{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:40:16Z","timestamp":1791726016658,"version":"4.3.4"},"reference-count":169,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF137"],"award-info":[{"award-number":["DNRF137"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["DFF-8048\u201300035B"],"award-info":[{"award-number":["DFF-8048\u201300035B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Many microbial secondary metabolites have been studied for decades primarily because of their antimicrobial properties. However, several of these metabolites also possess nonantimicrobial functions, both influencing the physiology of the producer and their ecological neighbors. An example of a versatile bacterial secondary metabolite with multiple functions is the tropone derivative tropodithietic acid (TDA). TDA is a broad-spectrum antimicrobial compound produced by several members of the Rhodobacteraceae family, a major marine bacterial lineage, within the genera Phaeobacter, Tritonibacter, and Pseudovibrio. The production of TDA is governed by the mode of growth and influenced by the availability of nutrient sources. The antibacterial effect of TDA is caused by disruption of the proton motive force of target microorganisms and, potentially, by its iron-chelating properties. TDA also acts as a signaling molecule, affecting gene expression in other bacteria, and altering phenotypic traits such as motility, biofilm formation, and antibiotic production in the producer. In microbial communities, TDA-producing bacteria cause a reduction of the relative abundance of closely related species and some fast-growing heterotrophic bacteria. Here, we summarize the current understanding of the chemical ecology of TDA, including the environmental niches of TDA-producing bacteria, and the molecular mechanisms governing the function and regulation of TDA.<\/jats:p>","DOI":"10.1093\/femsre\/fuac007","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T07:12:41Z","timestamp":1643267561000},"source":"Crossref","is-referenced-by-count":56,"title":["Role is in the eye of the beholder\u2014the multiple functions of the antibacterial compound tropodithietic acid produced by marine\n                    <i>Rhodobacteraceae<\/i>"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-6346","authenticated-orcid":false,"given":"Nathalie N S E","family":"Henriksen","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Biomedicine, Technical University of Denmark, S\u00f8ltofts, Plads Bldg. 221, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-0767","authenticated-orcid":false,"given":"Laura L","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biomedicine, Technical University of Denmark, S\u00f8ltofts, Plads Bldg. 221, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-0949","authenticated-orcid":false,"given":"Mario","family":"Wibowo","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biomedicine, Technical University of Denmark, S\u00f8ltofts, Plads Bldg. 221, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-5100","authenticated-orcid":false,"given":"Eva C","family":"Sonnenschein","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biomedicine, Technical University of Denmark, S\u00f8ltofts, Plads Bldg. 221, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-9845","authenticated-orcid":false,"given":"Mikkel","family":"Bentzon-Tilia","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biomedicine, Technical University of Denmark, S\u00f8ltofts, Plads Bldg. 221, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-5723","authenticated-orcid":false,"given":"Lone","family":"Gram","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biomedicine, Technical University of Denmark, S\u00f8ltofts, Plads Bldg. 221, DK-2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"2022050617042907000_bib1","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1073\/pnas.1504076112","article-title":"Socially mediated induction and suppression of antibiosis during bacterial coexistence","volume":"112","author":"Abrudan","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-018-4809-4","article-title":"Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species","volume":"19","author":"Adamek","year":"2018","journal-title":"BMC Genomics"},{"key":"2022050617042907000_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11101-012-9229-5","article-title":"Microbial diversity of Alcyoniumdigitatum","volume":"12","author":"Alsmark","year":"2013","journal-title":"Phytochem Rev"},{"key":"2022050617042907000_bib4","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1021\/ic9016883","article-title":"Vibrioferrin, an unusual marine siderophore: iron binding, photochemistry, and biological implications","volume":"48","author":"Amin","year":"2009","journal-title":"Inorg Chem"},{"key":"2022050617042907000_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature14488","article-title":"Interaction and signalling between a cosmopolitan phytoplankton and associated bacteria","volume":"522","author":"Amin","year":"2015","journal-title":"Nature"},{"key":"2022050617042907000_bib6","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1128\/JB.00429-09","article-title":"Genetic determinants of Silicibacter sp. TM1040 motility","volume":"191","author":"Belas","year":"2009","journal-title":"J Bacteriol"},{"key":"2022050617042907000_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ja.2005.1","article-title":"Bioactive microbial metabolites","volume":"58","author":"B\u00e9rdy","year":"2005","journal-title":"J Antibiot"},{"key":"2022050617042907000_bib8","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1128\/AEM.07657-11","article-title":"Genetic analysis of the upper phenylacetate catabolic pathway in the production of tropodithietic acid by Phaeobactergallaeciensis","volume":"78","author":"Berger","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib9","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1128\/JB.05818-11","article-title":"Tropodithietic acid production in Phaeobactergallaeciensis is regulated by N-acyl homoserine lactone-mediated quorum sensing","volume":"193","author":"Berger","year":"2011","journal-title":"J Bacteriol"},{"key":"2022050617042907000_bib10","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.1128\/AEM.06038-11","article-title":"Marine bacteria from danish coastal waters show antifouling activity against the marine fouling bacterium Pseudoalteromonas sp. strain S91 and zoospores of the green alga Ulvaaustralis independent of bacteriocidal activity","volume":"77","author":"Bernbom","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib11","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1038\/s41598-017-00784-7","article-title":"Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacterinhibens","volume":"7","author":"Beyersmann","year":"2017","journal-title":"Sci