{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:27:12Z","timestamp":1791419232189,"version":"4.3.3"},"reference-count":195,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"NWO","doi-asserted-by":"publisher","award":["TTW-NACTAR-16445"],"award-info":[{"award-number":["TTW-NACTAR-16445"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"NWO","doi-asserted-by":"publisher","award":["TTW-NACTAR-16433"],"award-info":[{"award-number":["TTW-NACTAR-16433"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rise of multidrug-resistant bacteria underlines the need for innovative treatments, yet the introduction of new drugs has stagnated despite numerous antimicrobial discoveries. A major hurdle is a poor correlation between promising in vitro data and in vivo efficacy in animal models, which is essential for clinical development. Early in vivo testing is hindered by the expense and complexity of existing animal models. Therefore, there is a pressing need for cost-effective, rapid preclinical models with high translational value. To overcome these challenges, zebrafish embryos have emerged as an attractive model for infectious disease studies, offering advantages such as ethical alignment, rapid development, ease of maintenance, and genetic manipulability. The zebrafish embryo infection model, involving microinjection or immersion of pathogens and potential antibiotic hit compounds, provides a promising solution for early-stage drug screening. It offers a cost-effective and rapid means of assessing the efficacy, toxicity and mechanism of action of compounds in a whole-organism context. This review discusses the experimental design of this model, but also its benefits and challenges. Additionally, it highlights recently identified compounds in the zebrafish embryo infection model and discusses the relevance of the model in predicting the compound\u2019s clinical potential.<\/jats:p>","DOI":"10.1093\/femsre\/fuae011","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:51:52Z","timestamp":1714146712000},"source":"Crossref","is-referenced-by-count":40,"title":["Diving into drug-screening: zebrafish embryos as an\n                    <i>in vivo<\/i>\n                    platform for antimicrobial drug discovery and assessment"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0613-8564","authenticated-orcid":false,"given":"Eva","family":"Habjan","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location VU Medical Center , De Boelelaan 1108, 1081 HZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0685-9151","authenticated-orcid":false,"given":"Gina K","family":"Schouten","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location VU Medical Center , De Boelelaan 1108, 1081 HZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-5987","authenticated-orcid":false,"given":"Alexander","family":"Speer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location VU Medical Center , De Boelelaan 1108, 1081 HZ Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-1611","authenticated-orcid":false,"given":"Peter","family":"van\u00a0Ulsen","sequence":"additional","affiliation":[{"name":"Section Molecular Microbiology of A-LIFE, Vrije Universiteit , De Boelelaan 1085, 1081 HV Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-6511","authenticated-orcid":false,"given":"Wilbert","family":"Bitter","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location VU Medical Center , De Boelelaan 1108, 1081 HZ Amsterdam , The Netherlands"},{"name":"Section Molecular Microbiology of A-LIFE, Vrije Universiteit , De Boelelaan 1085, 1081 HV Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"2024050814452897700_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2011.02.022","article-title":"Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism","volume":"145","author":"Adams","year":"2011","journal-title":"Cell"},{"key":"2024050814452897700_bib2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3109\/00498254.2010.493960","article-title":"Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae","volume":"40","author":"Alderton","year":"2010","journal-title":"Xenobiotica"},{"key":"2024050814452897700_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0021076","article-title":"Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing","volume":"6","author":"Ali","year":"2011","journal-title":"PLoS ONE"},{"key":"2024050814452897700_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jama.281.1.61","article-title":"Trends in infectious disease mortality in the United States during the 20th century","volume":"281","author":"Armstrong","year":"1999","journal-title":"JAMA"},{"key":"2024050814452897700_bib5","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1080\/14756366.2017.1332056","article-title":"\u03b2-CA-specific inhibitor dithiocarbamate Fc14\u2013584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis","volume":"32","author":"Aspatwar","year":"2017","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2024050814452897700_bib6","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1007\/s00216-021-03476-4","article-title":"Mass spectrometry imaging in zebrafish larvae for assessing drug safety and metabolism","volume":"413","author":"Asslan","year":"2021","journal-title":"Anal BioanalChem"},{"key":"2024050814452897700_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a037077","article-title":"Zebrafish in vivo models of cancer and metastasis","volume":"10","author":"Astell","year":"2020","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2024050814452897700_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/MMBR.00067-15","article-title":"Strengths and limitations of model systems for the study of urinary tract infections and related pathologies","volume":"80","author":"Barber","year":"2016","journal-title":"Microbiol Mol Biol Rev"},{"key":"2024050814452897700_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/zeb.2016.1344","article-title":"Office of laboratory animal welfare comments","volume":"13","author":"Bartlett","year":"2016","journal-title":"Zebrafish"},{"key":"2024050814452897700_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21769\/BioProtoc.3536","article-title":"Zebrafish bacterial infection assay to study host-pathogen interactions","volume":"10","author":"Basheer","year":"2020","journal-title":"Bio-Protocol"},{"key":"2024050814452897700_bib11","first-page":"179","article-title":"The power of zebrafish in personalised medicine","volume-title":"Personalised Medicine, Advances in Experimental Medicine and Biology","author":"Baxendale","year":"2017"},{"key":"2024050814452897700_bib13","first-page":"3781","article-title":"Infection of zebrafish embryos with intracellular bacterial pathogens","author":"Benard","year":"2012","journal-title":"J Vis Exp"},{"key":"2024050814452897700_bib14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/infdis\/142.3.476","article-title":"Correlations