{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:53:53Z","timestamp":1790614433276,"version":"4.1.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100007197","name":"US Public Health Service","doi-asserted-by":"publisher","award":["AI-49193"],"award-info":[{"award-number":["AI-49193"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1093\/femspd\/ftx126","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T20:14:55Z","timestamp":1514405695000},"source":"Crossref","is-referenced-by-count":35,"title":["Multiple intraintestinal signals coordinate the regulation of Vibrio cholerae virulence determinants"],"prefix":"10.1093","volume":"76","author":[{"given":"Kenneth M","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S","family":"Gellings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"key\n\t\t\t\t20180131114658_bib1","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/IAI.00409-09","article-title":"Bicarbonate induces Vibrio cholerae virulence gene expression by enhancing ToxT activity","volume":"77","author":"Abuaita","year":"2009","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib2","doi-asserted-by":"crossref","first-page":"e0003832","DOI":"10.1371\/journal.pntd.0003832","article-title":"Updated global burden of cholera in endemic countries","volume":"9","author":"Ali","year":"2015","journal-title":"PLoS Neglect Trop D"},{"key":"key\n\t\t\t\t20180131114658_bib3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/mmi.13170","article-title":"Role of ToxS in the proteolytic cascade of virulence regulator ToxR in Vibrio cholerae","volume":"98","author":"Almagro","year":"2015","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib4","doi-asserted-by":"crossref","first-page":"e00403","DOI":"10.1128\/mBio.00403-13","article-title":"Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae","volume":"4","author":"Anthouard","year":"2013","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180131114658_bib5","doi-asserted-by":"crossref","first-page":"e0004031","DOI":"10.1371\/journal.pntd.0004031","article-title":"Bile salts modulate the mucin-activated type VI secretion system of pandemic Vibrio cholerae","volume":"9","author":"Bachmann","year":"2015","journal-title":"PLoS Neglect Trop D"},{"key":"key\n\t\t\t\t20180131114658_bib6","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0016-5085(96)70024-0","article-title":"7 alpha-dehydroxylating bacteria enchance deoxcholic acid input and cholesterol saturation of bile in patients with gallstones","volume":"111","author":"Berr","year":"1996","journal-title":"Gatroenterology"},{"key":"key\n\t\t\t\t20180131114658_bib7","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1128\/IAI.69.7.4681-4685.2001","article-title":"Vibrio cholerae tolC is required for bile resistance and colonization","volume":"69","author":"Bina","year":"2001","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib8","doi-asserted-by":"crossref","first-page":"e00366","DOI":"10.1128\/mBio.00366-13","article-title":"Vibrio cholerae ToxR downregulates virulence factor production in response to Cyclo(Phe-Pro)","volume":"4","author":"Bina","year":"2013","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180131114658_bib9","doi-asserted-by":"crossref","first-page":"e02151","DOI":"10.7554\/eLife.02151","article-title":"Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling","volume":"3","author":"Briegel","year":"2014","journal-title":"eLife"},{"key":"key\n\t\t\t\t20180131114658_bib10","doi-asserted-by":"crossref","first-page":"10412","DOI":"10.1073\/pnas.1604693113","article-title":"Chemotaxis cluster 1 proteins form cytoplasmic arrays in Vibrio cholerae and are stabilized by a double signaling domain receptor DosM","volume":"113","author":"Briegel","year":"2016","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2958.1995.tb02408.x","article-title":"Organization of tcp, acf and toxT genes within a ToxT-dependent operon","volume":"16","author":"Brown","year":"1995","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib12","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1073\/pnas.0308052101","article-title":"Both chemotaxis and net motility greatly influence the i nfectivity of Vibrio cholerae","volume":"101","author":"Butler","year":"2004","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrmicro1207","article-title":"Going against the grain; chemotaxis and infection in Vibrio cholerae","volume":"3","author":"Butler","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.femsle.2004.08.039","article-title":"Chemotaxis in Vibrio cholerae","volume":"239","author":"Boin","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"key\n\t\t\t\t20180131114658_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1574-6968.2009.01835.x","article-title":"The ToxT-dependent methyl-accepting chemoreceptors AcfB and TcpI contribute to Vibrio cholerae intestinal colonization","volume":"301","author":"Chapparro","year":"2010","journal-title":"FEMS Microbiol Lett"},{"key":"key\n\t\t\t\t20180131114658_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1365-2958.1997.2191585.x","article-title":"A branch of