Rep"},{"key":"2022050617042907000_bib12","doi-asserted-by":"crossref","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"AntiSMASH 5.0: updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2022050617042907000_bib13","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/1462-2920.12123","article-title":"The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis","volume":"15","author":"Bondarev","year":"2013","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib14","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1099\/ijsem.0.001879","article-title":"Phaeobacter porticola sp. nov., an antibiotic-producing bacterium isolated from a sea harbour","volume":"67","author":"Breider","year":"2017","journal-title":"Int J Syst Evol Microbiol"},{"key":"2022050617042907000_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2014.00416","article-title":"Genome-scale data suggest reclassifications in the Leisingera-Phaeobacter cluster including proposals for Sedimentitalea gen. nov. and Pseudophaeobacter gen. nov","volume":"5","author":"Breider","year":"2014","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/1462-2920.12904","article-title":"Changes in secondary metabolic profiles of Microcystisaeruginosa strains in response to intraspecific interactions","volume":"18","author":"Briand","year":"2016","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib17","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/AEM.70.4.2560-2565.2003","article-title":"Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates","volume":"70","author":"Brinkhoff","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib18","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1039\/c4cc01924e","article-title":"Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacterinhibens","volume":"50","author":"Brock","year":"2014","journal-title":"Chem Commun"},{"key":"2022050617042907000_bib19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/AEM.02238-06","article-title":"Production of antibacterial compounds and biofilm formation by Roseobacter species are influenced by culture conditions","volume":"73","author":"Bruhn","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib20","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/AEM.72.4.3011-3015.2006","article-title":"Culture conditions of roseobacter strain 27-4 affect its attachment and biofilm formation as quantified by real-time PCR","volume":"72","author":"Bruhn","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib21","doi-asserted-by":"crossref","first-page":"7263","DOI":"10.1128\/AEM.71.11.7263-7270.2005","article-title":"Ecology, inhibitory activity, and morphogenesis of a marine antagonistic bacterium belonging to the Roseobacter clade","volume":"71","author":"Bruhn","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib22","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1128\/AEM.71.10.5665-5677.2005","article-title":"Overview of the marine Roseobacter lineage","volume":"71","author":"Buchan","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib23","doi-asserted-by":"crossref","first-page":"e02700","DOI":"10.1128\/mBio.02700-21","article-title":"Vertical inheritance facilitates interspecies diversification in biosynthetic gene clusters and specialized metabolites","volume":"12","author":"Chase","year":"2021","journal-title":"MBio"},{"key":"2022050617042907000_bib24","first-page":"1","article-title":"Surfactin: a quorum-sensing signal molecule to relieve CCR in Bacillusamyloliquefaciens","volume":"11","author":"Chen","year":"2020","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1039\/C9NP00048H","article-title":"Evolutionary dynamics of natural product biosynthesis in bacteria","volume":"37","author":"Chevrette","year":"2020","journal-title":"Nat Prod Rep"},{"key":"2022050617042907000_bib26","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/rcm.8226","article-title":"High-performance liquid chromatography\/electrospray ionisation mass spectrometric characterisation of metabolites produced by Pseudovibrio sp. W64, a marine sponge derived bacterium isolated from Irish waters","volume":"32","author":"Choudhary","year":"2018","journal-title":"Rapid Commun Mass Spectrom"},{"key":"2022050617042907000_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrmicro2977","article-title":"Competition sensing: the social side of bacterial stress responses","volume":"11","author":"Cornforth","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"2022050617042907000_bib28","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.3390\/md12125916","article-title":"Marine Pseudovibrio sp. as a novel source of antimicrobials","volume":"12","author":"Crowley","year":"2014","journal-title":"Mar Drugs"},{"key":"2022050617042907000_bib29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro2653","article-title":"Catabolism of dimethylsulphoniopropionate: microorganisms, enzymes and genes","volume":"9","author":"Curson","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"2022050617042907000_bib30","volume-title":"Biochemie Der Pflanzen","author":"Czapek","year":"1922","edition":"3rd edn"},{"key":"2022050617042907000_bib31","doi-asserted-by":"crossref","first-page":"e43996","DOI":"10.1371\/journal.pone.0043996","article-title":"Phaeobacter gallaeciensis reduces Vibrioanguillarum in cultures of microalgae and rotifers, and prevents vibriosis in cod larvae","volume":"7","author":"D'Alvise","year":"2012","journal-title":"PLoS ONE"},{"key":"2022050617042907000_bib32","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/1462-2920.12265","article-title":"Biofilm formation and antibiotic production in Ruegeriamobilis are influenced by intracellular concentrations of cyclic dimeric guanosinmonophosphate","volume":"16","author":"D'Alvise","year":"2014","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib33","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1128\/AEM.02717-09","article-title":"Inactivation of Vibrioanguillarum by attached and planktonic roseobacter cells","volume":"76","author":"D'Alvise","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib34","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1128\/AEM.02992-15","article-title":"Influence of iron on production of the antibacterial compound tropodithietic acid and its noninhibitory analog in Phaeobacterinhibens","volume":"82","author":"D'Alvise","year":"2016","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2021.657407","article-title":"Surfactin facilitates horizontal gene transfer in Bacillussubtilis","volume":"12","author":"Danev\u010di\u010d","year":"2021","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/AEM.66.2.467-475.2000","article-title":"Bacterial