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Major advances in nucleic acid-based therapeutics, particularly antisense technologies, could be one solution for developing precision antibiotics. The selectivity and specificity in the drug design of antibacterial antisense oligomers (ASOs)\u202fallows precise gene-specific silencing and ultimately enables targeting of currently undruggable gene products. Our goal here is to comprehensively review the advances in asobiotics (antisense oligomer biotics) leading to therapeutic success, including modifications in the nucleic acid backbone of ASOs, which have improved their properties and progresses in delivery. We will discuss utilization of ASOs against several pathogens, strategies to overcome resistance, and finally future scenarios and prospects for asobiotics as pathogen-specific therapy in the clinic.<\/jats:p>","DOI":"10.1093\/femsre\/fuaf059","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:15:07Z","timestamp":1765458907000},"source":"Crossref","is-referenced-by-count":7,"title":["Developing antisense oligomer biotics \u201casobiotics\u201d as precision antibacterials: designs, strategies, and considerations for future success"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-5947","authenticated-orcid":false,"given":"Dina A","family":"Moustafa","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Emory University School of Medicine Department of Pediatrics, , Atlanta, GA 30322 ,","place":["United States"]},{"name":"Emory+Children\u2019s Center for Cystic 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