between methods for measurement of synergy","volume":"142","author":"Berenbaum","year":"1980","journal-title":"J Infect Dis"},{"key":"2024050814452897700_bib15","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.celrep.2019.01.071","article-title":"CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defenses","volume":"26","author":"Bernut","year":"2019","journal-title":"Cell Rep"},{"key":"2024050814452897700_bib16","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1128\/AAC.00142-14","article-title":"In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system","volume":"58","author":"Bernut","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050814452897700_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/2211-5463.13094","article-title":"Nonclassical antagonism between human lysozyme and AMPs against Pseudomonas aeruginosa","volume":"11","author":"Blumenthal","year":"2021","journal-title":"FEBS Open Bio"},{"key":"2024050814452897700_bib18","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/1040841X.2018.1523132","article-title":"The zebrafish model of tuberculosis\u2014no lungs needed","volume":"44","author":"Bouz","year":"2018","journal-title":"Crit Rev Microbiol"},{"key":"2024050814452897700_bib19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1462-5822.2009.01288.x","article-title":"Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos","volume":"11","author":"Brannon","year":"2009","journal-title":"Cell Microbiol"},{"key":"2024050814452897700_bib20","first-page":"403","article-title":"Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish","volume":"140","author":"Bresolin","year":"2005","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"key":"2024050814452897700_bib21","first-page":"1","article-title":"Transgenic zebrafish (Danio rerio) as an emerging model system in ecotoxicology and toxicology: historical review, recent advances and trends","volume":"848","author":"Brito","year":"2022","journal-title":"Sci Total Environ"},{"key":"2024050814452897700_bib22","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1021\/acs.est.6b04325","article-title":"Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): influence of physicochemical properties and of biological processes","volume":"50","author":"Brox","year":"2016","journal-title":"Environ Sci Technol"},{"key":"2024050814452897700_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0016779","article-title":"A high-throughput screen for tuberculosis progression","volume":"6","author":"Carvalho","year":"2011","journal-title":"PLoS ONE"},{"key":"2024050814452897700_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2020.00456","article-title":"Histones, their variants and post-translational modifications in zebrafish development","volume":"8","author":"Cavalieri","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2024050814452897700_bib25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.vetimm.2008.04.003","article-title":"RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare","volume":"124","author":"Chang","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"key":"2024050814452897700_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.fsi.2019.06.029","article-title":"The protective effect of fish-derived cathelicidins on bacterial infections in zebrafish, Danio rerio","volume":"92","author":"Chen","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"2024050814452897700_bib27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"2024050814452897700_bib28","first-page":"1","article-title":"The effect of the chorion on size-dependent acute toxicity and underlying mechanisms of amine-modified silver nanoparticles in zebrafish embryos","volume":"21","author":"Chen","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2024050814452897700_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.synres.2019.100049","article-title":"Computerized quantification of drugs synergism in animal studies or in clinical trials using only ten data points","volume":"9","author":"Chou","year":"2019","journal-title":"Synergy"},{"key":"2024050814452897700_bib30","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/hep.23157","article-title":"A new school in liver development: lessons from zebrafish","volume":"50","author":"Chu","year":"2009","journal-title":"Hepatology"},{"key":"2024050814452897700_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.00801-20","article-title":"Zebrafish embryo model for assessment of drug efficacy on Mycobacterial Persisters","volume":"64","author":"Commandeur","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050814452897700_bib195_248_160324","first-page":"864","article-title":"ZeGlobalTox: an innovative approach to address organ drug toxicity using zebrafish","volume-title":"Int J Mol Sci","author":"Cornet","year":"2017"},{"key":"2024050814452897700_bib32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/cells9020293","article-title":"Zebrafish avatars towards personalized medicine\u2014a comparative review between avatar models","volume":"9","author":"Costa","year":"2020","journal-title":"Cells"},{"key":"2024050814452897700_bib33","first-page":"811","article-title":"Zebrafish earn their drug discovery stripes","volume":"18","author":"Cully","year":"2019","journal-title":"Nat Rev"},{"key":"2024050814452897700_bib34","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/jac\/dkw421","article-title":"Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model","volume":"72","author":"Dalton","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2024050814452897700_bib35","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/cells10020242","article-title":"Appendage regeneration in vertebrates: what makes this possible?","volume":"10","author":"Daponte","year":"2021","journal-title":"Cells"},{"key":"2024050814452897700_bib36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1074-7613(02)00475-2","article-title":"Real-time visualization of Mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos","volume":"17","author":"Davis","year":"2002","journal-title":"Immunity"},{"key":"2024050814452897700_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/bdrb.21166","article-title":"Visualizing compound distribution during zebrafish embryo development: the effects of lipophilicity and DMSO","volume":"104","author":"De\u00a0Koning","year":"2015","journal-title":"Birth Def Res"},{"key":"2024050814452897700_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ddmod.2012.02.005","article-title":"ADMETox in zebrafish","volume":"10","author":"Diekman","year":"2013","journal-title":"Drug Discov Tod Dis Models"},{"key":"2024050814452897700_bib39","first-page":"1","article-title":"PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus","volume":"24","author":"Dimer","year":"2020","journal-title":"Nanomedicine"},{"key":"2024050814452897700_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-17699-z","article-title":"Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization","volume":"11","author":"Doolin","year":"2020","journal-title":"Nat