primary colonization and early succession on surfaces in marine waters as determined by amplified rRNA gene restriction analysis and sequence analysis of 16S rRNA genes","volume":"66","author":"Dang","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046718","article-title":"Pyocyanin promotes extracellular DNA release in Pseudomonasaeruginosa","volume":"7","author":"Das","year":"2012","journal-title":"PLoS ONE"},{"key":"2022050617042907000_bib38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ja.2013.61","article-title":"Specialized microbial metabolites: functions and origins","volume":"66","author":"Davies","year":"2013","journal-title":"J Antibiot"},{"key":"2022050617042907000_bib39","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/cbic.201700358","article-title":"Characterisation of the l-cystine \u03b2-lyase PatB from Phaeobacterinhibens: an enzyme involved in the biosynthesis of the marine antibiotic tropodithietic acid","volume":"18","author":"Dickschat","year":"2017","journal-title":"ChemBioChem"},{"key":"2022050617042907000_bib40","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1365-2958.2006.05306.x","article-title":"The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonasaeruginosa","volume":"61","author":"Dietrich","year":"2006","journal-title":"Mol Microbiol"},{"key":"2022050617042907000_bib41","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/1758-2229.12771","article-title":"Tropodithietic acid induces oxidative stress response, cell envelope biogenesis and iron uptake in Vibriovulnificus","volume":"11","author":"Dittmann","year":"2019","journal-title":"Environ Microbiol Rep"},{"key":"2022050617042907000_bib42","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/1751-7915.12877","article-title":"The aquaculture microbiome at the centre of business creation","volume":"10","author":"Dittmann","year":"2017","journal-title":"Microb Biotechnol"},{"key":"2022050617042907000_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AEM.00499-20","article-title":"Changes in the microbiome of mariculture feed organisms after treatment with a potentially probiotic strain of Phaeobacterinhibens","volume":"86","author":"Dittmann","year":"2020","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/1758-2229.12698","article-title":"Impact of Phaeobacterinhibens on marine eukaryote-associated microbial communities","volume":"11","author":"Dittmann","year":"2019","journal-title":"Environ Microbiol Rep"},{"key":"2022050617042907000_bib45","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1002\/cbic.201900786","article-title":"Bacterial tropone natural products and derivatives: overview of their biosynthesis, bioactivities, ecological role and biotechnological potential","volume":"21","author":"Duan","year":"2020","journal-title":"ChemBioChem"},{"key":"2022050617042907000_bib46","doi-asserted-by":"crossref","first-page":"10413","DOI":"10.1021\/jacs.1c04996","article-title":"A flavoprotein dioxygenase steers bacterial tropone biosynthesis via coenzyme A-ester oxygenolysis and ring epoxidation","volume":"143","author":"Duan","year":"2021","journal-title":"J Am Chem Soc"},{"key":"2022050617042907000_bib47","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1128\/AEM.72.5.3724-3732.2006","article-title":"Characterization of a culturable alphaproteobacterial symbiont common to many marine sponges and evidence for vertical transmission via sponge larvae","volume":"72","author":"Enticknap","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib48","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1046\/j.1365-2958.2000.02098.x","article-title":"The evolution of secondary metabolism - a unifying model","volume":"37","author":"Firn","year":"2000","journal-title":"Mol Microbiol"},{"key":"2022050617042907000_bib49","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1073\/pnas.0709132105","article-title":"The evolution of gene collectives: how natural selection drives chemical innovation","volume":"105","author":"Fischbach","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib50","first-page":"226","article-title":"On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of Bacillusinfluenzae","volume":"10","author":"Fleming","year":"1929","journal-title":"Br J Exp Pathol"},{"key":"2022050617042907000_bib51","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.cub.2012.08.005","article-title":"Competition, not cooperation, dominates interactions among culturable microbial species","volume":"22","author":"Foster","year":"2012","journal-title":"Curr Biol"},{"key":"2022050617042907000_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.01659","article-title":"Adaptation of surface-associated bacteria to the open ocean: a genomically distinct subpopulation of Phaeobactergallaeciensis colonizes pacific mesozooplankton","volume":"8","author":"Freese","year":"2017","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib54","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1111\/1462-2920.13700","article-title":"Ecological implications of hypoxia-triggered shifts in secondary metabolism","volume":"19","author":"Gallagher","year":"2017","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib55","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41564-019-0664-6","article-title":"Spatial metabolomics of in situ host\u2013microbe interactions at the micrometre scale","volume":"5","author":"Geier","year":"2020","journal-title":"Nat Microbiol"},{"key":"2022050617042907000_bib56","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1128\/JB.00410-10","article-title":"Expression of tropodithietic acid biosynthesis is controlled by a novel autoinducer","volume":"192","author":"Geng","year":"2010","journal-title":"J Bacteriol"},{"key":"2022050617042907000_bib57","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1128\/JB.00323-11","article-title":"TdaA regulates tropodithietic acid synthesis by binding to the tdaC promoter region","volume":"193","author":"Geng","year":"2011","journal-title":"J Bacteriol"},{"key":"2022050617042907000_bib58","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1128\/AEM.02339-07","article-title":"Genetic dissection of tropodithietic acid biosynthesis by marine roseobacters","volume":"74","author":"Geng","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2016.01155","article-title":"Changes in the structure of the microbial community associated with Nannochloropsissalina following treatments with antibiotics and bioactive compounds","volume":"7","author":"Geng","year":"2016","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib60","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1073\/pnas.252607699","article-title":"Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics","volume":"99","author":"Goh","year":"2002","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib61","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1128\/aem.63.11.4237-4242.1997","article-title":"Numerical