{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:59:58Z","timestamp":1792403998804,"version":"4.4.0"},"reference-count":181,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":146,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006454","name":"FSVO","doi-asserted-by":"publisher","award":["4.20.01"],"award-info":[{"award-number":["4.20.01"]}],"id":[{"id":"10.13039\/501100006454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science","doi-asserted-by":"publisher","award":["225679"],"award-info":[{"award-number":["225679"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The disease burden from Legionella spp. infections has been increasing in many industrialized countries and, despite decades of scientific advances, ranks amongst the highest for waterborne diseases. We review here several key research areas from a multidisciplinary perspective and list critical research needs to address some of the challenges of Legionella spp. management in engineered environments. These include: (i) a consideration of Legionella species diversity and cooccurrence, beyond Legionella pneumophila only; (ii) an assessment of their environmental prevalence and clinical relevance, and how that may affect legislation, management, and intervention prioritization; (iii) a consideration of Legionella spp. sources, their definition and prioritization; (iv) the factors affecting Legionnaires\u2019 disease seasonality, how they link to sources, Legionella spp. proliferation and ecology, and how these may be affected by climate change; (v) the challenge of saving energy in buildings while controlling Legionella spp. with high water temperatures and chemical disinfection; and (vi) the ecological interactions of Legionella spp. with other microbes, and their potential as a biological control strategy. Ultimately, we call for increased interdisciplinary collaboration between multiple research domains, as well as transdisciplinary engagement and collaboration across government, industry, and science as the way toward controlling and reducing Legionella-derived infections.<\/jats:p>","DOI":"10.1093\/femsre\/fuaf022","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T11:34:39Z","timestamp":1748345679000},"source":"Crossref","is-referenced-by-count":19,"title":["Foresight 2035: a perspective on the next decade of research on the management of\n                    <i>Legionella<\/i>\n                    spp. in engineered aquatic environments"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-4917","authenticated-orcid":false,"given":"Frederik","family":"Hammes","sequence":"first","affiliation":[{"name":"Eawag, Swiss Federal Institute of Aquatic Science and Technology , 8600 D\u00fcbendorf ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Eawag, Swiss Federal Institute of Aquatic Science and Technology , 8600 D\u00fcbendorf ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-8216","authenticated-orcid":false,"given":"Alessio","family":"Cavallaro","sequence":"additional","affiliation":[{"name":"Eawag, Swiss Federal Institute of Aquatic Science and Technology , 8600 D\u00fcbendorf ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Eichelberg","sequence":"additional","affiliation":[{"name":"Eawag, Swiss Federal Institute of Aquatic Science and Technology , 8600 D\u00fcbendorf ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Barigelli","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental and Applied Microbiology , Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Bigler","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute , 4123 Allschwil ,","place":["Switzerland"]},{"name":"University of Basel , 4001 Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2721-7715","authenticated-orcid":false,"given":"Sebastien P","family":"Faucher","sequence":"additional","affiliation":[{"name":"McGill University Department of Natural Resource Sciences, , Sainte-Anne-de-Bellevue, QC H9X 3V9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans P","family":"F\u00fcchslin","sequence":"additional","affiliation":[{"name":"Zurich Cantonal Laboratory , 8032 Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Gaia","sequence":"additional","affiliation":[{"name":"National Reference Center for Legionella, Institute of Laboratory Medicine , Ente Ospedaliero Cantonale , 6500 Bellinzona ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gomez-Valero","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Biologie des Bact\u00e9ries Intracellulaires, CNRS UMR 6047 , 75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Grimard-Conea","sequence":"additional","affiliation":[{"name":"Polytechnique Montr\u00e9al Department of Civil, Geological and Mining Engineering, , 83T1J4 Montreal ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N","family":"Haas","sequence":"additional","affiliation":[{"name":"Drexel University Department of Civil, Architectural and Environmental Engineering, , PA 19104 Philadelphia ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry A","family":"Hamilton","sequence":"additional","affiliation":[{"name":"School of Sustainable Engineering and the Built Environment, Arizona State University , AZ 85281 Tempe ,","place":["United States"]},{"name":"The Biodesign Center for Environmental Health Engineering , 1001 S McAllister Ave , Tempe, AZ 8528,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah G","family":"Healy","sequence":"additional","affiliation":[{"name":"Harvard T.H. 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