Commun"},{"key":"2024050814452897700_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2014.09.005","article-title":"Comparison of toxicity values across zebrafish early life stages and mammalian studies: implications for chemical testing","volume":"55","author":"Ducharme","year":"2015","journal-title":"Reprod Toxicol"},{"key":"2024050814452897700_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmedt.2021.640981","article-title":"Developing antimicrobial synergy with AMPs","volume":"3","author":"Duong","year":"2021","journal-title":"Front Med Technol"},{"key":"2024050814452897700_bib43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.tim.2018.01.005","article-title":"Evolutionary mechanisms shaping the maintenance of antibiotic resistance","volume":"26","author":"Durao","year":"2018","journal-title":"Trends Microbiol"},{"key":"2024050814452897700_bib44","volume-title":"Directive 2010\/63\/EU of the european parliament and of the council of 22 September 2010 on the protection of animals used for scienfitic purposes","author":"EC","year":"2010"},{"key":"2024050814452897700_bib45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/17425250902882128","article-title":"The use of in vivo zebrafish assays in drug toxicity screening","volume":"5","author":"Eimon","year":"2009","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2024050814452897700_bib46","volume-title":"DB-ALM Protocol n\u00b0 140 : Fish Embryo Acute Toxicity Test with Zebrafish (ZFET)","author":"European Commision","year":"2013"},{"key":"2024050814452897700_bib47","first-page":"25","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect Med Chem"},{"key":"2024050814452897700_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emi.2015.29","article-title":"Evaluation of zebrafish as a model to study the pathogenesis of the opportunistic pathogen Cronobacter turicensis","volume":"4","author":"Fehr","year":"2015","journal-title":"Emerg Microbes Infect"},{"key":"2024050814452897700_bib49","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1021\/acsnano.0c01870","article-title":"Polymersomes eradicating intracellular bacteria","volume":"14","author":"Fenaroli","year":"2020","journal-title":"ACS Nano"},{"key":"2024050814452897700_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms241612791","article-title":"Impact of drug administration routes on the in vivo efficacy of the natural product sorangicin a using a Staphylococcus aureus infection model in zebrafish embryos","volume":"24","author":"Fries","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024050814452897700_bib51","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev-pharmtox-052220-105907","article-title":"Non-P450 drug-metabolizing enzymes: contribution to drug disposition, toxicity, and development","volume":"62","author":"Fukami","year":"2022","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"2024050814452897700_bib52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tcb.2020.09.005","article-title":"Tracking mechanisms of viral dissemination in vivo","volume":"31","author":"Gaudin","year":"2020","journal-title":"Trends Cell Biol"},{"key":"2024050814452897700_bib53","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tig.2013.07.003","article-title":"The zebrafish as a model for complex tissue regeneration","volume":"29","author":"Gemberling","year":"2013","journal-title":"Trends Genet"},{"key":"2024050814452897700_bib54","first-page":"1","article-title":"Automated high-throughput heartbeat quantifcation in medaka and zebrafsh embryos under physiological conditions","volume":"10","author":"Gierten","year":"2020","journal-title":"Nat Sci Rep"},{"key":"2024050814452897700_bib55","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.immuni.2015.12.006","article-title":"Compendium of immune signatures identifies conserved and species-specific biology in response to inflammation","volume":"44","author":"Godec","year":"2016","journal-title":"Immunity"},{"key":"2024050814452897700_bib56","article-title":"Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish","volume":"5","author":"Goh","year":"2023","journal-title":"JAC Antimicrobial Resist"},{"key":"2024050814452897700_bib57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tim.2019.08.005","article-title":"The case for modeling human infection in zebrafish","volume":"28","author":"Gomes","year":"2020","journal-title":"Trends Microbiol"},{"key":"2024050814452897700_bib58","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3390\/ph14060576","article-title":"Pharmacokinetics in zebrafish embryos (ZFE) following immersion and intrayolk administration: a fluorescence-based analysis","volume":"14","author":"Guarin","year":"2021","journal-title":"Pharmaceuticals"},{"key":"2024050814452897700_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.049145","article-title":"An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor","volume":"14","author":"Habjan","year":"2021","journal-title":"Dis Models Mech"},{"key":"2024050814452897700_bib60","doi-asserted-by":"crossref","first-page":"113106","DOI":"10.1016\/j.ecoenv.2021.113106","article-title":"Hazard assessment of beta-lactams: integrating in silico and QSTR approaches with in vivo zebrafish embryo toxicity testing","volume":"229","author":"Han","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"2024050814452897700_bib61","first-page":"1","article-title":"Non-invasive imaging of the innate immune response in a zebrafish larval model of Streptococcus iniae infection","volume":"98","author":"Harvie","year":"2015","journal-title":"J Vis Exp"},{"key":"2024050814452897700_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/iai.00626-21","article-title":"Pseudomonas synergizes with fluconazole against Candida during treatment of polymicrobial infection","volume":"90","author":"Hattab","year":"2022","journal-title":"Infect Immun"},{"key":"2024050814452897700_bib63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cbpc.2010.09.003","article-title":"Dechorionation as a tool to improve the fish embryo toxicity test (FET) with the zebrafish (Danio rerio)","volume":"153","author":"Henn","year":"2011","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"2024050814452897700_bib64","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1242\/dev.126.17.3735","article-title":"Ontogeny and behaviour of early macrophages in the zebrafish embryo","volume":"126","author":"Herbomel","year":"1999","journal-title":"Development"},{"key":"2024050814452897700_bib65","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol Sci"},{"key":"2024050814452897700_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.01445-20","article-title":"Heterologous expression of ethA and katG in Mycobacterium marinum enables the rapid identification of new