dominance of a group of marine bacteria in the alpha-subclass of the class proteobacteria in coastal seawater","volume":"63","author":"Gonz\u00e1lez","year":"1997","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib62","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1128\/AEM.66.10.4237-4246.2000","article-title":"Bacterial community structure associated with a dimethylsulfoniopropionate-producing North Atlantic algal bloom","volume":"66","author":"Gonzalez","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib63","doi-asserted-by":"crossref","first-page":"R1176","DOI":"10.1016\/j.cub.2020.08.007","article-title":"Trophic interactions and the drivers of microbial community assembly","volume":"30","author":"Gralka","year":"2020","journal-title":"Curr Biol"},{"key":"2022050617042907000_bib64","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/AEM.68.8.4111-4116.2002","article-title":"Possible quorum sensing in marine snow bacteria: production of acylated homoserine lactones by Roseobacter strains isolated from marine snow","volume":"68","author":"Gram","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib65","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10126-009-9233-y","article-title":"Antibacterial activity of marine culturable bacteria collected from a global sampling of ocean surface waters and surface swabs of marine organisms","volume":"12","author":"Gram","year":"2010","journal-title":"Mar Biotechnol"},{"key":"2022050617042907000_bib66","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.syapm.2015.07.006","article-title":"Phaeobacter inhibens from the Roseobacter clade has an environmental niche as a surface colonizer in harbors","volume":"38","author":"Gram","year":"2015","journal-title":"Syst Appl Microbiol"},{"key":"2022050617042907000_bib67","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.aquaculture.2016.05.001","article-title":"Phaeobacter inhibens as probiotic bacteria in non-axenic Artemia and algae cultures","volume":"462","author":"Grotkj\u00e6r","year":"2016","journal-title":"Aquaculture"},{"key":"2022050617042907000_bib68","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.syapm.2016.01.005","article-title":"Isolation of TDA-producing Phaeobacter strains from sea bass larval rearing units and their probiotic effect against pathogenic Vibrio spp. in Artemia cultures","volume":"39","author":"Grotkj\u00e6r","year":"2016","journal-title":"Syst Appl Microbiol"},{"key":"2022050617042907000_bib69","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.3390\/md12125960","article-title":"Characterisation of non-autoinducing tropodithietic acid (TDA) production from marine sponge Pseudovibrio species","volume":"12","author":"Harrington","year":"2014","journal-title":"Mar Drugs"},{"key":"2022050617042907000_bib70","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1007\/PL00000796","article-title":"Extracellular electron transfer","volume":"58","author":"Hernandez","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"2022050617042907000_bib71","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1078\/0723-2020-00256","article-title":"Selection and identification of autochthonous potential probiotic bacteria from turbot larvae (Scophthalmus maximus) rearing units","volume":"27","author":"Hjelm","year":"2004","journal-title":"Syst Appl Microbiol"},{"key":"2022050617042907000_bib72","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.1128\/AEM.70.12.7288-7294.2004","article-title":"Seasonal incidence of autochthonous antagonistic Roseobacter spp. and Vibrionaceae strains in a turbot larva (Scophthalmus maximus) rearing system","volume":"70","author":"Hjelm","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib73","doi-asserted-by":"crossref","first-page":"e01774","DOI":"10.1128\/mBio.01774-21","article-title":"Surfactin stimulated by pectin molecular patterns and root exudates acts as a key driver of Bacillus-plant mutualistic interaction","volume":"12","author":"Hoff","year":"2021","journal-title":"mBio"},{"key":"2022050617042907000_bib74","first-page":"225","article-title":"Production of thiotropocin by a marine bacterium, Caulobacter sp. and its antimicroalgal activities","volume":"5","author":"Kawano","year":"1997","journal-title":"J Mar Biotechnol"},{"key":"2022050617042907000_bib75","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1128\/AEM.65.10.4549-4558.1999","article-title":"Dimethylsulfoniopropionate and methanethiol are important precursors of methionine and protein-sulfur in marine bacterioplankton","volume":"65","author":"Kiene","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib76","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.7164\/antibiotics.37.1294","article-title":"Thiotropocin, a new sulfur-containing 7-membered-ring antibiotic produced by a Pseudomonas sp","volume":"37","author":"Kintaka","year":"1984","journal-title":"J Antibiot"},{"key":"2022050617042907000_bib77","first-page":"181","author":"Kossel","year":"1891","journal-title":"\u00dcber die chemische zusammensetzung der zelle"},{"key":"2022050617042907000_bib79","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.vetmic.2008.05.014","article-title":"Isolation of putative probionts from cod rearing environment","volume":"132","author":"Lauzon","year":"2008","journal-title":"Vet Microbiol"},{"key":"2022050617042907000_bib80","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10482-014-0318-x","article-title":"Phaeobacter marinintestinus sp. nov., isolated from the intestine of a sea cucumber (Apostichopus japonicus)","volume":"107","author":"Lee","year":"2015","journal-title":"Antonie Van Leeuwenhoek"},{"key":"2022050617042907000_bib81","doi-asserted-by":"crossref","first-page":"e2021483118","DOI":"10.1073\/pnas.2021483118","article-title":"Piperacillin triggers virulence factor biosynthesis via the oxidative stress response in Burkholderiathailandensis","volume":"118","author":"Li","year":"2021","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib82","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/cbic.201200536","article-title":"A backup plan for self-protection: s-methylation of holomycin biosynthetic intermediates in Streptomycesclavuligerus","volume":"13","author":"Li","year":"2013","journal-title":"ChemBioChem"},{"key":"2022050617042907000_bib78","article-title":"Investigation of secondary metabolites of North Sea bacteria: fermentation, isolation, structure elucidation and bioactivity","author":"Liang","year":"2003"},{"key":"2022050617042907000_bib83","doi-asserted-by":"crossref","first-page":"19484","DOI":"10.1073\/pnas.0608949103","article-title":"Antibiotics