-type":[{"value":"2049-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,1]]}}}