prodrugs active against Mycobacterium tuberculosis","volume":"65","author":"Ho","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050814452897700_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2021.746796","article-title":"Comparative study of human and murine aortic biomechanics and hemodynamics in vascular aging","volume":"12","author":"Hopper","year":"2021","journal-title":"Front Physiol"},{"key":"2024050814452897700_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26508\/lsa.202201476","article-title":"OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection","volume":"5","author":"Hortle","year":"2022","journal-title":"Life Sci Allian"},{"key":"2024050814452897700_bib69","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"2024050814452897700_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/ftox.2021.804033","article-title":"DMSO concentrations up to 1% are safe to be used in the zebrafish embryo developmental toxicity assay","volume":"3","author":"Hoyberghs","year":"2021","journal-title":"Front Toxicol"},{"key":"2024050814452897700_bib71","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0732-8893(93)90087-N","article-title":"Synergy assessed by checkerboard; a critical analysis","volume":"16","author":"Hsieh","year":"1993","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2024050814452897700_bib72","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.4103\/1673-5374.306059","article-title":"Inflammation induces zebrafish regeneration","volume":"16","author":"Iribarne","year":"2021","journal-title":"Neural Regen Res"},{"key":"2024050814452897700_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0655-y","article-title":"Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model","volume":"13","author":"Jim","year":"2016","journal-title":"J Neuroinflam"},{"key":"2024050814452897700_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.049159","article-title":"Mycobacteriophage-antibiotic therapy promotes enhanced clearence of drug-resistant Mycobacterium abscessus","volume":"14","author":"Johansen","year":"2021","journal-title":"Dis Models Mech"},{"key":"2024050814452897700_bib75","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.biochi.2021.10.014","article-title":"Musculoskeletal regeneration: a zebrafish perspective","volume":"196","author":"Kaliya-Perumal","year":"2022","journal-title":"Biochimie"},{"key":"2024050814452897700_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-018-2166-6","article-title":"An automatic method to calculate heart rate from zebrafish larval cardiac videos","volume":"19","author":"Kang","year":"2018","journal-title":"BMC Bioinf"},{"key":"2024050814452897700_bib77","first-page":"913","article-title":"Production of a compound against methicillin resistant Staphylococcus aureus (MRSA) from Streptomyces rubrolavendulae ICN3 and its evaluation in zebrafish embryos","volume":"139","author":"Kannan","year":"2014","journal-title":"Ind J Med Res"},{"key":"2024050814452897700_bib78","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1089\/zeb.2016.1313","article-title":"Pharmacokinetic modeling of paracetamol uptake and clearance in zebrafish larvae: expanding the allometric scale in vertebrates with five orders of magnitude","volume":"13","author":"Kantae","year":"2016","journal-title":"Zebrafish"},{"key":"2024050814452897700_bib79","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s1012601-0053-4","article-title":"Generating transparent zebrafish: a refined method to improve detection of gene expression during embryonic development","volume":"3","author":"Karlsson","year":"2001","journal-title":"Mar Biotechnol"},{"key":"2024050814452897700_bib80","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrd.2017.162","article-title":"Host-directed therapies for bacterial and viral infections","volume":"17","author":"Kaufmann","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"2024050814452897700_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.apjtb.2017.01.019","article-title":"Nosocomial infections: epidemiology, prevention, control and surveillance","volume":"7","author":"Khan","year":"2017","journal-title":"Asian Pac J Trop Biomed"},{"key":"2024050814452897700_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cimid.2020.101574","article-title":"Drug resistant tuberculosis: a review","volume":"74","author":"Khawbung","year":"2021","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"2024050814452897700_bib83","first-page":"1","article-title":"A screening of the MMV pandemic response box reveals epetraborole as a new potent inhibitor against Mycobacterium abscessus","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024050814452897700_bib84","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"2013","author":"Kimmel","year":"1995","journal-title":"Dev Dynam"},{"key":"2024050814452897700_bib85","first-page":"1","article-title":"The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds","volume":"15","author":"Knudsen\u00a0Dal","year":"2022","journal-title":"Dis Models Mech"},{"key":"2024050814452897700_bib86","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09657","article-title":"The challenge of new drug discovery for tuberculosis","volume":"469","author":"Koul","year":"2011","journal-title":"Nature"},{"key":"2024050814452897700_bib87","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00281-015-0538-9","article-title":"Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies","volume":"38","author":"Kramnik","year":"2016","journal-title":"Semin Immunopathol"},{"key":"2024050814452897700_bib88","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2144\/000112257","article-title":"CellProfiler: free, versatile software for automated biological image analysis","volume":"42","author":"Lamprecht","year":"2007","journal-title":"BioTechniques"},{"key":"2024050814452897700_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-015-0579-2","article-title":"Analysis of zebrafish (Danio rerio) behavior in response to bacterial infection using a self-organizing map","volume":"11","author":"Lee","year":"2015","journal-title":"BMC Vet Res"},{"key":"2024050814452897700_bib90","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.mib.2008.05.013","article-title":"Insights into early mycobacterial pathogenesis from the zebrafish","volume":"11","author":"Lesley","year":"2008","journal-title":"Curr Opin Microbiol"},{"key":"2024050814452897700_bib91","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jgg.2012.07.006","article-title":"Establishment of multi-site infection model in zebrafish larvae for studying Staphylococcus aureus infectious disease","volume":"39","author":"Li","year":"2012","journal-title":"J Genet Genomics"},{"key":"2024050814452897700_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.01094","article-title":"The diverse roles of phagocytes during bacterial and fungal infections and sterile inflammation: lessons from zebrafish","volume":"11","author":"Linnerz","year":"2020","journal-title":"Front Immunol"},{"key":"2024050814452897700_bib93","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0925-4773(01)00658-X","article-title":"Cloning and expression pattern of the lysozyme C gene in zebrafish","volume":"113","author":"Liu","year":"2002","journal-title":"Mech Dev"},{"key":"2024050814452897700_bib94","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/acsmedchemlett.9b00063","article-title":"Do Zebrafish Obey Lipinski Rules?","volume":"10","author":"Long","year":"2019","journal-title":"ACS Med Chem Lett"},{"key":"2024050814452897700_bib95","first-page":"721","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat Rev"},{"key":"2024050814452897700_bib96","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/emmm.201303575","article-title":"Towards a new combination therapy for tuberculosis with next generation benzothiazinones","volume":"6","author":"Makarov","year":"2014","journal-title":"EMBO Mol Med"},{"key":"2024050814452897700_bib97","first-page":"1","article-title":"\u03b2-lactamase inhibitory potential of kalafungin from marine Streptomyces in Staphylococcus aureus infected zebrafish","volume":"244","author":"Mary","year":"2021","journal-title":"Microbiol Res"},{"key":"2024050814452897700_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.39123","article-title":"Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection","volume":"8","author":"Matty","year":"2019","journal-title":"eLife"},{"key":"2024050814452897700_bib99","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.drudis.2008.03.002","article-title":"Zebrafish: a predictive model for assessing drug-induced toxicity","volume":"13","author":"McGrath","year":"2008","journal-title":"Drug Discov Tod"},{"key":"2024050814452897700_bib100","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.dci.2007.11.011","article-title":"Immunology and zebrafish: spawning new models of human disease","volume":"32","author":"Meeker","year":"2008","journal-title":"Dev Compar Immunol"},{"key":"2024050814452897700_bib101","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00281-015-0522-4","article-title":"Protection and pathology in TB: learning from the zebrafish model","volume":"38","author":"Meijer","year":"2016","journal-title":"Semin Immunopathol"},{"key":"2024050814452897700_bib102","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"key":"2024050814452897700_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.66080","article-title":"In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish","volume":"11","author":"Miskolci","year":"2022","journal-title":"eLife"},{"key":"2024050814452897700_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.00036","article-title":"Functional inhibition of host histone deacetylases (HDACs) enhances in vitro and in vivo anti-mycobacterial activity in human macrophages and in zebrafish","volume":"11","author":"Moreira","year":"2020","journal-title":"Front Immunol"},{"key":"2024050814452897700_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25173974","article-title":"Evaluation of the percutaneous absorption of drug molecules in zebrafish","volume":"25","author":"Morikane","year":"2020","journal-title":"Molecules"},{"key":"2024050814452897700_bib106","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4939-6673-8_16","article-title":"The zebrafish as a model for human bacterial infections","volume-title":"Bacterial Pathogensis: Methods and Protocols","author":"Neely","year":"2017"},{"key":"2024050814452897700_bib107","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ydbio.2005.07.013","article-title":"Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis","volume":"286","author":"Ng","year":"2005","journal-title":"Dev Biol"},{"key":"2024050814452897700_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pathogens10040401","article-title":"A novel infection protocol in zebrafish embryo to assess Pseudomonas aeruginosa virulence and validate efficacy of a quorum sensing inhibitor in vivo","volume":"10","author":"Nogaret","year":"2021","journal-title":"Pathogens"},{"key":"2024050814452897700_bib109","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1074\/jbc.M110.198879","article-title":"Clemastine potentiates the human P2\u00d77 receptor by sensitizing it to lower ATP concentrations","volume":"286","author":"Norenberg","year":"2011","journal-title":"J Biol Chem"},{"key":"2024050814452897700_bib111","volume-title":"Tackling drug-resistant infections globally: final report and recommendations","author":"O'Neil","year":"2016"},{"key":"2024050814452897700_bib110","first-page":"1","article-title":"Zebrafish is a powerful tool for precision medicine approaches to neurological disorders","volume":"15","author":"Ochenkowska","year":"2022","journal-title":"Mol Neurosci"},{"key":"2024050814452897700_bib112","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/AAC.03588-14","article-title":"Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen","volume":"59","author":"Ordas","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050814452897700_bib114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof8030264","article-title":"Novel insights into Aspergillus fumigatus pathogenesis and host response from state-of-the-art imaging of host-pathogen interactions during infection","volume":"8","author":"Ortiz","year":"2022","journal-title":"J Fungi"},{"key":"2024050814452897700_bib115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1002944","article-title":"Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish","volume":"8","author":"Parikka","year":"2012","journal-title":"PLoS Pathog"},{"key":"2024050814452897700_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25194474","article-title":"Drug administration routes impact the metabolism of a synthetic cannabinoid in the zebrafish larvae model","volume":"25","author":"Park","year":"2020","journal-title":"Molecules"},{"key":"2024050814452897700_bib117","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.3390\/ijms241210076","article-title":"Optimization of mass spectrometry imaging for drug metabolism and distribution studies in the zebrafish larvae model: a case study with the opioid antagonist naloxone","volume":"24","author":"Park","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024050814452897700_bib118","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1128\/AAC.45.5.1337-1342.2001","article-title":"Synergy of histone-derived peptides of Coho salmon with lysozyme and flounder pleurocidin","volume":"45","author":"Patrzykat","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050814452897700_bib119","first-page":"611","article-title":"Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials","volume":"20","author":"Patton","year":"2021","journal-title":"Nat Rev"},{"key":"2024050814452897700_bib120","doi-asserted-by":"crossref","first-page":"15303","DOI":"10.1021\/jacs.2c06304","article-title":"Covalent