as intermicrobiol signaling agents instead of weapons","volume":"103","author":"Linares","year":"2006","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib84","doi-asserted-by":"crossref","first-page":"e2003583","DOI":"10.1371\/journal.pbio.2003583","article-title":"Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species","volume":"15","author":"Lind","year":"2017","journal-title":"PLoS Biol"},{"key":"2022050617042907000_bib85","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/1574-6968.12086","article-title":"Antibiotics at subinhibitory concentrations improve the quorum sensing behavior of Chromobacteriumviolaceum","volume":"341","author":"Liu","year":"2013","journal-title":"FEMS Microbiol Lett"},{"key":"2022050617042907000_bib86","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1128\/AEM.67.11.4975-4983.2001","article-title":"Antagonistic interactions among marine pelagic bacteria","volume":"67","author":"Long","year":"2001","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib87","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1073\/pnas.0810940106","article-title":"Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillussubtilis","volume":"106","author":"L\u00f3pez","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib88","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/1462-2920.13253","article-title":"Effect of interspecific competition on trait variation in Phaeobacterinhibens biofilms","volume":"18","author":"Lutz","year":"2016","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsec\/fiz060","article-title":"Phaeobacter inhibens controls bacterial community assembly on a marine diatom","volume":"95","author":"Majzoub","year":"2019","journal-title":"FEMS Microbiol Ecol"},{"key":"2022050617042907000_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.02601","article-title":"Causes and consequences of a variant strain of Phaeobacterinhibens with reduced competition","volume":"9","author":"Majzoub","year":"2018","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib91","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00769-21","article-title":"Genomic evolution of the marine bacterium Phaeobacterinhibens during biofilm growth","volume":"87","author":"Majzoub","year":"2021","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib92","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.3390\/md9122537","article-title":"Inhibition of virulence gene expression in Staphylococcusaureus by novel depsipeptides from a marine Photobacterium","volume":"9","author":"Mansson","year":"2011","journal-title":"Mar Drugs"},{"key":"2022050617042907000_bib93","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00248-006-9165-2","article-title":"Bacteria of the Roseobacter clade show potential for secondary metabolite production","volume":"54","author":"Martens","year":"2007","journal-title":"Microb Ecol"},{"key":"2022050617042907000_bib94","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1099\/ijs.0.63724-0","article-title":"Reclassification of Roseobactergallaeciensis Ruiz-Ponte et al. 1998 as Phaeobactergallaeciensis gen. nov., comb. nov., description of Phaeobacterinhibens sp. nov., reclassification of Ruegeriaalgicola (Lafay et al. 1995) Uchino et al. 1999 as Marinovum algicola gen. nov., comb. nov., and emended descriptions of the genera Roseobacter, Ruegeria and Leisingera","volume":"56","author":"Martens","year":"2006","journal-title":"Int J Syst Evol Microbiol"},{"key":"2022050617042907000_bib95","doi-asserted-by":"crossref","first-page":"e1004016","DOI":"10.1371\/journal.pcbi.1004016","article-title":"A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis","volume":"10","author":"Medema","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"2022050617042907000_bib96","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1128\/AEM.70.6.3383-3391.2004","article-title":"Dimethylsulfoniopropionate metabolism by Pfiesteria-associated Roseobacter spp","volume":"70","author":"Miller","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib97","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1128\/AEM.70.8.4692-4701.2004","article-title":"Chemotaxis of silicibacter sp. strain TM1040 toward dinoflagellate products","volume":"70","author":"Miller","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib98","doi-asserted-by":"crossref","first-page":"13811","DOI":"10.1073\/pnas.1206855109","article-title":"Interkingdom metabolic transformations captured by microbial imaging mass spectrometry","volume":"109","author":"Moree","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib99","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1099\/ijs.0.64572-0","article-title":"Ruegeria mobilis sp. nov., a member of the alphaproteobacteria isolated in Japan and Palau","volume":"57","author":"Muramatsu","year":"2007","journal-title":"Int J Syst Evol Microbiol"},{"key":"2022050617042907000_bib100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00248-019-01380-0","article-title":"Diversity and distribution of bacteria producing known secondary metabolites","volume":"78","author":"Nappi","year":"2019","journal-title":"Microb Ecol"},{"key":"2022050617042907000_bib101","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/ismej.2009.150","article-title":"Genome characteristics of a generalist marine bacterial lineage","volume":"4","author":"Newton","year":"2010","journal-title":"ISME J"},{"key":"2022050617042907000_bib102","doi-asserted-by":"crossref","first-page":"e00060","DOI":"10.1128\/mSystems.00060-19","article-title":"Marine chitinolytic Pseudoalteromonas represents an untapped reservoir of bioactive potential","volume":"4","author":"Paulsen","year":"2019","journal-title":"mSystems"},{"key":"2022050617042907000_bib103","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3390\/md9081391","article-title":"Identification of the antibacterial compound produced by the marine epiphytic bacterium Pseudovibrio sp. D323 and related sponge-associated bacteria","volume":"9","author":"Penesyan","year":"2011","journal-title":"Mar Drugs"},{"key":"2022050617042907000_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mSystems.00175-17","article-title":"In search of model ecological systems for understanding specialized metabolism","volume":"3","author":"Pessotti","year":"2018","journal-title":"mSystems"},{"key":"2022050617042907000_bib105","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1007\/s00253-013-4746-8","article-title":"Extrachromosomal, extraordinary and essential\u2014the plasmids of the Roseobacter clade","volume":"97","author":"Petersen","year":"2013","journal-title":"Appl Microbiol Biotechnol"},{"key":"2022050617042907000_bib106","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/acs.jnatprod.8b01097","article-title":"Isolation