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It can associate with any of 6 different light chains to form distinct amino acid transporters. CD98hc is also involved in mediation of intracellular integrin signaling. Besides its physiological roles in the development of the placenta and the immune system, CD98hc is important during pathological processes such as tumorigenesis and host\u2013pathogen interaction. Since its first identification as Fusion Regulatory Protein 1 regulating cell fusion in cells infected by the Newcastle disease virus, CD98hc has been reported to be mediating many viral, apicomplexan, and bacterial infectious processes. In this review we describe the role of CD98hc and its associated light chains in bacterial, apicomplexan, and viral pathogenesis. We also discuss the consequences of infection on the expression and localization of these proteins. The identification of the cellular processes in which CD98hc is involved during pathogenesis highlights the key role of this host protein in infectious diseases.<\/jats:p>","DOI":"10.1093\/femsre\/fuac023","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:57:32Z","timestamp":1653094652000},"source":"Crossref","is-referenced-by-count":8,"title":["CD98hc in host\u2013pathogen interactions: roles of the multifunctional host protein during infections"],"prefix":"10.1093","volume":"46","author":[{"given":"Sonia","family":"Vection","sequence":"first","affiliation":[{"name":"VBIC , U1047 INSERM, Universit\u00e9 de Montpellier, N\u00eemes, France"},{"name":"Laboratoire de Microbiologie Centre National de R\u00e9f\u00e9rence des Brucella , , CHU de N\u00eemes, N\u00eemes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"VBIC , U1047 INSERM, Universit\u00e9 de Montpellier, N\u00eemes, France"},{"name":"Laboratoire de Microbiologie, CHU de N\u00eemes Centre National de R\u00e9f\u00e9rence des Brucella , , N\u00eemes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-299X","authenticated-orcid":false,"given":"Anne","family":"Keriel","sequence":"additional","affiliation":[{"name":"VBIC , U1047 INSERM, Universit\u00e9 de Montpellier, N\u00eemes, France"},{"name":"Laboratoire de Microbiologie Centre National de R\u00e9f\u00e9rence des Brucella , , CHU de N\u00eemes, N\u00eemes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"2022090213083369600_bib1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/cmi.12151","article-title":"Identifying novel Plasmodiumfalciparum erythrocyte invasion receptors using systematic extracellular protein interaction 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