the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains","volume":"23","author":"Champion","year":"1997","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib17","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1128\/JB.186.20.6809-6814.2004","article-title":"Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae","volume":"186","author":"Chatterjee","year":"2004","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180131114658_bib18","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/IAI.01435-06","article-title":"Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae","volume":"75","author":"Chatterjee","year":"2007","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib19","doi-asserted-by":"crossref","first-page":"28644","DOI":"10.1074\/jbc.M111.258780","article-title":"N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids","volume":"286","author":"Childers","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180131114658_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2217\/17460913.2.3.335","article-title":"Regulation of virulence in Vibrio cholerae; the ToxR regulon","volume":"2","author":"Childers","year":"2007","journal-title":"Future Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib21","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0140-6736(17)30559-7","article-title":"Cholera","volume":"23","author":"Clemens","year":"2017","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180131114658_bib22","first-page":"261","article-title":"ADP-ribosylating exotoxins","volume-title":"Multifunctional Proteins","author":"Collier","year":"1980"},{"key":"key\n\t\t\t\t20180131114658_bib23","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1126\/science.274.5295.2025","article-title":"Global climate and infectious disease; the cholera paradigm","volume":"274","author":"Colwell","year":"1996","journal-title":"Science"},{"key":"key\n\t\t\t\t20180131114658_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2958.1998.00925.x","article-title":"Analysis of ToxR-dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae","volume":"29","author":"Crawford","year":"1998","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib25","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1073\/pnas.88.12.5403","article-title":"Regulatory cascade controls virulence in Vibrio cholerae","volume":"88","author":"DiRita","year":"1991","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib26","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1128\/IAI.62.8.3289-3298.1994","article-title":"The Vibrio cholerae acfB colonization determinant encodes an inner membrane protein that is related to a family of signal-transducing proteins","volume":"62","author":"Everiss","year":"1994","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.cellbio.13.1.457","article-title":"The two-component signaling pathway of bacterial chemotaxis: A molecular view of signal transduction by receptors, kinases, and adaptation enzymes","volume":"13","author":"Falke","year":"1997","journal-title":"Annu Rev Cell Dev Bi"},{"key":"key\n\t\t\t\t20180131114658_bib28","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1128\/IAI.01377-13","article-title":"Enhanced interaction of Vibrio cholerae virulence regulators TcpP and ToxR under oxygen-limiting conditions","volume":"82","author":"Fan","year":"2014","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1128\/IAI.34.1.234-240.1981","article-title":"Role of chemotaxis in the association of motile bacteria with intestinal mucosa: in vitro studies","volume":"34","author":"Freter","year":"1981","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0076-6879(94)35167-8","article-title":"Regulation of cholera toxin by temperature, pH and osmolarity","volume":"235","author":"Gardel","year":"1994","journal-title":"Methods Enzymol"},{"key":"key\n\t\t\t\t20180131114658_bib31","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1128\/IAI.64.6.2246-2255.1996","article-title":"Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression","volume":"64","author":"Gardel","year":"1996","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib32","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1073\/pnas.75.7.3050","article-title":"ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase","volume":"75","author":"Gill","year":"1978","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1128\/IAI.65.3.1131-1134.1997","article-title":"Bile affects production of virulence factors and motility of Vibrio cholerae","volume":"65","author":"Gupta","year":"1997","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib34","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1128\/IAI.62.7.2669-2678.1994","article-title":"The Vibrio cholerae toxin-coregulated-pilus gene tcpI encodes a homolog of methyl-accepting chemotaxis proteins","volume":"62","author":"Harkey","year":"1994","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib35","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/S0140-6736(12)60436-X","article-title":"Cholera","volume":"379","author":"Harris","year":"2012","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180131114658_bib36","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1073\/pnas.95.2.730","article-title":"TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae","volume":"95","author":"Hase","year":"1998","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib37","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1073\/pnas.96.6.3183","article-title":"Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae","volume":"96","author":"H\u00e4se","year":"1999","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib38","first-page":"707","article-title":"Calcium