of methyl troposulfenin from Phaeobacterinhibens","volume":"82","author":"Phippen","year":"2019","journal-title":"J Nat Prod"},{"key":"2022050617042907000_bib107","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/mmi.14471","article-title":"On the possible ecological roles of antimicrobials","volume":"113","author":"Pishchany","year":"2020","journal-title":"Mol Microbiol"},{"key":"2022050617042907000_bib108","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.aquaculture.2005.11.039","article-title":"Probiotic effect in vivo of Roseobacter strain 27-4 against Vibrio(Listonella) Anguillarum infections in turbot (Scophthalmus maximus L.) larvae","volume":"255","author":"Planas","year":"2006","journal-title":"Aquaculture"},{"key":"2022050617042907000_bib109","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.fm.2016.01.005","article-title":"Phaeobacter inhibens as biocontrol agent against Vibriovulnificus in oyster models","volume":"57","author":"Porsby","year":"2016","journal-title":"Food Microbiol"},{"key":"2022050617042907000_bib110","doi-asserted-by":"crossref","first-page":"7356","DOI":"10.1128\/AEM.01738-08","article-title":"Phaeobacter and Ruegeria species of the Roseobacter clade colonize separate niches in a danish turbot (Scophthalmus maximus)-rearing farm and antagonize Vibrioanguillarum under different growth conditions","volume":"74","author":"Porsby","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib111","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1128\/AAC.01222-10","article-title":"Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select","volume":"55","author":"Porsby","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2022050617042907000_bib112","first-page":"107","article-title":"Inhibitory activity of Phaeobacter strains against aquaculture pathogenic bacteria","volume":"12","author":"Prado","year":"2009","journal-title":"Int Microbiol"},{"key":"2022050617042907000_bib113","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nchembio764","article-title":"Rethinking \u201csecondary\u201d metabolism: physiological roles for phenazine antibiotics","volume":"2","author":"Price-Whelan","year":"2006","journal-title":"Nat Chem Biol"},{"key":"2022050617042907000_bib114","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1128\/AEM.01436-13","article-title":"Disruption of cell-to-cell signaling does not abolish the antagonism of Phaeobactergallaeciensis toward the fish pathogen Vibrioanguillarum in algal systems","volume":"79","author":"Prol\u00a0Garc\u00eda","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib115","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/jam.12659","article-title":"Biofilm formation is not a prerequisite for production of the antibacterial compound tropodithietic acid in Phaeobacterinhibens DSM17395","volume":"117","author":"Prol\u00a0Garc\u00eda","year":"2014","journal-title":"J Appl Microbiol"},{"key":"2022050617042907000_bib116","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.3762\/bjoc.10.188","article-title":"Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid","volume":"10","author":"Rabe","year":"2014","journal-title":"Beilstein J Org Chem"},{"key":"2022050617042907000_bib117","doi-asserted-by":"crossref","first-page":"e2275","DOI":"10.7717\/peerj.2275","article-title":"Isolation of an antimicrobial compound produced by bacteria associated with reef-building corals","volume":"4","author":"Raina","year":"2016","journal-title":"PeerJ"},{"key":"2022050617042907000_bib118","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/AEM.02567-08","article-title":"Coral-associated bacteria and their role in the biogeochemical cycling of sulfur","volume":"75","author":"Raina","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib119","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.1128\/AEM.01543-07","article-title":"Low densities of epiphytic bacteria from the marine alga Ulvaaustralis inhibit settlement of fouling organisms","volume":"73","author":"Rao","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib120","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1128\/AEM.00449-06","article-title":"Microbial colonization and competition on the marine alga Ulvaaustralis","volume":"72","author":"Rao","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib121","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/1751-7915.13275","article-title":"Effect of TDA-producing Phaeobacterinhibens on the fish pathogen Vibrioanguillarum in non-axenic algae and copepod systems","volume":"11","author":"Rasmussen","year":"2018","journal-title":"Microb Biotechnol"},{"key":"2022050617042907000_bib122","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1128\/AEM.01047-16","article-title":"Vibrio anguillarum is genetically and phenotypically unaffected by long-term continuous exposure to the antibacterial compound tropodithietic acid","volume":"82","author":"Rasmussen","year":"2016","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib123","doi-asserted-by":"crossref","first-page":"734415","DOI":"10.1016\/j.aquaculture.2019.734415","article-title":"Combining probiotic Phaeobacterinhibens DSM17395 and broad-host-range vibriophage KVP40 against fish pathogenic vibrios","volume":"513","author":"Rasmussen","year":"2019","journal-title":"Aquaculture"},{"key":"2022050617042907000_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aaf.2019.12.001","article-title":"Probiotics in shellfish aquaculture","volume":"5","author":"Ring\u00f8","year":"2020","journal-title":"Aquacul Fish"},{"key":"2022050617042907000_bib126","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1128\/AEM.04167-14","article-title":"Phosphate limitation induces drastic physiological changes, virulence-related gene expression, and secondary metabolite production in Pseudovibrio sp. Strain FO-BEG1","volume":"81","author":"Romano","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AEM.02516-17","article-title":"Ecology and biotechnological potential of bacteria belonging to the genus Pseudovibrio","volume":"84","author":"Romano","year":"2018","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib127","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1021\/cr2000509","article-title":"Antibiotics as signal molecules","volume":"111","author":"Romero","year":"2011","journal-title":"Chem Rev"},{"key":"2022050617042907000_bib128","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1099\/00207713-48-2-537","article-title":"Roseobacter gallaeciensis sp. nov., a new marine bacterium isolated from rearings and collectors of the scallop Pectenmaximus","volume":"48","author":"Ruiz-Ponte","year":"1998","journal-title":"Int J Syst