proteomimetic inhibitor of the bacterial FtsQB divisome complex","volume":"144","author":"Paulussen","year":"2022","journal-title":"J Am Chem Soc"},{"key":"2024050814452897700_bib121","first-page":"1","article-title":"CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection","volume":"33","author":"Pendergast","year":"2023","journal-title":"Curr Biol"},{"key":"2024050814452897700_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1007247","article-title":"EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF","volume":"14","author":"Phan","year":"2018","journal-title":"PLoS Pathog"},{"key":"2024050814452897700_bib123","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-pathol-011811-132458","article-title":"Tuberculosis pathogenesis and immunity","volume":"7","author":"Philips","year":"2011","journal-title":"Ann Rev Pathol"},{"key":"2024050814452897700_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2021.745851","article-title":"Zebrafish embryo infection model to investigate Pseudomonas aeruginosa interaction with innate immunity and validate new therapeutics","volume":"11","author":"Pont","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2024050814452897700_bib125","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00204-016-1789-5","article-title":"Humanizing the zebrafish liver shifts drug Metabolic profiles and improves pharmacokinetics of CYP3A4 substrates","volume":"91","author":"Poon","year":"2017","journal-title":"Arch Toxicol"},{"key":"2024050814452897700_bib126","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.dci.2004.10.007","article-title":"Pathogenesis and inflammatory response to Edwardsiella tarda infection in zebrafish","volume":"29","author":"Pressley","year":"2005","journal-title":"Dev Compar Immunol"},{"key":"2024050814452897700_bib127","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/nm.3937","article-title":"The association between sterilizing activity and drug distribution into tuberculosis lesions","volume":"10","author":"Prideaux","year":"2015","journal-title":"Nat Med"},{"key":"2024050814452897700_bib128","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-1097(03)00446-4","article-title":"Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis","volume":"225","author":"Prouty","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"2024050814452897700_bib129","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.chom.2019.12.005","article-title":"Aryl hydrocarbon receptor modulation by tuberculosis drugs impairs host defense and treatment outcomes","volume":"27","author":"Puyskens","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2024050814452897700_bib130","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nri3211","article-title":"Revisiting the role of the granuloma in tuberculosis","volume":"12","author":"Ramakrishnan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"2024050814452897700_bib131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph14060594","article-title":"Zebrafish: an attractive model to study Staphylococcus aureus infection and its use as a drug discovery tool","volume":"14","author":"Rasheed","year":"2021","journal-title":"Pharmaceuticals"},{"key":"2024050814452897700_bib132","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"key":"2024050814452897700_bib133","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/B978-0-12-809405-1.00012-2","article-title":"Zebrafish as a model for developmental biology and toxicology","volume":"2","author":"Roper","year":"2018","journal-title":"Handbook Dev Neurotoxicol"},{"key":"2024050814452897700_bib134","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.3390\/ijms23126647","article-title":"Zebrafish larvae behavior models as a tool for drug screenings and pre-clinical trials: a review","volume":"23","author":"Rosa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024050814452897700_bib135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1517\/17425255.2.2.231","article-title":"Zebrafish assays for drug toxicity screening","volume":"2","author":"Rubinstein","year":"2006","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2024050814452897700_bib136","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mib.2012.11.007","article-title":"The evolutionary pressures that have molded Mycobacterium tuberculosis into an infectious adjuvant","volume":"16","author":"Russell","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"2024050814452897700_bib137","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tiv.2017.05.009","article-title":"In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds","volume":"42","author":"Saad","year":"2017","journal-title":"Toxicol in Vitro"},{"key":"2024050814452897700_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines8090329","article-title":"An overview of methods for cardiac rhythm detection in zebrafish","volume":"8","author":"Santoso","year":"2020","journal-title":"Biomedicines"},{"key":"2024050814452897700_bib139","first-page":"151","article-title":"A molecular toolbox for genetic manipulation of zebrafish","volume":"5","author":"Sassen","year":"2015","journal-title":"Adv Genomics Genet"},{"key":"2024050814452897700_bib140","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11356-008-0018-z","article-title":"The zebrafish embryo model in environmental risk assessment\u2013applications beyond acute toxicity testing","volume":"15","author":"Scholz","year":"2008","journal-title":"Environ Sci Pollut Res Int"},{"key":"2024050814452897700_bib141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics11020273","article-title":"Stapling of peptides potentiates the antibiotic treatment of Acinetobacter baumannii in vivo","volume":"11","author":"Schouten","year":"2022","journal-title":"Antibiotics"},{"key":"2024050814452897700_bib142","first-page":"1","article-title":"A novel ultra-stable, monomeric green fluorescent protein for direct volumetric imaging of whole organs using CLARITY","volume":"8","author":"Scott","year":"2018","journal-title":"Nat Sci Rep"},{"key":"2024050814452897700_bib143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.00373","article-title":"Immersion infection of germ-free zebrafish with Listeria monocytogenes induces transient expression of innate immune response genes","volume":"6","author":"Shan","year":"2015","journal-title":"Front Microbiol"},{"key":"2024050814452897700_bib144","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.2147\/IJN.S26547","article-title":"Mesoporous silica nanoparticles as a compound delivery system in zebrafish embryos","volume":"7","author":"Sharif","year":"2012","journal-title":"Int J Nanomed"},{"key":"2024050814452897700_bib145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1128\/CMR.00030-10","article-title":"Challenges of antibacterial