enhances bile salt-dependent virulence activation in Vibrio cholerae","volume":"85","author":"Hay","year":"2016","journal-title":"Infec Immun"},{"key":"key\n\t\t\t\t20180131114658_bib39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/IAI.02617-14","article-title":"Host intestinal signal-promoted biofilm dispersal induces Vibrio cholerae colonization","volume":"83","author":"Hay","year":"2015","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib40","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0959-440X(92)90079-M","article-title":"Bacterial chemoreceptors","volume":"2","author":"Hazelbauer","year":"1992","journal-title":"Curr Opin Struc Biol"},{"key":"key\n\t\t\t\t20180131114658_bib41","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/35020000","article-title":"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae","volume":"406","author":"Heidelberg","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180131114658_bib42","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1128\/jb.174.21.6974-6980.1992","article-title":"The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activators","volume":"174","author":"Higgens","year":"1992","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180131114658_bib43","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/mmi.12887","article-title":"Hypoxia-induced localization of chemotaxis-related signaling proteins in Vibrio cholerae","volume":"95","author":"Hiremath","year":"2014","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2036.1994.tb00319.x","article-title":"Gastroduodenal bicarbonate secretion","volume":"8","author":"Hogan","year":"1994","journal-title":"Aliment Pharmocol Ther"},{"key":"key\n\t\t\t\t20180131114658_bib45","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1073\/pnas.0409559102","article-title":"Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner","volume":"102","author":"Hung","year":"2005","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib46","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1116739","article-title":"Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization","volume":"310","author":"Hung","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20180131114658_bib47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2958.2005.04846.x","article-title":"Bile acids stimulate biofilm formation in Vibrio cholerae","volume":"59","author":"Hung","year":"2006","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/JCM.22.3.405-408.1985","article-title":"New medium for the production of cholera toxin by Vibrio cholerae 01 biotype El Tor","volume":"22","author":"Iwanaga","year":"1985","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib49","doi-asserted-by":"crossref","first-page":"e1004837","DOI":"10.1371\/journal.ppat.1004837","article-title":"Quadruple quorum sensing imputs control Vibrio cholerae virulence and maintain system robustness","volume":"11","author":"Jung","year":"2015","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180131114658_bib50","doi-asserted-by":"crossref","first-page":"e1005570","DOI":"10.1371\/journal.ppat.1005570","article-title":"ToxR antagonizes H-NS regulation of horizontally acquired genes to drive host colonization","volume":"12","author":"Kazi","year":"2016","journal-title":"PLOS Pathog"},{"key":"key\n\t\t\t\t20180131114658_bib51","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1128\/IAI.01664-14","article-title":"Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae","volume":"82","author":"Koestler","year":"2014","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib52","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4161\/19490976.2014.985989","article-title":"Intestinal GPS; bile and bicarbonate control cyclic di-GMP to provide Vibrio cholerae with spatial cues within the small intestine","volume":"5","author":"Koestler","year":"2014","journal-title":"Gut Microbes"},{"key":"key\n\t\t\t\t20180131114658_bib53","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1128\/IAI.72.7.3961-3967.2004","article-title":"Effect of anaerobiosis on expression of virulence factors in Vibrio cholerae","volume":"72","author":"Krishnan","year":"2004","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib54","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1073\/pnas.111581598","article-title":"Selection for in vivo regulators of bacterial virulence","volume":"98","author":"Lee","year":"2001","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(00)81551-2","article-title":"Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection","volume":"99","author":"Lee","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180131114658_bib56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2958.2000.01699.x","article-title":"Molecular cloning and transcriptional regulation of ompT, a ToxR-repressed gene in Vibrio cholerae","volume":"35","author":"Li","year":"2000","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib57","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1073\/pnas.1014640108","article-title":"Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB","volume":"108","author":"Liu","year":"2011","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2015.12.038","article-title":"Differential