Bacteriol"},{"key":"2022050617042907000_bib129","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/PL00011751","article-title":"The benefit of a Roseobacter species on the survival of scallop larvae","volume":"1","author":"Ruiz-Ponte","year":"1999","journal-title":"Mar Biotechnol"},{"key":"2022050617042907000_bib130","doi-asserted-by":"crossref","first-page":"10684","DOI":"10.1073\/pnas.1706016114","article-title":"Antagonism correlates with metabolic similarity in diverse bacteria","volume":"114","author":"Russel","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib131","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1462-2920.2009.02027.x","article-title":"Antagonistic interactions among coral-associated bacteria","volume":"12","author":"Rypien","year":"2010","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.17473","article-title":"Dynamic metabolic exchange governs a marine algal-bacterial interaction","volume":"5","author":"Segev","year":"2016","journal-title":"Elife"},{"key":"2022050617042907000_bib133","doi-asserted-by":"crossref","first-page":"18343","DOI":"10.1021\/ja207172s","article-title":"Roseobacticides: small molecule modulators of an algal-bacterial symbiosis","volume":"133","author":"Seyedsayamdost","year":"2011","journal-title":"J Am Chem Soc"},{"key":"2022050617042907000_bib134","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nchem.1002","article-title":"The Jekyll-and-Hyde chemistry of Phaeobactergallaeciensis","volume":"3","author":"Seyedsayamdost","year":"2011","journal-title":"Nat Chem"},{"key":"2022050617042907000_bib135","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1574-6941.2008.00644.x","article-title":"Coral mucus-associated bacteria: a possible first line of defense","volume":"67","author":"Shnit-Orland","year":"2009","journal-title":"FEMS Microbiol Ecol"},{"key":"2022050617042907000_bib136","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/ismej.2016.198","article-title":"Phylogenomics of Rhodobacteraceae reveals evolutionary adaptation to marine and non-marine habitats","volume":"11","author":"Simon","year":"2017","journal-title":"ISME J"},{"key":"2022050617042907000_bib137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AEM.02581-20","article-title":"The Roseobacter-group bacterium phaeobacter as a safe probiotic solution for aquaculture","volume":"87","author":"Sonnenschein","year":"2021","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib138","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ismej.2016.111","article-title":"Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeriamobilis","volume":"11","author":"Sonnenschein","year":"2017","journal-title":"ISME J"},{"key":"2022050617042907000_bib139","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/1758-2229.12649","article-title":"Phylogenetic distribution of roseobacticides in the Roseobacter group and their effect on microalgae","volume":"10","author":"Sonnenschein","year":"2018","journal-title":"Environ Microbiol Rep"},{"key":"2022050617042907000_bib140","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1099\/ijsem.0.002331","article-title":"Phaeobacter piscinae sp. nov., a species of the Roseobacter group and potential aquaculture probiont","volume":"67","author":"Sonnenschein","year":"2017","journal-title":"Int J Syst Evol Microbiol"},{"key":"2022050617042907000_bib141","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1128\/JB.00162-06","article-title":"Interactions between Streptomycescoelicolor and Bacillussubtilis: role of surfactants in raising aerial structures","volume":"188","author":"Straight","year":"2006","journal-title":"J Bacteriol"},{"key":"2022050617042907000_bib142","doi-asserted-by":"crossref","first-page":"1261359","DOI":"10.1126\/science.1261359","article-title":"Structure and function of the global ocean microbiome","volume":"348","author":"Sunagawa","year":"2015","journal-title":"Science"},{"key":"2022050617042907000_bib143","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3389\/fmicb.2018.01742","article-title":"Production of prodiginines is part of a programmed cell death process in Streptomycescoelicolor","volume":"9","author":"Tenconi","year":"2018","journal-title":"Front Microbiol"},{"key":"2022050617042907000_bib144","first-page":"aem0241821","article-title":"Roseobacter group probiotics exhibit differential killing of fish pathogenic Tenacibaculum species","volume-title":"Appl Environ Microbiol","author":"Tesdorphf","year":"2022"},{"key":"2022050617042907000_bib145","doi-asserted-by":"crossref","first-page":"11021","DOI":"10.1074\/jbc.M110.196667","article-title":"Studies on the mechanism of ring hydrolysis in phenylacetate degradation","volume":"286","author":"Teufel","year":"2011","journal-title":"J Biol Chem"},{"key":"2022050617042907000_bib146","doi-asserted-by":"crossref","first-page":"14390","DOI":"10.1073\/pnas.1005399107","article-title":"Bacterial phenylalanine and phenylacetate catabolic pathway revealed","volume":"107","author":"Teufel","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib147","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1038\/ismej.2012.62","article-title":"Phaeobacter gallaeciensis genomes from globally opposite locations reveal high similarity of adaptation to surface life","volume":"6","author":"Thole","year":"2012","journal-title":"ISME J"},{"key":"2022050617042907000_bib148","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1111\/1462-2920.13381","article-title":"Native plasmids restrict growth of Phaeobacterinhibens DSM 17395: energetic costs of plasmids assessed by quantitative physiological analyses","volume":"18","author":"Trautwein","year":"2016","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib149","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1039\/C5NP00013K","article-title":"Natural products in soil microbe interactions and evolution","volume":"32","author":"Traxler","year":"2015","journal-title":"Nat Prod Rep"},{"key":"2022050617042907000_bib150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0040-4039(00)99900-3","article-title":"Structure of thiotropocin, a new sulfur-containing 7-membered antibiotic","volume":"25","author":"Tsubotani","year":"1984","journal-title":"Tetrahedron Lett"},{"key":"2022050617042907000_bib151","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1099\/mgen.0.000621","article-title":"Rhodococcus comparative genomics reveals a phylogenomic-dependent non-ribosomal peptide synthetase distribution: insights into biosynthetic gene cluster connection to an orphan metabolite","volume":"7","author":"Undabarrena","year":"2021","journal-title":"Microbial Genomics"},{"key":"2022050617042907000_bib152","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00248-010-9644-3","article-title":"Antimicrobial resistance of the coral pathogen Vibriocoralliilyticus and