discovery","volume":"24","author":"Silver","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"2024050814452897700_bib146","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/zeb.2014.0976","article-title":"Growth and maturation in the zebrafish, Danio rerio: a staging tool for teaching and research","volume":"11","author":"Singleman","year":"2014","journal-title":"Zebrafish"},{"key":"2024050814452897700_bib147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2020.112533","article-title":"Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"205","author":"Sovari","year":"2020","journal-title":"Eur J Med Chem"},{"key":"2024050814452897700_bib148","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ymeth.2013.06.002","article-title":"Robotic injection of zebrafish embryos for high-throughput screening in disease models","volume":"62","author":"Spaink","year":"2013","journal-title":"Methods"},{"key":"2024050814452897700_bib149","doi-asserted-by":"crossref","first-page":"11565","DOI":"10.1073\/pnas.1302114110","article-title":"Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32","volume":"110","author":"Stanley","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"2024050814452897700_bib150","doi-asserted-by":"crossref","first-page":"14913","DOI":"10.1021\/bi048725t","article-title":"Comparative studies on the structure and stability of fluorescent proteins EGFP, zFP506, mRFP1, \u201cdimer2\u201d, and DsRed1","volume":"43","author":"Stepanenko","year":"2004","journal-title":"Biochemistry"},{"key":"2024050814452897700_bib151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.01043","article-title":"Epicatechin gallate, a naturally occurring polyphenol, alters the course of infection with \u03b2-lactam-resistant Staphylococcus aureus in the zebrafish embryo","volume":"6","author":"Stevens","year":"2015","journal-title":"Front Microbiol"},{"key":"2024050814452897700_bib152","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/cvr\/cvab214","article-title":"Hooked on heart regeneration: the zebrafish guide to recovery","volume":"118","author":"Stewart","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2024050814452897700_bib153","first-page":"1","article-title":"Analysis tools to quantify dissemination of pathology in zebrafish larvae","volume":"20","author":"Stirling","year":"2020","journal-title":"Nat Sci Rep"},{"key":"2024050814452897700_bib154","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1242\/dmm.006676","article-title":"Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component","volume":"4","author":"Stoop","year":"2011","journal-title":"Dis Models Mech"},{"key":"2024050814452897700_bib155","volume-title":"The Paradigm Shift 2018-2022: Global Plan to End TB","author":"Stop TB Partnership","year":"2019"},{"key":"2024050814452897700_bib156","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.reprotox.2011.06.121","article-title":"Zebrafish embryos as an alternative to animal experiments\u2014a commentary on the definition of the onset of protected life stages in animal welfare regulations","volume":"33","author":"Strahle","year":"2011","journal-title":"Reprod Toxicol"},{"key":"2024050814452897700_bib157","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.it.2022.03.011","article-title":"Zebrafish: an underutilized tool for discovery in host-microbe interactions","volume":"43","author":"Stream","year":"2022","journal-title":"Trends Immunol"},{"key":"2024050814452897700_bib158","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.mcb.2016.10.005","article-title":"Infectious disease models in zebrafish","volume":"138","author":"Sullivan","year":"2017","journal-title":"Methods Cell Biol"},{"key":"2024050814452897700_bib159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1009965","article-title":"Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline","volume":"17","author":"Sullivan","year":"2021","journal-title":"PLoS Pathog"},{"key":"2024050814452897700_bib160","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1128\/IAI.00887-06","article-title":"Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity","volume":"74","author":"Swaim","year":"2006","journal-title":"Infect Immun"},{"key":"2024050814452897700_bib161","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.celrep.2012.06.008","article-title":"An in vivo platform for rapid high-throughput antitubercular drug discovery","volume":"2","author":"Takaki","year":"2012","journal-title":"Cell Rep"},{"key":"2024050814452897700_bib162","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nprot.2013.068","article-title":"Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish","volume":"8","author":"Takaki","year":"2013","journal-title":"Nat Protoc"},{"key":"2024050814452897700_bib163","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/jn\/131.7.2067","article-title":"Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate","volume":"131","author":"Terpstra","year":"2001","journal-title":"J Nutr"},{"key":"2024050814452897700_bib164","article-title":"Expression of the zebrafish genome during embryogenesis (NIH R01 RR15402)","author":"Thisse","year":"2001"},{"key":"2024050814452897700_bib167","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"2024050814452897700_bib166","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","article-title":"The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans","volume":"140","author":"Tobin","year":"2010","journal-title":"Cell"},{"key":"2024050814452897700_bib165","first-page":"1","article-title":"Host-directed therapies for tuberculosis","volume":"5","author":"Tobin","year":"2015","journal-title":"Cold Spring Harb Lab Press"},{"key":"2024050814452897700_bib168","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1089\/zeb.2012.0814","article-title":"Colonizing the embryonic zebrafish gut with anaerobic bacteria derived from the human gastrointestinal tract","volume":"10","author":"Toh","year":"2013","journal-title":"Zebrafish"},{"key":"2024050814452897700_bib196_350_162824","first-page":"1367938","article-title":"Identification of kinase modulators as host-directed therapeutics against intracellular methicillin-resistant Staphylococcus aureus","volume-title":"Front Cell Infect Microbiol","author":"van\u00a0den\u00a0Biggelaar","year":"2024"},{"key":"2024050814452897700_bib170","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1462-5822.2003.00303.x","article-title":"Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infections","volume":"5","author":"Van\u00a0der\u00a0Sar","year":"2003","journal-title":"Cell Microbiol"},{"key":"2024050814452897700_bib171","first-page":"451","article-title":"A star with stripes: zebrafish as an infection model","volume":"12","author":"Van\u00a0der\u00a0Sar","year":"2004","journal-title":"Trends Immunol"},{"key":"2024050814452897700_bib172","first-page":"1","article-title":"Mycobacteria employ two different mechanisms to cross the blood\u2013brain