thiol-based switches jumpstart Vibrio cholerae pathogenesis","volume":"14","author":"Liu","year":"2016","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180131114658_bib59","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1073\/pnas.0915021107","article-title":"Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes","volume":"107","author":"Lowden","year":"2010","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib60","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1995-7645(11)60149-1","article-title":"Cholera: a great global concern","volume":"4","author":"Mandal","year":"2011","journal-title":"Asian Pac J Trop Med"},{"key":"key\n\t\t\t\t20180131114658_bib61","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.resmic.2008.10.005","article-title":"Anaerobic growth promotes synthesis of colonization factors encoded at the Vibrio pathogenicity island in Vibrio cholerae El Tor","volume":"160","author":"Marrero","year":"2009","journal-title":"Res Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib62","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1128\/IAI.01094-07","article-title":"Regulatory networks controlling Vibrio cholerae virulence gene expression","volume":"75","author":"Matson","year":"2007","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib63","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2741\/4154","article-title":"Cell biology of bacterial sensory modules","volume":"18","author":"Mauriello","year":"2013","journal-title":"Front Biocsi"},{"key":"key\n\t\t\t\t20180131114658_bib64","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1073\/pnas.81.11.3471","article-title":"Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR","volume":"81","author":"Miller","year":"1987","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib65","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(87)90430-2","article-title":"Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein","volume":"48","author":"Miller","year":"1987","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180131114658_bib66","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/jb.170.6.2575-2583.1988","article-title":"A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR","volume":"170","author":"Miller","year":"1988","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180131114658_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1004405","article-title":"Insights into Vibr;io cholerae intestinal colonization from monitoring fluorescently labeled bacteria","volume":"10","author":"Millet","year":"2014","journal-title":"PLOS Pathog"},{"key":"key\n\t\t\t\t20180131114658_bib68","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrmicro2204","article-title":"Cholera transmission; the host, pathogen and bacteriophage dynamic","volume":"7","author":"Nelson","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib69","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/IAI.00039-12","article-title":"Mlp24 (McpX) of Vibrio cholerae implicated in pathogenicity functions as a chemoreceptor for multiple amino acids","volume":"80","author":"Nishiyama","year":"2012","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib70","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2165\/00003495-198631050-00003","article-title":"The effect of drugs on bile-flow and composition-an overview","volume":"31","author":"Okolicsanyi","year":"1986","journal-title":"Drugs"},{"key":"key\n\t\t\t\t20180131114658_bib71","first-page":"228","article-title":"Vibrio species","volume-title":"Food Microbiology: Fundamentals and Frontiers","author":"Oliver","year":"1997"},{"key":"key\n\t\t\t\t20180131114658_bib72","first-page":"29","article-title":"Expression of Vibrio cholerae virulence genes in response to environmental signals","volume":"3","author":"Peterson","year":"2002","journal-title":"Curr Issues Intest Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib73","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1128\/IAI.56.11.2822-2829.1988","article-title":"Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization","volume":"56","author":"Peterson","year":"1988","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib74","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1128\/JB.02409-14","article-title":"Mechanism for inhibition of Vibrio cholerae ToxT activity by the unsaturated fatty acid components of bile","volume":"197","author":"Plecha","year":"2015","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180131114658_bib75","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1365-2958.2005.04897.x","article-title":"Characterization of functional domains of the Vibrio cholerae virulence regulatory ToxT","volume":"58","author":"Prouty","year":"2005","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib76","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.1073\/pnas.170219997","article-title":"Altered expression of the ToxR-regulated porins OmpU and OmpT diminishes Vibrio cholerae bile resistance virulence factor expression, and intestinal