Caribbean sister phylotypes isolated from a diseased octocoral","volume":"59","author":"Vizcaino","year":"2010","journal-title":"Microb Ecol"},{"key":"2022050617042907000_bib153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.02118-15","article-title":"Investigation of the genetics and biochemistry of roseobacticide production in the Roseobacter clade bacterium Phaeobacter\u200b\u200b\u200b\u200b\u200b\u200b\u200b\u00a0inhibens","volume":"7","author":"Wang","year":"2016","journal-title":"MBio"},{"key":"2022050617042907000_bib154","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1021\/acs.orglett.7b02424","article-title":"Roseochelin b, an algaecidal natural product synthesized by the roseobacter Phaeobacterinhibens in response to algal sinapic acid","volume":"19","author":"Wang","year":"2017","journal-title":"Org Lett"},{"key":"2022050617042907000_bib155","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1462-2920.2007.01497.x","article-title":"Major differences of bacterial diversity and activity inside and outside of a natural iron-fertilized phytoplankton bloom in the Southern Ocean","volume":"10","author":"West","year":"2008","journal-title":"Environ Microbiol"},{"key":"2022050617042907000_bib156","doi-asserted-by":"crossref","DOI":"10.3390\/md14050089","article-title":"Dimethylsulfoniopropionate promotes process outgrowth in neural cells and exerts protective effects against tropodithietic acid","volume":"14","author":"Wichmann","year":"2016","journal-title":"Mar Drugs"},{"key":"2022050617042907000_bib157","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.3390\/md13127058","article-title":"Cytotoxic effects of tropodithietic acid on mammalian clonal cell lines of neuronal and glial origin","volume":"13","author":"Wichmann","year":"2015","journal-title":"Mar Drugs"},{"key":"2022050617042907000_bib158","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3354\/ame01443","article-title":"Latitudinal patterns in the abundance of major marine bacterioplankton groups","volume":"61","author":"Wietz","year":"2010","journal-title":"Aquat Microb Ecol"},{"key":"2022050617042907000_bib159","doi-asserted-by":"crossref","first-page":"e0177295","DOI":"10.1371\/journal.pone.0177295","article-title":"The limits to growth \u2013 energetic burden of the endogenous antibiotic tropodithietic acid in Phaeobacterinhibens DSM 17395","volume":"12","author":"Will","year":"2017","journal-title":"PLoS ONE"},{"key":"2022050617042907000_bib160","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1073\/pnas.1518034113","article-title":"Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the \u03b3-glutamyl cycle as a proton sink","volume":"113","author":"Wilson","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"2022050617042907000_bib161","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1099\/ijsem.0.002833","article-title":"Phylogenomic analyses of a clade within the roseobacter group suggest taxonomic reassignments of species of the genera Aestuariivita, Citreicella, Loktanella, Nautella, Pelagibaca, Ruegeria, Thalassobius, Thiobacimonas and Tropicibacter, and the proposal of six novel genera","volume":"68","author":"Wirth","year":"2018","journal-title":"Int J Syst Evol Microbiol"},{"key":"2022050617042907000_bib162","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000508591","article-title":"Global response of Phaeobacterinhibens DSM 17395 to deletion of its 262-kb chromid encoding antibiotic synthesis","volume":"30","author":"W\u00fcnsch","year":"2020","journal-title":"Microb Physiol"},{"key":"2022050617042907000_bib163","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10534-018-00163-3","article-title":"Distribution of dissolved iron and bacteria producing the photoactive siderophore, vibrioferrin, in waters off Southern California and Northern Baja","volume":"32","author":"Yarimizu","year":"2019","journal-title":"Biometals"},{"key":"2022050617042907000_bib164","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1098\/rstb.2007.2044","article-title":"Antibiotics as signalling molecules","volume":"362","author":"Yim","year":"2007","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"2022050617042907000_bib165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10295-013-1387-y","article-title":"Activating secondary metabolism with stress and chemicals","volume":"41","author":"Yoon","year":"2014","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2022050617042907000_bib166","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3390\/ijms15010654","article-title":"Acyl-homoserine lactone quorum sensing in the Roseobacter clade","volume":"15","author":"Zan","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2022050617042907000_bib167","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/pmic.201200560","article-title":"Dynamics of amino acid utilization in Phaeobacterinhibens DSM 17395","volume":"13","author":"Zech","year":"2013","journal-title":"Proteomics"},{"key":"2022050617042907000_bib168","doi-asserted-by":"crossref","first-page":"e00169","DOI":"10.1128\/AEM.00169-21","article-title":"Holomycin, an antibiotic secondary metabolite, is required for biofilm formation by the native producer Photobacteriumgalatheae S2753","volume":"87","author":"Zhang","year":"2021","journal-title":"Appl Environ Microbiol"},{"key":"2022050617042907000_bib169","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhazmat.2015.10.003","article-title":"Inhibition of marine Vibrio sp. by pyoverdine from Pseudomonasaeruginosa PA1","volume":"302","author":"Zhang","year":"2016","journal-title":"J Hazard Mater"},{"key":"2022050617042907000_bib170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-015-0617-z","article-title":"Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacterinhibens","volume":"16","author":"Zhao","year":"2016","journal-title":"BMC Microbiol"}],"container-title":["FEMS Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/femsre\/advance-article-pdf\/doi\/10.1093\/femsre\/fuac007\/42546807\/fuac007.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsre\/article-pdf\/46\/3\/fuac007\/43590797\/fuac007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsre\/article-pdf\/46\/3\/fuac007\/43590797\/fuac007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T13:11:00Z","timestamp":1651842660000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsre\/article\/doi\/10.1093\/femsre\/fuac007\/6517774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":169,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5,6]]}},"URL":"https:\/\/doi.org\/10.1093\/femsre\/fuac007","relation":{},"ISSN":["1574-6976"],"issn-type":[{"value":"1574-6976","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5]]},"published":{"date-parts":[[2022,1,31]]},"article-number":"fuac007"}}