barrier","volume":"20","author":"Van\u00a0Leeuwen","year":"2018","journal-title":"Cell Microbiol"},{"key":"2024050814452897700_bib173","first-page":"1","article-title":"Animal models of tuberculosis: zebrafish","volume":"5","author":"Van\u00a0Leeuwen","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2024050814452897700_bib174","first-page":"1","article-title":"Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda","volume":"12","author":"Van\u00a0Soest","year":"2011","journal-title":"BMC Immunol"},{"key":"2024050814452897700_bib175","first-page":"1","article-title":"Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae","volume":"9","author":"Van\u00a0Wijk","year":"2019","journal-title":"Nat Sci Rep"},{"key":"2024050814452897700_bib176","first-page":"183","article-title":"Static Immersion and Injection Methods for Live Cell Imaging of Foodborne Pathogen Infections in Zebrafish Larvae","volume-title":"Foodborne bacterial pathogens","author":"Varas","year":"2018"},{"key":"2024050814452897700_bib177","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.antiviral.2016.12.013","article-title":"Modelling viral infections using zebrafish: innate immune response and antiviral research","volume":"139","author":"Varela","year":"2017","journal-title":"Antiviral Res"},{"key":"2024050814452897700_bib178","first-page":"1","article-title":"Establishment and optimization of a high throughput setup to study Staphylococcus epidermis and Mycobacterium marinum infection as a model for drug discovery","volume":"88","author":"Veneman","year":"2014","journal-title":"J Vis Exp"},{"key":"2024050814452897700_bib179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-14-255","article-title":"A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery","volume":"14","author":"Veneman","year":"2013","journal-title":"BMC Genomics"},{"key":"2024050814452897700_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19123976","article-title":"From mRNA Expression of drug disposition genes to in vivo assessment of CYP-mediated biotransformation during zebrafish embryonic and larval development","volume":"19","author":"Verbueken","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2024050814452897700_bib181","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/ftox.2021.629229","article-title":"Translating neurobehavioral toxicity across species from zebrafish to rats to humans: implications for risk assessment","volume":"3","author":"Vorhees","year":"2021","journal-title":"Front Toxicol"},{"key":"2024050814452897700_bib182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0138949","article-title":"The macrophage-specific promoter mfap4 allows live, long-term analysis of macrophage behavior during mycobacterial infection in zebrafish","volume":"10","author":"Walton","year":"2015","journal-title":"PLoS ONE"},{"key":"2024050814452897700_bib183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pbio.2001644","article-title":"High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance","volume":"15","author":"Wambaugh","year":"2017","journal-title":"PLoS Biol"},{"key":"2024050814452897700_bib184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0000862","article-title":"A fully automated robotic system for microinjection of zebrafish embryos","volume":"2","author":"Wang","year":"2007","journal-title":"PLoS ONE"},{"key":"2024050814452897700_bib185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2021.130036","article-title":"Enhanced antibacterial activity of eugenol-entrapped casein nanoparticles amended with lysozyme against Gram-positive pathogens","volume":"360","author":"Wang","year":"2021","journal-title":"Food Chem"},{"key":"2024050814452897700_bib186","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","article-title":"Transparent adult zebrafish as a tool for in vivo transplantation analysis","volume":"2","author":"White","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2024050814452897700_bib189","article-title":"Antibacterial agents in clinical and preclinical development: an overview and analysis","author":"WHO","year":"2020"},{"key":"2024050814452897700_bib187","article-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics","author":"WHO","year":"2017"},{"key":"2024050814452897700_bib188","article-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics","author":"WHO","year":"2017"},{"key":"2024050814452897700_bib190","first-page":"1","article-title":"Disulfiram is effective against drug-resistant Mycobacterium abscessus in a zebrafish embryo infection model","volume":"66","author":"Winters","year":"2022","journal-title":"Clin Ther"},{"key":"2024050814452897700_bib191","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mib.2016.05.006","article-title":"Cell wall hydrolases and antibiotics: exploiting synergy to create efficacious new antimicrobial treatments","volume":"33","author":"Wittekind","year":"2016","journal-title":"Curr Opin Microbiol"},{"key":"2024050814452897700_bib113","volume-title":"Global Action Plan on Antimicrobial Resistance","author":"World Health Organization","year":"2015"},{"key":"2024050814452897700_bib192","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1002\/adma.201202847","article-title":"Bacteria-responsive multifunctional nanogel for targeted antibiotic delivery","volume":"24","author":"Xiong","year":"2012","journal-title":"Adv Mater"},{"key":"2024050814452897700_bib193","first-page":"1","article-title":"A zebrafish larval model to assess virulence of porcine Streptococcus suis Strains","volume":"11","author":"Zaccaria","year":"2015","journal-title":"PLoS ONE"},{"key":"2024050814452897700_bib194","first-page":"1","article-title":"Antibiotic toxicity and absorption in zebrafish using liquid chromatography-tandem mass spectrometry","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"},{"key":"2024050814452897700_bib195","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.2147\/IJN.S168959","article-title":"Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae","volume":"13","author":"Zhang","year":"2018","journal-title":"Int J Nanomed"}],"container-title":["FEMS Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/femsre\/advance-article-pdf\/doi\/10.1093\/femsre\/fuae011\/57356759\/fuae011.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsre\/article-pdf\/48\/3\/fuae011\/57450515\/fuae011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsre\/article-pdf\/48\/3\/fuae011\/57450515\/fuae011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T10:48:54Z","timestamp":1715165334000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsre\/article\/doi\/10.1093\/femsre\/fuae011\/7659820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":195,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5,8]]}},"URL":"https:\/\/doi.org\/10.1093\/femsre\/fuae011","relation":{},"ISSN":["1574-6976"],"issn-type":[{"value":"1574-6976","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,4,29]]},"article-number":"fuae011"}}