colonization","volume":"97","author":"Provenzano","year":"2000","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib77","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1128\/IAI.68.3.1491-1497.2000","article-title":"The virulence regulatory protein ToxR mediates enhanced bile resistance in Vibrio cholerae and other pathogenic Vibrio species","volume":"68","author":"Provenzano","year":"2000","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180131114658_bib79","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4161\/gmic.26944","article-title":"Efficient responses to host and bacterial signals during Vibrio cholerae colonization","volume":"5","author":"Rothenbacher","year":"2014","journal-title":"Gut Microbes"},{"key":"key\n\t\t\t\t20180131114658_bib80","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/gad.2015011","article-title":"AphA and LuxR\/HapR reciprocally control quorum sensing in vibrios","volume":"25","author":"Rutherford","year":"2011","journal-title":"Gene Dev"},{"key":"key\n\t\t\t\t20180131114658_bib81","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0140-6736(03)15328-7","article-title":"Cholera","volume":"363","author":"Sack","year":"2004","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180131114658_bib82","doi-asserted-by":"crossref","first-page":"e0149603","DOI":"10.1371\/journal.pone.0149603","article-title":"Biofilm formation and detachment in gram-negative pathoges is modulated by select bile acids","volume":"11","author":"Sanchez","year":"2016","journal-title":"PLOS One"},{"key":"key\n\t\t\t\t20180131114658_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15226\/sojmid\/3\/3\/00141","article-title":"The Vibrio cholerae ToxR regulon encodes host-specfic chemotaxis proteins that function in intestinal colonization","volume":"3","author":"Selvaraj","year":"2015","journal-title":"SOJ Microbiol Infec Dis"},{"key":"key\n\t\t\t\t20180131114658_bib84","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13099-014-0038-9","article-title":"Fine tuning of virulence regulatory pathways in enteric bacteria in response to varying bile and oxygen concentrations in the gastrointestinal tract","volume":"6","author":"Sengupta","year":"2014","journal-title":"Gut Pathog"},{"key":"key\n\t\t\t\t20180131114658_bib85","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1073\/pnas.0611643104","article-title":"Virstatin inhibits dimerization of the transcriptional activator ToxT","volume":"104","author":"Shakhnovich","year":"2007","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180131114658_bib86","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2958.1997.5481909.x","article-title":"Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuli","volume":"25","author":"Skorupski","year":"1997","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180131114658_bib87","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1038\/emboj.2010.178","article-title":"Spatial organization in bacterial chemotaxis","volume":"29","author":"Sourjik","year":"2010","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20180131114658_bib88","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ceb.2011.11.008","article-title":"Responding to chemical gradients: bacterial chemotaxis","volume":"24","author":"Sourjik","year":"2012","journal-title":"Cur Opin Cell Biol"},{"key":"key\n\t\t\t\t20180131114658_bib89","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1128\/MMBR.00029-12","article-title":"Ecology and physics of bacterial chemotaxis in the ocean","volume":"75","author":"Stocker","year":"2012","journal-title":"Microbiol Mol Biol R"},{"key":"key\n\t\t\t\t20180131114658_bib90","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1128\/JB.01824-14","article-title":"Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters","volume":"196","author":"Thomson","year":"2014","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180131114658_bib91","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/IAI.73.9.5873-5882.2005","article-title":"Cyclic diguanylate regulates Vibrio cholerae virulence gene expression","volume":"73","author":"Tischler","year":"2005","journal-title":"Infec Immun"},{"key":"key\n\t\t\t\t20180131114658_bib92","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nrm1524","article-title":"Making sense of it all: bacterial chemotaxis","volume":"12","author":"Wadhams","year":"2004","journal-title":"Nat Rev Mol Cell Bio"},{"key":"key\n\t\t\t\t20180131114658_bib93","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1073\/pnas.1218039110","article-title":"Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence","volume":"110","author":"Yang","year":"2013","journal-title":"P Natl Acad Sci USA"}],"container-title":["Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femspd\/article-pdf\/76\/1\/ftx126\/23730408\/ftx126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T23:43:41Z","timestamp":1603583021000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femspd\/article\/doi\/10.1093\/femspd\/ftx126\/4791527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,5]]},"references-count":92,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,5]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femspd\/ftx126","relation":{},"ISSN":["2049-632X"],"issn-type":[{"value":"2049-632X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2018,1,5]]}}}